Gout trials in United States

In United States 14 Also abroad 51

14 trials · From ClinicalTrials.gov, checked 13 November 2026. Ask the study team whether a trial fits you.

Phase 3Taking people
A Study of Dotinurad Versus Allopurinol in Participants With Gout
Where
Ann Arbor, Atlanta, Birmingham, Bradenton, Brooklyn, Brownsburg, Charlotte, Charlottesville, Chicago, Coral Gables, Corpus Christi, Covina, Dallas, Dayton, Decatur, Denton, Denver, DeSoto, Dublin, Duncansville, Evansville, Fairfax, Flossmoor, Foley, Gilbert, Glendale, Great Falls, Greensboro, Hazelwood, Hendersonville, Hialeah, Houston, Hurst, Indianapolis, Jupiter, Katy, Lakeland, Lewisville, Louisville, Mason, Menifee, Mesa, Mesquite, Metairie, Miami, Miami Lakes, Morehead City, Naples, New Orleans, New York, Norco, North Charleston, North Las Vegas, Northridge, O'Fallon, Ogden, Oradell, Orange, Orlando, Overland Park, Oxon Hill, Pomona, Pompano Beach, Prairieville, Rapid City, Redmond, Rockville, Saint Clair Shores, San Antonio, San Bernardino, San Diego, San Leandro, San Marcos, Shelby, Southfield, Sparta, Springfield, Spring Valley, Sterling Heights, Sugar Land, Tampa, Thousand Oaks, Tomball, Town and Country, Troy, Tucson, Tujunga, Tulsa, Virginia Beach, Waltham, West Chester, West Long Branch, Wichita Falls, Willow Grove, Winter Park
Age
18 years to 75 years
People
500 worldwide
Run by
Crystalys Therapeutics
See details and how to joinNCT07089875 · EU 2024-520206-19-00
Phase 3Taking people
A Study of Dotinurad Versus Allopurinol in Tophaceous Gout
Where
Ann Arbor, Atlanta, Birmingham, Bradenton, Brooklyn, Charlotte, Charlottesville, Chicago, Coral Gables, Corpus Christi, Covina, Dallas, Dayton, Decatur, Denton, Denver, DeSoto, Dublin, Evansville, Fairfax, Foley, Gilbert, Glendale, Great Falls, Greensboro, Hendersonville, Hialeah, Houston, Hurst, Indianapolis, Jupiter, Katy, Lakeland, Lancaster, Lewisville, Louisville, Margate, Mason, Menifee, Mesa, Mesquite, Metairie, Miami, Miami Lakes, Naples, New Orleans, New York, Norco, North Charleston, North Las Vegas, Northridge, O'Fallon, Ogden, Oradell, Orange, Orlando, Overland Park, Oxon Hill, Pomona, Prairieville, Rapid City, Redmond, Rockville, Saint Clair Shores, San Antonio, San Bernardino, San Diego, San Leandro, San Marcos, Shelby, Southfield, Sparta, Springfield, Spring Valley, Sterling Heights, Sugar Land, Tampa, Thousand Oaks, Tomball, Town and Country, Troy, Tucson, Tujunga, Tulsa, Uniontown, Virginia Beach, Waltham, West Chester, West Long Branch, Wichita Falls, Willow Grove, Winter Park
Age
18 years to 75 years
People
250
Run by
Crystalys Therapeutics
See details and how to joinNCT07089888 · EU 2024-520207-84-00
Phase 4Taking people
Treat-to-Target Serum Urate Versus Treat-to-Avoid Symptoms in Gout
Where
Boston, Morgantown, New York, Santa Monica, South Birmingham
Age
18 years to 90 years
People
650
Run by
Massachusetts General Hospital
See details and how to joinNCT04875702
No phaseTaking people
Pharmacist-Led Treat-to-Target Urate Lowering Therapy in Patients With Gout
Where
Omaha, Philadelphia, Portland, Salt Lake City, Seattle
Age
18 years and over
People
310
Run by
VA Office of Research and Development
See details and how to joinNCT06887452
Phase 3Taking people
A Double-blind, Randomized Controlled Trial to Investigate the Efficacy, Safety, and Pharmacokinetics of Pegloticase Administration Via Subcutaneous and Intravenous Routes Both With Methotrexate in Participants With Uncontrolled Gout
Where
Albuquerque, Anaheim, Anchorage, Aventura, Bay Pines, Bellaire, Bellevue, Birmingham, Boise, Charlotte, Chicago, Chula Vista, Columbia, Columbus, Coral Springs, Dallas, DeLand, Denver, Duncansville, Greensboro, Hamilton, Hialeah, Homestead, Houston, Jackson, Kansas City, Katy, Lansing, Largo, Leland, Lewisville, Long Beach, Mandeville, Marietta, Meridian, Miami, Middleburg Heights, Newnan, Oklahoma City, Orchard Park, Oxon Hill, Plantation, Rapid City, Richmond, Round Rock, Saint Clair Shores, Salisbury, Santa Fe, Searcy, Shelby, Sugar Land, Summerville, Tamarac, Tampa, The Woodlands, Troy, Tustin, Walnut Creek, Willowbrook, Winter Park
Age
18 years and over
People
270 worldwide
Run by
Amgen
See details and how to joinNCT07388498
Phase 2Taking people
A Study to Investigate the Clinical Effect and the Safety of PRX-115 Infused Intravenously at Different Dosing Regimens, With and Without Methotrexate, Versus Placebo in Adults Gout Patients (RELEASE)
Where
Anaheim, Clearwater, Columbus, Dearborn, DeLand, Doral, Duncansville, El Cajon, Farmington Hills, Glendale, Hialeah, Houston, La Palma, Little Rock, Long Beach, Miami, Orlando, Palmetto Bay, Sterling Heights, Suffolk, Sugar Land, Tampa, Waco
Age
18 years and over
People
150 worldwide
Run by
Protalix
See details and how to joinNCT07280156
Phase 2Taking people
A Phase 2 Trial of Dotinurad in Xanthine Oxidase Inhibitor (XOI) Intolerant/Uricase Failure Gout Participants
Where
Amarillo, Atlanta, Birmingham, Brooklyn, Charlotte, Chicago, Dallas, Dayton, DeBary, Denver, DeSoto, Flagami, Granada Hills, Hartsdale, Hialeah, Houston, Jupiter, Katy, Lakeland, Las Vegas, Lexington, Margate, Mesquite, Miami, Norfolk, Oxon Hill, Phoenix, Rockville, Saint Clair Shores, San Antonio, Shelby, Sparta, Sterling Heights, Thousand Oaks, Tomball, Troy, Tucson, Tustin, Waco, Wichita Falls
Age
18 years to 75 years
People
90
Run by
Crystalys Therapeutics
See details and how to joinNCT07535034
No phaseTaking people
A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders
Where
Bethesda
Age
1 month to 100 years
People
999
Run by
National Human Genome Research Institute (NHGRI)
See details and how to joinNCT06092346
Phase 4Taking people
SAVE-Care (Sodium Glucose Cotransporter-2 Inhibitors [SGLT2i] As Novel Gout Care) Trial
Where
Boston
Age
18 years to 80 years
People
60
Run by
Massachusetts General Hospital
See details and how to joinNCT06674109
No phaseTaking people
Dose Response of Exercise for Arthritis Management
Where
Columbia
Age
18 years and over
People
285
Run by
University of South Carolina
See details and how to joinNCT06880653
No phaseTaking people
Home Hospital for Suddenly Ill Adults
Where
Boston
Age
18 years and over
People
3,000
Run by
Brigham and Women's Hospital
See details and how to joinNCT03524222
Phase 2/3Taking people
Study of Dapansutrile Tablets in Subjects With an Acute Gout Flare
Where
Amarillo, Ann Arbor, Birmingham, Bothell, Chicago, DeLand, Duncansville, Gainesville, Glendale, Jacksonville, Lexington, Los Angeles, Mesa, Miami, Missoula, New York, Orland Park, Salt Lake City, San Diego, Spokane, Summerville, Tampa, Tarzana
Age
18 years and over
People
300 worldwide
Run by
Olatec Therapeutics, Inc.
See details and how to joinNCT05658575 · EU 2024-518844-20-00
Phase 4Taking people
Purified Cortrophin® Gel Efficacy and Safety Study of 2 Dose Levels in Patients With Acute Gout Flares
Where
Boston
Age
18 years to 90 years
People
150
Run by
Massachusetts General Hospital
See details and how to joinNCT07346079
No phaseTaking people
Improving Gout Care After an ED Visit
Where
Birmingham
Age
18 years to 99 years
People
200
Run by
University of Alabama at Birmingham
See details and how to joinNCT06534554