Probiotic Tested for Thinking Skills and Blood Sugar in Young Adults With Excess Weight
Tests a Lab4P probiotic against placebo in young adults with overweight or obesity.
Plain-language title generated from the registry record
Registry title: Probiotics, Cognition and Metabolic Health in Young Adults With Overweight or Obesity
Key facts
- Where
- Leeds, United KingdomSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 40 years old?
Source: NCT07073781, who can take part
Where in United Kingdom
- Leeds Beckett UniversityLeeds, United KingdomTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Leeds Beckett University
- Trial code
- NCT07073781
- Record updated
- 9 November 2026
- Original description
This 12-week, double-blind, placebo-controlled trial will examine whether daily supplementation with the Lab4P probiotic can improve cognitive performance and metabolic health in overweight and obese adults aged 18 to 40. Seventy participants will be randomly assigned to receive either Lab4P or a placebo. The study will assess changes in memory, executive function, and processing speed, along with blood glucose control, cardiovascular function, cholesterol levels, body composition, and markers of inflammation. The study will also analyse changes in the gut microbiome and evaluate the safety and tolerability of the probiotic.Read full original descriptionShow less
A Double-Blind, Placebo-Controlled Exploratory Trial Of Daily Lab4P Probiotic Supplementation For Cognitive Performance And Metabolic Regulation In Young Adults With Overweight Or Obesity
This 12-week, double-blind, placebo-controlled trial will examine whether daily supplementation with the Lab4P probiotic can improve cognitive performance and metabolic health in overweight and obese adults aged 18 to 40. Seventy participants will be randomly assigned to receive either Lab4P or a placebo. The study will assess changes in memory, executive function, and processing speed, along with blood glucose control, cardiovascular function, cholesterol levels, body composition, and markers of inflammation. The study will also analyse changes in the gut microbiome and evaluate the safety and tolerability of the probiotic.
Inclusion: Self-reported normal sleep patterns, with no history of diagnosed sleep disorders; Willing and able to comply with study procedures, including fasting and oral glucose tolerance testing (OGTT); Non-smoker at screening, with no regular tobacco use in the preceding six months; English proficiency equivalent to that of a native speaker.
Exclusion: Major surgery, significant trauma, systemic infection, or myocardial infarction within six weeks before screening; Night shift work within 30 days before screening or planned during the study. Pregnancy, breastfeeding, or plans to become pregnant during the study. Known allergy or hypersensitivity to any component of the investigational product or placebo; History of kidney disease, liver disease, low or high blood pressure, or heart disease; History of conditions that may affect food metabolism, including food allergies or gastrointestinal diseases such as irritable bowel syndrome or peptic ulcers; History of psychiatric illness, including anxiety or depression. Current use of prescription or over-the-counter medications, excluding hormonal contraception; Current or recent use, within four weeks, of medications affecting glucose metabolism or agents that may alter gut microbiota composition or probiotic efficacy, as defined in Section 8.6.