Sickle cell trait and bone, muscle and frailty after menopause

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for women of African descent, aged 50 or older, who have not had a period for at least 12 months. It compares women with and without sickle cell trait.

Age

50 years or older

Sex

Women only

Biomarker or test result

Women do not need to know if they have sickle cell trait; it is tested in the study.

Main reasons for not taking part

• Taking medicines that affect bone health, such as glucocorticoids, hormonal therapy, cancer or chemotherapy medicines, anti-resorptive medicines or anabolic therapies
• A known metabolic bone disorder, such as uncontrolled thyroid disease, hyperparathyroidism or Vitamin D deficiency
• Taking an investigational drug
• Documented sickle cell disease

The registry criteria, word for word

What the trial wants to find out

This is a cross-sectional, clinical research study comparing postmenopausal women of African Descent (AD) with different hemoglobin genotypes: normal and sickle cell trait (SCT). This research study has two purposes. The first purpose is to determine whether having SCT is a risk factor for the development of bone thinning in older women. The second purpose is to investigate whether women with SCT have reduced muscle function and increased frailty compared to women without SCT. The investigators estimate enrolling 50 female volunteers who are at least 50 years old and have not had a menstrual period for at least 12 consecutive months. Volunteers need not know whether they have SCT as this will be evaluated as part of the study.

The 2 groups in the trial

• Healthy volunteers without SCT

  Healthy women of African descent at least 50 years old without sickle cell trait and who have not had a menstrual period for at least 12 consecutive months.

• Healthy volunteers with SCT

  Healthy women of African descent at least 50 years old with sickle cell trait and who have not had a menstrual period for at least 12 consecutive months.