Heart and Blood Vessel Health in Children With Long-Term Conditions
Observes early blood vessel changes in children with chronic conditions like diabetes and kidney disease.
Plain-language title generated from the registry record
Registry title: Cardiovascular Risk in Children With Chronic Conditions Study
Key facts
- Where
- Budapest, HungarySee the 3 sites
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for children and young people with a long-term health condition that raises the risk of early heart and blood vessel disease.
- Age
- 6 to 25 years
- Sex
- All sexes can join.
- Disease stage
- A long-term childhood condition linked to a higher risk of early cardiovascular disease, as defined by the 2019 American Heart Association recommendations or by at least two large epidemiological studies.
- Earlier treatment
- Not stated. Ongoing intravenous chemotherapy is an exclusion.
Main reasons for not taking part
- Severe intellectual and developmental disability
- Decompensated heart failure
- Severe primary immunodeficiency
- Ongoing intravenous chemotherapy
- History of regular alcohol or drug use
Read by machine on 12 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 6 and 25 years old?
Source: NCT07086989, who can take part
Where in Hungary
- Semmelweis University, Department of Surgery, Transplantation and GastroenterologyBudapest, HungaryContact: Tamas Kiss, MD, PhDNot yet recruiting
- Semmelweis University, Pediatric CenterBudapest, HungaryContact: Tamas Kiss, MD, PhDTaking people
- Semmelweis University, Institute of Preventive Medicine and Public HealthBudapest, HungaryContact: Tamas Kiss, MD, PhDNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Semmelweis University
- Trial code
- NCT07086989
- Record updated
- 8 August 2025
- Original description
Children living with chronic health conditions face a higher risk of developing cardiovascular diseases than their peers, largely due to the accelerated aging of the heart and blood vessels. Although experts recognize this elevated risk and recommend close monitoring and early intervention, the underlying mechanisms driving this phenomenon remain poorly understood. At present, no effective interventions specifically target its root causes.Read full original descriptionShow less
Cardiovascular Risk in Children With Chronic Conditions Study
Children living with chronic health conditions face a higher risk of developing cardiovascular diseases than their peers, largely due to the accelerated aging of the heart and blood vessels. Although experts recognize this elevated risk and recommend close monitoring and early intervention, the underlying mechanisms driving this phenomenon remain poorly understood. At present, no effective interventions specifically target its root causes.
Recent research shows that both large blood vessels (such as the carotid artery) and small vessels (such as those in the retina) can display early signs of damage decades before clinically apparent heart or vascular disease emerges. This accelerated vascular aging can result from multiple factors - including disease-related processes such as persistent inflammation and metabolic disturbances, treatment-related effects such as chemotherapy or long-term steroid use, and lifestyle changes associated with chronic illness, such as reduced physical activity and altered eating habits. However, it is still unclear how these factors influence the development and progression of vascular changes in children as they grow. Importantly, these changes can be monitored through non-invasive methods, offering a unique opportunity to study at-risk patients many years before overt cardiovascular disease develops.
Identifying these early changes may enable us to detect and track individuals at heightened risk well in advance of clinical disease. This study aims to deepen our understanding of the causes of increased cardiovascular risk in children with chronic conditions and to lay the groundwork for earlier, more targeted prevention strategies.
Inclusion: Individuals aged between 6 and 25 years; Diagnosed with a chronic childhood condition/disease associated with an increased risk of early cardiovascular disease; Provided informed consent (if over 18 years old) or had informed consent provided by their legal guardian (if under 18 years old) following appropriate information about the study; Chronic childhood conditions/diseases associated with increased risk of early cardiovascular disease are defined according to the 2019 American Heart Association recommendations (https://doi.org/10.1161/CIR.0000000000000618), as well as other conditions/diseases for which at least two large-scale epidemiological studies have demonstrated an increased risk of cardiovascular disease.
Exclusion: Ongoing intravenous chemotherapy; Decompensated heart failure; Infectious diseases posing a public health risk; or; History of regular alcohol or drug use; Severe intellectual and developmental disability; Severe primary immunodeficiency.