Taking people in United StatesPhase 3

A Study of Dotinurad Versus Allopurinol in Participants With Gout

Key facts

Where: Ann Arbor, Atlanta, Birmingham, Bradenton, Brooklyn, Brownsburg, Charlotte, Charlottesville, Chicago, Coral Gables, Corpus Christi, Covina, Dallas, Dayton, Decatur, Denton, Denver, DeSoto, Dublin, Duncansville, Evansville, Fairfax, Flossmoor, Foley, Gilbert, Glendale, Great Falls, Greensboro, Hazelwood, Hendersonville, Hialeah, Houston, Hurst, Indianapolis, Jupiter, Katy, Lakeland, Lewisville, Louisville, Mason, Menifee, Mesa, Mesquite, Metairie, Miami, Miami Lakes, Morehead City, Naples, New Orleans, New York, Norco, North Charleston, North Las Vegas, Northridge, O'Fallon, Ogden, Oradell, Orange, Orlando, Overland Park, Oxon Hill, Pomona, Pompano Beach, Prairieville, Rapid City, Redmond, Rockville, Saint Clair Shores, San Antonio, San Bernardino, San Diego, San Leandro, San Marcos, Shelby, Southfield, Sparta, Spring Valley, Springfield, Sterling Heights, Sugar Land, Tampa, Thousand Oaks, Tomball, Town and Country, Troy, Tucson, Tujunga, Tulsa, Virginia Beach, Waltham, West Chester, West Long Branch, Wichita Falls, Willow Grove, and Winter Park, United StatesSee the 102 sites
Phase: Phase 3

Could this be for you?

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

Are you between 18 and 75 years old?

Source: NCT07089875, who can take part

Where in United States

Michigan Medicine - University of MichiganAnn Arbor, United StatesContact: Puja Khanna, MDTaking people
DelRicht Research - AtlantaAtlanta, United StatesContact: Clinical Trial LeadNo longer taking part
University of Alabama at BirminghamBirmingham, United StatesContact: Kenneth Saag, MDTaking people
Alabama Clinical TherapeuticsBirmingham, United StatesContact: Clinical Trial LeadNo longer taking part
Bradenton Research CenterBradenton, United StatesContact: Eric Folkens, MDTaking people
Ellipsis Research GroupBrooklyn, United StatesContact: Jorge Serje, MDTaking people
Investigators Research GroupBrownsburg, United StatesContact: Kenneth Maynard, MDTaking people
DelRicht ResearchCharlotte, United StatesContact: Olabisi Badmus, MDTaking people
Charlottesville Medical ResearchCharlottesville, United StatesContact: James Clark, MDTaking people
Chicago Clinical Research Institute, Inc. (CCRII)Chicago, United StatesContact: Manognya SamaTaking people
Flourish Chicago - Ravenswood (Great Lakes Clinical Trials)Chicago, United StatesContact: Manish Jain, MDTaking people
Herco Medical and Research Center, IncCoral Gables, United StatesContact: Eddy Capote, MDTaking people
Arthritis Care of TexasCorpus Christi, United StatesContact: Eric Chiang, MDTaking people
Medvin Clinical Research - CovinaCovina, United StatesContact: Samy Metyas, MDTaking people
Zenos Clinical ResearchDallas, United StatesContact: Durga Tanneru, MDTaking people
Hometown Urgent Care and Research - DaytonDayton, United StatesContact: Steve Choi, MDTaking people
Pediatrics & Adult Medicine/SKYCRNGDecatur, United StatesContact: Michele Sewell, MDTaking people
SKYCRNG - Rophe Adult and Pediatric MedicineDecatur, United StatesContact: Dwight Blake, MDTaking people
Lone Star Arthritis & Rheumatology Associates - DentonDenton, United StatesContact: Awilda (Michelle) Luciano, MDTaking people
Denver Arthritis Clinic - LowryDenver, United StatesContact: Christopher Antolini, MDTaking people
Epic Medical Research - DeSotoDeSoto, United StatesContact: Haresh Boghara, MDTaking people
West Coast ResearchDublin, United StatesContact: Tim DavisTaking people
Altoona Center For Clinical ResearchDuncansville, United StatesContact: Alan Kivitz, MDTaking people
MediSphere Medical Research Center, LLCEvansville, United StatesContact: Hubert Reyes, MDTaking people
Arthritis and Rheumatism AssociatesFairfax, United StatesContact: Daniel El-Bogdadi, MDTaking people
Healthcare Research Network - Tinley ParkFlossmoor, United StatesContact: Ronald Stumbris, MDTaking people
G&L ResearchFoley, United StatesContact: Nidal Morrar, MDTaking people
Arizona Arthritis & Rheumatology Associates (AARA) - GilbertGilbert, United StatesContact: Daniel Kreutz, MDTaking people
Arizona Arthritis & Rheumatology Associates (AARA) - GlendaleGlendale, United StatesContact: Nehad Soloman, MDTaking people
Boeson Research - Great FallsGreat Falls, United StatesContact: Richard Horng-Chy Lai, MDTaking people
Triad Clinical TrialsGreensboro, United StatesContact: Richard Montgomery, MDTaking people
Healthcare Research NetworkHazelwood, United StatesContact: Clinical Trial LeadNo longer taking part
DelRicht Research - HendersonvilleHendersonville, United StatesContact: Clinical Trial LeadNo longer taking part
Best Quality ResearchHialeah, United StatesContact: Gustavo Ledo-Sanchez, MDTaking people
New Generation of Medical ResearchHialeah, United StatesContact: Karelia Ruiz, MDTaking people
Pioneer Research SolutionsHouston, United StatesContact: Mozaffari ShahinTaking people
Prolato Clinical Research CenterHouston, United StatesContact: Michelle Eisenberg, MDTaking people
Epic Medical Research - HurstHurst, United StatesContact: Robert Strzinek, MDTaking people
Delricht Research - Better Life Direct Primary CareIndianapolis, United StatesContact: Clinical Trial LeadNo longer taking part
Health Awareness, IncJupiter, United StatesContact: Ronald Surowitz, MDTaking people
R&H Clinical Research - Westborough DriveKaty, United StatesContact: Maryam Khawari, MDTaking people
Clinical Research of Center FloridaLakeland, United StatesContact: Michael Gimness, MDTaking people
Alliance Clinical Lewisville (Epic Clinical Research)Lewisville, United StatesContact: Clinical Trial LeadNo longer taking part
DelRicht Research - Louisville (Derby City DPC)Louisville, United StatesContact: Michael Lovelace, MDTaking people
Delricht Research - Concierge Medicine Of CincinnatiMason, United StatesContact: Clinical Trial LeadNo longer taking part
Southland Arthritis and Osteoporosis Medical Center, IncMenifee, United StatesContact: Amal Mehta, MDTaking people
Arizona Arthritis & Rheumatology Associates (AARA) - MesaMesa, United StatesContact: Swati Bharadwaj, MDTaking people
Southwest Rheumatology ResearchMesquite, United StatesContact: Atul Singhal, MDTaking people
Tandem Clinical Research - Metairie ClinicMetairie, United StatesContact: Clinical Trial LeadNo longer taking part
Anchor Medical Research LLCMiami, United StatesContact: Juvenal Martinez, MDTaking people
Well Pharma Medical ResearchMiami, United StatesContact: Eddie Armas, MDTaking people
Panax Clinical ResearchMiami Lakes, United StatesContact: Robert G. Perry, MDTaking people
Carteret Medical Group LLCMorehead City, United StatesContact: Mary Lawrence, MDTaking people
UltraHealth, LLCNaples, United StatesContact: Carolina Otero, MDTaking people
DelRicht Research - LCMC Health Urgent Care - LakeviewNew Orleans, United StatesContact: Emily KrambeckTaking people
NYU Langone HealthNew York, United StatesContact: Michael Pillinger, MDTaking people
Infinity Clinical ResearchNorco, United StatesContact: Peter Mattar, MDTaking people
Coastal Carolina Research Center - MainNorth Charleston, United StatesContact: Rica Santiago, MDTaking people
Las Vegas Clinical TrialsNorth Las Vegas, United StatesContact: Alton Walters, MDTaking people
Amicis Research Center - BalboaNorthridge, United StatesContact: Pascal Dabel, MDTaking people
Gateway Clinical TrialsO'Fallon, United StatesContact: Christopher Anderson, MDTaking people
Ogden Clinic Canyon View/RIO Clinical TrialsOgden, United StatesContact: Stephen Bruce, MDTaking people
Curalta Clinical TrialsOradell, United StatesContact: Vincent Giacalone, MDTaking people
Cure Clinical ResearchOrange, United StatesContact: Ramprasad Dandillaya, MDTaking people
Omega Research DeBaryOrlando, United StatesContact: Kwabena Ayesu, MDTaking people
Delricht Research - Concierge And Direct Primary CareOverland Park, United StatesContact: Jonathan T. Jacobs, MDTaking people
MD Medical Research - Oxon HillOxon Hill, United StatesContact: Stephen Ong, MDTaking people
Dream Team Clinical ResearchPomona, United StatesContact: Clinical Trial LeadNo longer taking part
D & H Pompano Research CenterPompano Beach, United StatesContact: Mazyar Rouhani, MDTaking people
DelRicht Research - PrairievillePrairieville, United StatesContact: Clinical Trial LeadNo longer taking part
Health ConceptsRapid City, United StatesContact: Richard Beasley, MDTaking people
Eastside Research AssociatesRedmond, United StatesContact: Christopher Price, MDTaking people
DelRicht Research - Maryland (Matthew L. Mintz, MD, FACP)Rockville, United StatesContact: Clinical Trial LeadNo longer taking part
Clinical Research Institute of Michigan - St. Clair ShoresSaint Clair Shores, United StatesContact: Amar Majjhoo, MDTaking people
Discovery Clinical TrialsSan Antonio, United StatesContact: Abha Gyani, MDTaking people
ERG - Endeavor Clinical TrialsSan Antonio, United StatesContact: Nitendra Agarwal, MDTaking people
Velocity Clinical Research, San BernardinoSan Bernardino, United StatesContact: Judith Albay, MDTaking people
Acclaim Clinical Research, Inc.San Diego, United StatesContact: Julie Vu, MDTaking people
East Bay Rheumatology Medical GroupSan Leandro, United StatesContact: Suneet Grewal, MDTaking people
Epic Medical Research - San MarcosSan Marcos, United StatesContact: Maria De Jesus Salinas, MDTaking people
Shelby Clinical Research, LLC - North CarolinaShelby, United StatesContact: Christian Martin, MDTaking people
DM Clinical Research - DetroitSouthfield, United StatesContact: Clinical Trial LeadNo longer taking part
Premier Health ResearchSparta, United StatesContact: Haroon Sarwar, MDTaking people
BTC Network - Encompass Clinical ResearchSpring Valley, United StatesContact: Hanid Audish, MDTaking people
Delricht Research - Command Family MedicineSpringfield, United StatesContact: Clinical Trial LeadNo longer taking part
Revive Research Institute - Sterling HeightsSterling Heights, United StatesContact: Syed Ali Muttaqi Husain, MDTaking people
Siena Research NetworkSugar Land, United StatesContact: Mehjabin Parkar, MDTaking people
Clinical Research Trials of FloridaTampa, United StatesContact: Viviana FonsecaTaking people
Cohen Medical CentersThousand Oaks, United StatesContact: Shariar Cohen-Gadol, MDTaking people
DM Clinical Research - Tomball - Multiple SpecialtiesTomball, United StatesContact: Shaikh Ali, MDTaking people
DelRicht Research - Town and CountryTown and Country, United StatesContact: Amy E. Roberts, MDTaking people
Oakland Medical CenterTroy, United StatesContact: Jay Sandberg, MDTaking people
Del Sol Research Management - Tucson EastTucson, United StatesContact: Vicki Kalen, MDTaking people
Medvin Clinical Research - TujungaTujunga, United StatesContact: Clinical Trial LeadNo longer taking part
DelRicht Research - TulsaTulsa, United StatesContact: Clinical Trial LeadNo longer taking part
Gershon Pain SpecialistsVirginia Beach, United StatesContact: Steven Gershon, MDTaking people
MedVadis ResearchWaltham, United StatesContact: David DiBenedetto, MDTaking people
Suburban Research Associates - West Chester OfficeWest Chester, United StatesContact: Clinical Trial LeadNo longer taking part
Sahni Rheumatology & TherapyWest Long Branch, United StatesContact: Kiren Sahni, MDTaking people
Digestive Health Research of North TexasWichita Falls, United StatesContact: Vanya Wagler, MDTaking people
Rheumatic Disease AssociatesWillow Grove, United StatesContact: Elana Eisner, MDTaking people
Conquest Research-Winter ParkWinter Park, United StatesContact: Anand Patel, MDTaking people

Questions to ask the study team

How often do I need to come in, and for how long each time?
Are travel costs paid?
Can I keep my own doctor?
What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Trial details

Who runs it: Crystalys Therapeutics
Trial code: NCT07089875 EU 2024-520206-19-00
Record updated: 12 November 2026
Original description: The primary objective of this study is to evaluate the efficacy of dotinurad in lowering serum uric acid (sUA) at Week 24 compared with allopurinol in adult participants with hyperuricemia associated with gout.Read full original descriptionShow less
A Phase 3, Randomized, Double-Blind, Multicenter Study to Evaluate the Efficacy and Safety of Dotinurad Compared With Allopurinol in Adult Participants With Hyperuricemia Associated With Gout
The primary objective of this study is to evaluate the efficacy of dotinurad in lowering serum uric acid (sUA) at Week 24 compared with allopurinol in adult participants with hyperuricemia associated with gout.
Inclusion: Between 18 and 75 years of age (inclusive) at the time of signing informed consent; Diagnosis of gout based on 2015 American College of Rheumatology (ACR)-European Union League Against Rheumatism (EULAR) criteria for at least 1 year; Had at least 2 gout flares in the 12 months prior to Screening (reported by the participant or documented in the participant's medical records); Participant must be on a stable background allopurinol dose of ≥300 mg/day (200 mg/day for those with moderate renal impairment as documented in the participant's medical history) up to 600 mg/day for at least 3 months prior to Screening and remain on their dosing regimen until Day 1; sUA level ≥6.5 mg/dL at Screening Visit 1 (Day -35 Visit) and Screening Visit 2 (Day -7 Visit); Female participants of childbearing potential must have a negative serum pregnancy test at Screening Visit 1 (Day -35 Visit) and Screening Visit 2 (Day -7 Visit), a negative urine pregnancy test on Day 1, and must not be breastfeeding; Fertile male participants and female participants of childbearing potential must be willing to completely abstain from heterosexual sex or agree to use acceptable contraception from the time of signing informed consent through 30 days after the last dose of study drug.
Exclusion: History of or presence of kidney stones within 1 year prior to Screening; History of or presence of malignancy in the last 5 years other than treated cutaneous basal or squamous cell carcinoma; Hypersensitivity or intolerance to dotinurad or to both colchicine and nonsteroidal anti-inflammatory drugs; Known or suspected history of drug abuse, a positive drug test at Screening Visit 1, or a recent history of alcohol abuse; Known history of or positive results for human immunodeficiency virus, Hepatitis B Surface Antigen, or Hepatitis C antibodies during Screening; Current or historical evidence of any clinically significant disease or condition that, in the opinion of the Investigator, may compromise participant safety or study compliance or may confound interpretation of study results.
ClinicalTrials.gov NCT07089875 · EU CTIS 2024-520206-19-00