Depression trials in Spain

In Spain 32 Also abroad 664

32 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 10 November 2026. Ask the study team whether a trial fits you.

Phase 3Taking people
A Study of Brenipatide in Adult Participants With Major Depressive Disorder
Where
Barcelona, Madrid, Oviedo, Salamanca, Zamora
Age
18 years to 75 years
People
1,000 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07412756 · EU 2025-522308-25-00
Phase 3Taking people
Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder
Where
Barcelona, Madrid, Sabadell, Zamora
Age
18 years to 65 years
People
470 worldwide
Run by
Intra-Cellular Therapies, Inc.
See details and how to joinNCT05850689 · EU 2023-503836-41-00
Phase 3Taking people
Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms
Where
Barcelona, Bilbao, Madrid, Oviedo, Torrevieja
Age
18 years to 74 years
People
752 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT06559306 · EU 2023-509070-36-00
Phase 3Taking people
A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder
Where
Barcelona, Esplugues de Llobregat, Madrid, Manresa, Oviedo, Pamplona, Sabadell, Santander
Age
12 years to 17 years
People
258 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT07227454 · EU 2024-518615-19-00
Phase 3Taking people
A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder
Where
Barcelona, Centelles, Madrid, Salamanca, Sant Boi de Llobregat, Sevilla, Zamora, Servicio de Salud Mental del Área IV CSM La Corredoría Oviedo
Age
18 years to 75 years
People
1,000 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07775300 · EU 2025-522310-24-00
Phase 3Taking people
Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
Where
Alcorcón, Barcelona
Age
18 years and over
People
850 worldwide
Run by
Neurocrine Biosciences
See details and how to joinNCT06966401 · EU 2024-519423-24-00
Phase 3Taking people
A Study to Evaluate the Maintenance Effect of Osavampator as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
Where
Alcorcón, Barcelona
Age
18 years and over
People
550 worldwide
Run by
Neurocrine Biosciences
See details and how to joinNCT07196501 · EU 2025-520541-72-00
No phaseTaking people
Evaluation of a Multi-Layered Digital Phenotyping, Digital Safety Plan, and Pharmacogenomic Intervention for Suicide Prevention in Adults With Depression
Where
Madrid
Age
18 years and over
People
525
Run by
Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
See details and how to joinNCT07885722
No phaseTaking people
Evaluating a Personalised Online Program With Human Support for Women With Depression and Its Impact on Mental Health and Biological Changes
Where
Barcelona
Age
18 years to 45 years
People
120
Run by
Francesc Colom, PsyD, PhD
See details and how to joinNCT07060690
No phaseTaking people
Ultra-brief Psychological Treatments for Emotional Symptoms and Disorders
Where
Córdoba
Age
18 years and over
People
184
Run by
Universidad de Córdoba
See details and how to joinNCT06909669
Phase 3Taking people
Comparison of esketamine with an antidepressant versus aripiprazole with an antidepressant, in the refractory major depression disorder in elderly patients
Where
Barcelona, Granollers, Palencia, Pamplona, Sabadell, Barcelona, Sant Boi De Llobregat, Sevilla
Age
18 years and over
People
220
Run by
Fundacion Publica Andaluza Para La Gestion De La Investigacion En Salud De Sevilla
See details and how to join2024-512672-34-00 · EU 2024-512672-34-00
No phaseTaking people
Physical Therapy for Depression Quality of Life (Pilot Study Protocol)
Where
Zaragoza
Age
18 years and over
People
40
Run by
Universidad San Jorge
See details and how to joinNCT06983405
No phaseTaking people
Mindfulness-Based Cognitive Therapy (MBCT) for the Prevention of Depression Relapse or Recurrence Using Videoconference
Where
Barcelona, Elche, Sant Boi de Llobregat, Zaragoza
Age
18 years and over
People
342
Run by
Fundació Sant Joan de Déu
See details and how to joinNCT06832605
No phaseTaking people
Cerebral and Anti-inflammatory Response Through Exercise - Mechanisms In Depressive Disorders
Where
Alcalá de Henares, Madrid, Majadahonda
Age
18 years to 65 years
People
124
Run by
Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
See details and how to joinNCT06450704
Phase 2Not yet taking people in Spain
Antidepressant effects of psilocybin without the psychedelic serotonin experience: A dimensional approach using functional neuroimaging.
Where
Barcelona
Age
18 years and over
People
60
Run by
Fundacio Institut De Recerca De L'Hospital De La Santa Creu I Sant Pau
See details and how to join2025-521690-14-00 · EU 2025-521690-14-00
No phaseTaking people
EEG Prediction and Clinical Efficacy of tDCS in Major Depression
Where
Valencia
Age
18 years and over
People
270
Run by
Ionclinics & Deionic SL
See details and how to joinNCT07611773
Phase 4Taking people
Clinical Study Evaluating Pharmacogenomics-informed Pharmacotherapy Versus Dosing as Usual in Psychiatric Disorders
Where
Barcelona
Age
16 years to 70 years
People
2,500 worldwide
Run by
Parnassia Groep
See details and how to joinNCT05656469 · EU 2023-509680-25-00
Phase 4Taking people
Study evaluating the efficacy and safety of daridorexant in patients with major depressive disorder and insomnia.
Where
Badalona, L'hospitalet De Llobregat, Sabadell
Age
18 years and over
People
134
Run by
Fundacio Institut D'Investigacio Biomedica De Bellvitge IDIBELL
See details and how to join2025-524794-16-00 · EU 2025-524794-16-00
No phaseTaking people
Home tDCS for the Treatment of Major Depression.
Where
L'Hospitalet de Llobregat, Mataró, Sabadell
Age
18 years to 65 years
People
198
Run by
Ionclinics & Deionic SL
See details and how to joinNCT07510880
Phase 4Not yet taking people in Spain
Efficacy and Safety of Daridorexant in Patients With Major Depressive Disorder and Insomnia
Where
Barcelona
Age
18 years to 99 years
People
134
Run by
Institut d'Investigació Biomèdica de Bellvitge
See details and how to joinNCT07555743
No phaseEnrolling by invitation
Prospective Observational Study of the Relationship Between Sociodemographic Factors, Blood-based Biomarkers and Psychiatric Symptoms in Neurodegenerative Diseases and Mental Disorders
Where
Barcelona
Age
18 years and over
People
1,310
Run by
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
See details and how to joinNCT07239843
No phaseTaking people
Virtual Reality-Based Mindfulness as an Adjunct to Treatment as Usual in Treatment-Resistant Depression
Where
Barcelona
Age
18 years to 74 years
People
30
Run by
Hospital Universitari Vall d'Hebron Research Institute
See details and how to joinNCT07422519
No phaseEnrolling by invitation
Retrospective Observational Study of Blood-based Biomarkers in the Diagnosis and Monitoring of Patients With a Neurodegenerative Disease or Mental Disorder
Where
Barcelona
Age
18 years and over
People
1,799
Run by
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
See details and how to joinNCT07314190
No phaseEnrolling by invitation
Clinical Impact of an Anti-Inflammatory Diet in Anxiety and Depression With AI
Where
Zaragoza
Age
18 years and over
People
60
Run by
Universidad de Zaragoza
See details and how to joinNCT07398040
No phaseEnrolling by invitation
The Effect of Digital Markers in the Self-management of Depressive Symptoms
Where
Barcelona
Age
18 years and over
People
660 worldwide
Run by
Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
See details and how to joinNCT06919133