NCT07086989Recruiting
Cardiovascular Risk in Children With Chronic Conditions Study
Source: ClinicalTrials.gov · Last updated 8 Aug 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Children living with chronic health conditions face a higher risk of developing cardiovascular diseases than their peers, largely due to the accelerated aging of the heart and blood vessels. Although experts recognize this elevated risk and recommend close monitoring and early intervention, the underlying mechanisms driving this phenomenon remain poorly understood. At present, no effective interventions specifically target its root causes. Recent research shows that both large blood vessels (such as the carotid artery) and small vessels (such as those in the retina) can display early signs of damage decades before clinically apparent heart or vascular disease emerges. This accelerated vascular aging can result from multiple factors - including disease-related processes such as persistent inflammation and metabolic disturbances, treatment-related effects such as chemotherapy or long-term steroid use, and lifestyle changes associated with chronic illness, such as reduced physical activity and altered eating habits. However, it is still unclear how these factors influence the development and progression of vascular changes in children as they grow. Importantly, these changes can be monitored through non-invasive methods, offering a unique opportunity to study at-risk patients many years before overt cardiovascular disease develops. Identifying these early changes may enable us to detect and track individuals at heightened risk well in advance of clinical disease. This study aims to deepen our understanding of the causes of increased cardiovascular risk in children with chronic conditions and to lay the groundwork for earlier, more targeted prevention strategies.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 300 (estimated)
- First submitted
- 17 Jul 2025
- Start date
- 1 Apr 2025
- Primary completion date
- 31 Jan 2029
- Lead sponsor
- Semmelweis University
- Diseases
- Chronic kidney disease, Obesity, Familial hypercholesterolaemia, Pulmonary arterial hypertension, HIV, Fatty liver disease (MASLD/MASH), High blood pressure, Type 1 diabetes, Childhood cancers, Type 2 diabetes
- NCT number
- NCT07086989
What you commit to
- Study type: Observational
- Planned participants: 300
- From 1 Apr 2025 to the primary completion date, 31 Jan 2029
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Ongoing intravenous chemotherapy;
Other illness
- Decompensated heart failure;
- Infectious diseases posing a public health risk; or
- History of regular alcohol or drug use.
Other
- Severe intellectual and developmental disability;
- Severe primary immunodeficiency;
Who the study is looking for
- Individuals aged between 6 and 25 years;
- Diagnosed with a chronic childhood condition/disease associated with an increased risk of early cardiovascular disease;
- Provided informed consent (if over 18 years old) or had informed consent provided by their legal guardian (if under 18 years old) following appropriate information about the study.
- Chronic childhood conditions/diseases associated with increased risk of early cardiovascular disease are defined according to the 2019 American Heart Association recommendations (https://doi.org/10.1161/CIR.0000000000000618), as well as other conditions/diseases for which at least two large-scale epidemiological studies have demonstrated an increased risk of cardiovascular disease.
Age in the registry: 6 years to 25 years · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Semmelweis University, Department of Surgery, Transplantation and Gastroenterology Coordinator of this site? Confirm its status | Budapest | Hungary | Not yet recruiting |
| Semmelweis University, Institute of Preventive Medicine and Public Health Coordinator of this site? Confirm its status | Budapest | Hungary | Active, not recruiting |
| Semmelweis University, Pediatric Center Coordinator of this site? Confirm its status | Budapest | Hungary | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.