Taking people in United StatesPhase 3

Less invasive surgery compared with standard care for older adults with early melanoma

Tests cutting out melanoma alone, without lymph node removal, in adults aged 75 or older.

Plain-language title generated from the registry record
Registry title: Comparing the Effectiveness of Less Invasive Procedures With the Current Standard of Care for the Treatment of Older Adults With Early-Stage Melanoma

Key facts

Where: Albuquerque, Anaconda, Arroyo Grande, Atlanta, Aurora, Avon, Bardstown, Baton Rouge, Battle Creek, Beachwood, Bemidji, Berlin Corners, Billings, Birmingham, Bismarck, Bozeman, Bridgeport, Buffalo, Burlington, Burr Ridge, Carmichael, Cary, Chadds Ford, Charleston, Charlottesville, Cheyenne, Chicago, Cincinnati, Cleveland, Cody, Coeur d'Alene, Colorado Springs, Columbus, Corbin, Daphne, Durango, Durham, East Norriton, Elk Grove, Elkton, Erie, Evanston, Fairbanks, Fairhope, Fargo, Glens Falls, Glenview, Grand Island, Grand Rapids, Great Falls, Hackensack, Hackettstown, Havre, Helena, Highland Park, Homer Glen, Irvine, Kalamazoo, Kalispell, Kansas City, Kearney, La Jolla, Lake Forest, Lake Mary, Lakeland, Lakewood, Lee's Summit, Lewes, Lexington, Loma Linda, London, Long Branch, Longmont, Los Angeles, Marshfield, Martinsburg, Maywood, Melrose Park, Menomonee Falls, Merced, Millville, Milwaukee, Mineola, Missoula, Mobile, Morgantown, Morristown, Mount Sterling, Muskegon, Nashville, New Berlin, New Brunswick, New York, Newark, Newton, Niles, Norton Shores, Oak Creek, Ocoee, Oklahoma City, Omaha, Orange, Orland Park, Orlando, Overland Park, Paramus, Parkersburg, Patchogue, Philadelphia, Phoenix, Pittsburgh, Pompton, Post Falls, Princeton, Pueblo, Raleigh, Reed City, Rehoboth Beach, Reno, Richmond, Rocklin, Sacramento, Saint Joseph, San Luis Obispo, Sandpoint, Santa Maria, Saraland, Seattle, Silverdale, Stockton, Stony Brook, Summit, The Bronx, Thief River Falls, Toms River, Traverse City, West Bend, Westminster, Weston, Westwood, Willow Grove, Wilmington, Woodland, and Wyoming, United StatesSee the 181 sites
Phase: Phase 3

Where in United States

Lovelace Women's HospitalAlbuquerque, United StatesTaking people
University of New Mexico Cancer CenterAlbuquerque, United StatesTaking people
Community Hospital of AnacondaAnaconda, United StatesTaking people
Mission Hope Medical Oncology - Arroyo GrandeArroyo Grande, United StatesTaking people
Emory Saint Joseph's HospitalAtlanta, United StatesTaking people
Emory University Hospital/Winship Cancer InstituteAtlanta, United StatesTaking people
UCHealth University of Colorado HospitalAurora, United StatesTaking people
UH Seidman Cancer Center at UH Avon Health CenterAvon, United StatesTaking people
CommonSpirit Saint Joseph Hospital - BardstownBardstown, United StatesTaking people
LSU Health Baton Rouge-North ClinicBaton Rouge, United StatesTaking people
Our Lady of the Lake Physician GroupBaton Rouge, United StatesTaking people
Bronson Battle CreekBattle Creek, United StatesTaking people
UHHS-Chagrin Highlands Medical CenterBeachwood, United StatesTaking people
Sanford Joe Lueken Cancer CenterBemidji, United StatesTaking people
Central Vermont Medical Center/National Life Cancer TreatmentBerlin Corners, United StatesTaking people
Billings Clinic Cancer CenterBillings, United StatesTaking people
University of Alabama at Birmingham Cancer CenterBirmingham, United StatesTaking people
Sanford Bismarck Medical CenterBismarck, United StatesTaking people
Bozeman Health Deaconess HospitalBozeman, United StatesTaking people
United Hospital CenterBridgeport, United StatesTaking people
Roswell Park Cancer InstituteBuffalo, United StatesTaking people
University of Vermont and State Agricultural CollegeBurlington, United StatesTaking people
University of Vermont Medical CenterBurlington, United StatesTaking people
Loyola Center for Health at Burr RidgeBurr Ridge, United StatesTaking people
Mercy Cancer Center - CarmichaelCarmichael, United StatesTaking people
Mercy San Juan Medical CenterCarmichael, United StatesTaking people
Duke Cancer Center CaryCary, United StatesTaking people
Christiana Care Health System-Concord Health CenterChadds Ford, United StatesTaking people
Medical University of South CarolinaCharleston, United StatesTaking people
University of Virginia Cancer CenterCharlottesville, United StatesTaking people
Memorial Hospital of Laramie CountyCheyenne, United StatesTaking people
Northwestern UniversityChicago, United StatesTaking people
Swedish Covenant HospitalChicago, United StatesTaking people
Bethesda North HospitalCincinnati, United StatesTaking people
Good Samaritan Hospital - CincinnatiCincinnati, United StatesTaking people
TriHealth Cancer Institute-AndersonCincinnati, United StatesTaking people
TriHealth Cancer Institute-WestsideCincinnati, United StatesTaking people
Case Western Reserve UniversityCleveland, United StatesTaking people
Billings Clinic-CodyCody, United StatesTaking people
Kootenai Health - Coeur d'AleneCoeur d'Alene, United StatesTaking people
Penrose-Saint Francis HealthcareColorado Springs, United StatesTaking people
Rocky Mountain Cancer Centers-PenroseColorado Springs, United StatesTaking people
Saint Francis Cancer CenterColorado Springs, United StatesTaking people
Ohio State University Comprehensive Cancer CenterColumbus, United StatesTaking people
Commonwealth Cancer Center-CorbinCorbin, United StatesTaking people
Gulf Health Hospitals Inc/Infirmary Cancer Care - MalbisDaphne, United StatesTaking people
CommonSpirit Cancer Center MercyDurango, United StatesTaking people
Mercy Medical CenterDurango, United StatesTaking people
Duke University Medical CenterDurham, United StatesTaking people
Fox Chase Cancer Center - East Norriton Hospital Outpatient CenterEast Norriton, United StatesTaking people
Mercy Cancer Center - Elk GroveElk Grove, United StatesTaking people
Christiana Care - Union HospitalElkton, United StatesTaking people
UPMC Hillman Cancer Center ErieErie, United StatesTaking people
NorthShore University HealthSystem-Evanston HospitalEvanston, United StatesTaking people
Fairbanks Memorial HospitalFairbanks, United StatesTaking people
Thomas HospitalFairhope, United StatesTaking people
Sanford Broadway Medical CenterFargo, United StatesTaking people
Sanford Medical Center FargoFargo, United StatesTaking people
Sanford Roger Maris Cancer CenterFargo, United StatesTaking people
Sanford South University Medical CenterFargo, United StatesTaking people
Southpointe-Sanford Medical Center FargoFargo, United StatesTaking people
Glens Falls HospitalGlens Falls, United StatesTaking people
NorthShore University HealthSystem-Glenbrook HospitalGlenview, United StatesTaking people
CHI Health Saint FrancisGrand Island, United StatesTaking people
Corewell Health Grand Rapids Hospitals - Butterworth HospitalGrand Rapids, United StatesTaking people
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's HospitalGrand Rapids, United StatesTaking people
Trinity Health Grand Rapids HospitalGrand Rapids, United StatesNo longer taking part
Benefis Sletten Cancer InstituteGreat Falls, United StatesTaking people
Great Falls ClinicGreat Falls, United StatesTaking people
Hackensack University Medical CenterHackensack, United StatesTaking people
Hackettstown Medical CenterHackettstown, United StatesTaking people
Hi-Line Sletten Cancer CenterHavre, United StatesTaking people
Benefis Helena Specialty CenterHelena, United StatesTaking people
NorthShore University HealthSystem-Highland Park HospitalHighland Park, United StatesTaking people
Loyola Medicine Homer GlenHomer Glen, United StatesTaking people
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory CareIrvine, United StatesTaking people
Bronson Methodist HospitalKalamazoo, United StatesTaking people
West Michigan Cancer CenterKalamazoo, United StatesTaking people
Beacon KalamazooKalamazoo, United StatesNo longer taking part
Beacon Kalamazoo Cancer CenterKalamazoo, United StatesNo longer taking part
Logan Health Medical CenterKalispell, United StatesTaking people
University of Kansas Cancer CenterKansas City, United StatesTaking people
University of Kansas Cancer Center - BriarcliffKansas City, United StatesTaking people
University of Kansas Cancer Center - NorthKansas City, United StatesTaking people
CHI Health Good SamaritanKearney, United StatesTaking people
UC San Diego Moores Cancer CenterLa Jolla, United StatesTaking people
Northwestern Medicine Lake Forest HospitalLake Forest, United StatesTaking people
Orlando Health Cancer Institute - Lake MaryLake Mary, United StatesTaking people
Lakeland Regional Health Hollis Cancer CenterLakeland, United StatesTaking people
CommonSpirit Saint Anthony Hospital Cancer CenterLakewood, United StatesTaking people
University of Kansas Cancer Center - Lee's SummitLee's Summit, United StatesTaking people
Beebe Medical CenterLewes, United StatesTaking people
CommonSpirit Saint Joseph Hospital - LexingtonLexington, United StatesTaking people
CommonSpirit Saint Joseph Medical Center - East LexingtonLexington, United StatesTaking people
Saint Joseph Radiation Oncology Resource CenterLexington, United StatesTaking people
University of Kentucky/Markey Cancer CenterLexington, United StatesTaking people
Veterans Affairs Loma Linda Healthcare SystemLoma Linda, United StatesTaking people
CommonSpirit Saint Joseph Hospital LondonLondon, United StatesTaking people
Monmouth Medical CenterLong Branch, United StatesTaking people
Longmont United HospitalLongmont, United StatesTaking people
Los Angeles General Medical CenterLos Angeles, United StatesTaking people
USC / Norris Comprehensive Cancer CenterLos Angeles, United StatesTaking people
Marshfield Medical Center-MarshfieldMarshfield, United StatesTaking people
WVUH-Berkely Medical CenterMartinsburg, United StatesTaking people
Loyola University Medical CenterMaywood, United StatesTaking people
Marjorie Weinberg Cancer Center at Loyola-GottliebMelrose Park, United StatesTaking people
Froedtert Menomonee Falls HospitalMenomonee Falls, United StatesTaking people
Mercy Cancer CenterMerced, United StatesTaking people
Beebe South Coastal Health CampusMillville, United StatesTaking people
Medical College of WisconsinMilwaukee, United StatesTaking people
NYU Langone Hospital - Long IslandMineola, United StatesTaking people
Community Medical CenterMissoula, United StatesTaking people
Mobile Infirmary Medical CenterMobile, United StatesTaking people
West Virginia University HealthcareMorgantown, United StatesTaking people
Morristown Medical CenterMorristown, United StatesTaking people
CommonSpirit Saint Joseph Hospital Mount SterlingMount Sterling, United StatesTaking people
Trinity Health Muskegon HospitalMuskegon, United StatesNo longer taking part
Vanderbilt University/Ingram Cancer CenterNashville, United StatesTaking people
Froedtert and MCW Moorland Reserve Health CenterNew Berlin, United StatesTaking people
Rutgers Cancer Institute of New JerseyNew Brunswick, United StatesTaking people
Laura and Isaac Perlmutter Cancer Center at NYU LangoneNew York, United StatesTaking people
Christiana Care Health System-Christiana HospitalNewark, United StatesTaking people
Helen F Graham Cancer CenterNewark, United StatesTaking people
Medical Oncology Hematology Consultants PANewark, United StatesTaking people
Newton Medical CenterNewton, United StatesTaking people
Corewell Health Lakeland Hospitals - Niles HospitalNiles, United StatesTaking people
Cancer and Hematology Centers of Western Michigan - Norton ShoresNorton Shores, United StatesNo longer taking part
Drexel Town Square Health CenterOak Creek, United StatesTaking people
Health CentralOcoee, United StatesTaking people
University of Oklahoma Health Sciences CenterOklahoma City, United StatesTaking people
Alegent Health Bergan Mercy Medical CenterOmaha, United StatesTaking people
Alegent Health Immanuel Medical CenterOmaha, United StatesTaking people
Alegent Health Lakeside HospitalOmaha, United StatesTaking people
UC Irvine Health- Chao Family Comprehensive Cancer CenterOrange, United StatesTaking people
Northwestern Medicine Orland ParkOrland Park, United StatesTaking people
Orlando Health Cancer InstituteOrlando, United StatesTaking people
University of Kansas Cancer Center-Overland ParkOverland Park, United StatesTaking people
University of Kansas Hospital-Indian Creek CampusOverland Park, United StatesTaking people
John Theurer Cancer Center at From RoadParamus, United StatesTaking people
Camden Clark Medical CenterParkersburg, United StatesTaking people
NYU Langone Hospital - SuffolkPatchogue, United StatesTaking people
Fox Chase Cancer CenterPhiladelphia, United StatesTaking people
Thomas Jefferson University HospitalPhiladelphia, United StatesTaking people
Cancer Center at Saint Joseph'sPhoenix, United StatesTaking people
UPMC Hillman Cancer CenterPittsburgh, United StatesTaking people
Chilton Medical CenterPompton, United StatesTaking people
Kootenai Clinic Cancer Services - Post FallsPost Falls, United StatesTaking people
Princeton Community HospitalPrinceton, United StatesTaking people
Saint Mary Corwin Medical CenterPueblo, United StatesTaking people
Duke Cancer Center RaleighRaleigh, United StatesTaking people
Corewell Health Reed City HospitalReed City, United StatesTaking people
Beebe Health CampusRehoboth Beach, United StatesTaking people
Renown Regional Medical CenterReno, United StatesTaking people
VCU Massey Cancer Center at Stony PointRichmond, United StatesTaking people
VCU Massey Comprehensive Cancer CenterRichmond, United StatesTaking people
Mercy Cancer Center - RocklinRocklin, United StatesTaking people
Mercy Cancer Center - SacramentoSacramento, United StatesTaking people
Corewell Health Lakeland Hospitals - Marie Yeager Cancer CenterSaint Joseph, United StatesTaking people
Corewell Health Lakeland Hospitals - Saint Joseph HospitalSaint Joseph, United StatesTaking people
Pacific Central Coast Health Center-San Luis ObispoSan Luis Obispo, United StatesTaking people
Kootenai Clinic Cancer Services - SandpointSandpoint, United StatesTaking people
Mission Hope Medical Oncology - Santa MariaSanta Maria, United StatesTaking people
Gulf Health Hospitals Inc/Infirmary Cancer Care - SaralandSaraland, United StatesTaking people
Fred Hutchinson Cancer CenterSeattle, United StatesTaking people
University of Washington Medical Center - MontlakeSeattle, United StatesTaking people
Saint Joseph Medical Center Hematology and Oncology - SilverdaleSilverdale, United StatesTaking people
Saint Joseph's Medical CenterStockton, United StatesTaking people
Stony Brook University Medical CenterStony Brook, United StatesTaking people
Overlook HospitalSummit, United StatesTaking people
Montefiore Medical Center-Einstein CampusThe Bronx, United StatesTaking people
Sanford Thief River Falls Medical CenterThief River Falls, United StatesTaking people
Community Medical CenterToms River, United StatesTaking people
Munson Medical CenterTraverse City, United StatesTaking people
Froedtert West Bend Hospital/Kraemer Cancer CenterWest Bend, United StatesTaking people
Saint Anthony North HospitalWestminster, United StatesTaking people
Marshfield Medical Center - WestonWeston, United StatesTaking people
University of Kansas Hospital-Westwood Cancer CenterWestwood, United StatesTaking people
Asplundh Cancer PavilionWillow Grove, United StatesTaking people
Christiana Care Health System-Wilmington HospitalWilmington, United StatesTaking people
Woodland Memorial HospitalWoodland, United StatesTaking people
University of Michigan Health - WestWyoming, United StatesTaking people

Questions to ask the study team

How often do I need to come in, and for how long each time?
Are travel costs paid?
Can I keep my own doctor?
What happens if I want to stop?

Print a page for my doctor

Trial details

Who runs it: ECOG-ACRIN Cancer Research Group
Trial code: NCT07068074
Record updated: 24 September 2026
Original description: This phase III trial compares the effect of wide local excision (WLE) alone to usual care with WLE plus sentinel lymph node (SLN) biopsy for the treatment of older adults with early-stage melanoma. A WLE is a surgical procedure performed to cut out an abnormal lesion and some surrounding normal tissue. This is sometimes followed by a SLN biopsy, in which lymph nodes that tumor cells could spread to are removed as well. Using WLE alone may be just as effective as usual care in treating older adults with early-stage melanoma.Read full original descriptionShow less
A Randomized Phase III Study of Management of Treatment Naive Primary Melanoma in Elderly Patients
This phase III trial compares the effect of wide local excision (WLE) alone to usual care with WLE plus sentinel lymph node (SLN) biopsy for the treatment of older adults with early-stage melanoma. A WLE is a surgical procedure performed to cut out an abnormal lesion and some surrounding normal tissue. This is sometimes followed by a SLN biopsy, in which lymph nodes that tumor cells could spread to are removed as well. Using WLE alone may be just as effective as usual care in treating older adults with early-stage melanoma.
Inclusion: Patient must be ≥ 75 years of age; Patient must have Eastern Cooperative Oncology Group (ECOG) performance status of 0-2; Patient must have the ability to understand and the willingness to sign a written informed consent document. Patients with impaired decision-making capacity (IDMC) who have a legally authorized representative (LAR) or caregiver and/or family member available will also be considered eligible; Patient must have newly diagnosed primary cutaneous melanoma with wide local excision (WLE) and sentinel lymph node (SLN) biopsy indicated per the treating physician, pending definitive surgical management; NOTE: For WLE and SLN to be indicated, the patient must have either:; Pathologic features that include ≧ Breslow 0.8 mm OR Breslow < 0.8 mm determined at initial biopsy, with a positive margin, ulceration, lymphovascular invasion, perineural invasion or > 1 mitosis/mm\^2; OR; Risk of SLN metastasis of at least 5%, as calculated using the Melanoma Institute of Australia (MIA) Sentinel Node Metastasis Prediction Tool; Patient must be eligible for WLE and SLN biopsy. Patients for whom SLN biopsy would be contraindicated, difficult to perform (i.e., after prior surgery in the draining basin) or impossible (i.e., after prior lymphadenectomy for another cause) are not eligible; Patient must be eligible for surgery and not have uncontrolled medical condition that in the opinion of the medical or surgical oncologist precludes surgical management; Patient must not have an active infection that precludes enrollment to this study in opinion of treating investigator; Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months of randomization are eligible for this trial; Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial; Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association functional classification. To be eligible for this trial, patients should be class 2B or better; Patient must be English speaking to be eligible for this study in order to complete the patient-reported outcomes (PROs); NOTE: Sites cannot translate the associated quality of life (QOL) forms.
ClinicalTrials.gov NCT07068074