Taking people in United StatesNo phase

Tests fiber supplement effects on gut and blood vessel health in obesity

Tests inulin fiber supplements in adults with obesity, with or without metabolic risk factors.

Key facts

Who runs it: Ball State University
Where: Muncie, United StatesSee the site
Trial code: NCT07095426
Registry title: Impact of Supplemental Fiber on Gut and Vascular Health Related in Obesity Phenotypes
Status: Recruiting
People taking part: 20 people, planned
Started: 20 May 2025
Expected to end: May 2027
Type of study: Interventional
Treatments tested: inulin
Record updated: 31 July 2025

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults aged 18-55 with a BMI of 30 kg/m2 or higher. They take a fiber supplement for 9 weeks so researchers can study gut and blood vessel health.

Age: 18 to 55 years
Sex: All sexes can join.
Disease stage: BMI of 30 kg/m2 or higher, with either 0-1 or 2 or more risk factors outside normal ranges: blood pressure, blood sugar, triglycerides, HDL-cholesterol. No advanced heart or metabolic disease such as cardiovascular disease or type 2 diabetes.
Earlier treatment: No antibiotics or probiotics in the last month. No weight-loss medications such as Ozempic or Wegovy. No regular anti-inflammatory drugs (more than 2 times a week) unless willing to stop them for 3 days before lab visits.

Main reasons for not taking part

Pregnant or expecting to become pregnant
Postmenopausal women
Advanced heart or metabolic disease, such as cardiovascular disease or type 2 diabetes
Chronic inflammatory condition, such as rheumatoid arthritis, inflammatory bowel disease or diverticulitis
Tobacco or illicit drug use, a pacemaker, or a food allergy or intolerance that prevents taking the fiber supplement

The registry criteria, word for word

Show all 25 criteriaShow less

Who can take part

Participants are 18-55 years old
Participants BMI is ≥30 kg/m2 - this BMI requirement is due to our research aims
Participants have either 0-1 or 2+ of the following risk factors outside of the normal reference ranges: blood pressure, blood sugar, triglycerides, and HDL-cholesterol
Participants are not pregnant or expecting to become pregnant (females only). •Participants are not postmenopausal (females only)
Participants have not been diagnosed with an advanced cardiometabolic condition (e.g., cardiovascular disease, type 2 diabetes)
Participants have not been diagnosed with a chronic inflammatory condition (e.g., rheumatoid arthritis, inflammatory bowel disease, diverticulosis/diverticulitis)
Participants do not regularly take anti-inflammatory drugs (more than 2x week) and are willing to suspend use of these medications for 3 days leading up to in-lab visits
Participants do not take weight-loss medications (e.g., Ozempic, Wegovy)
Participants do not use tobacco products or any illicit drugs
Participants have not used antibiotics or probiotics in the last month
Participants do not have dietary restrictions prohibiting them from consuming the fiber supplement (e.g., food allergies/intolerance)
Participants do not have a pacemaker
Participants are able to lie on their back (supine position) in the dark for at least 10 minutes (related to vascular measurements)

Who cannot take part

Participants take weight-loss medications (e.g., Ozempic, Wegovy)
Participants use tobacco products or any illicit drugs
Participants have been diagnosed with an advanced cardiometabolic condition (e.g., cardiovascular disease, type 2 diabetes)
Participants have been diagnosed with a chronic inflammatory condition (e.g., rheumatoid arthritis, inflammatory bowel disease, diverticulosis/diverticulitis). •Participants regularly take anti-inflammatory drugs (more than 2x week) and are not willing to suspend use of these medications for 3 days leading up to in-lab visits
Participants have dietary restrictions prohibiting them from consuming the fiber supplement (e.g., food allergies/intolerance)
Participants are not 18-55 years old
Participants BMI is not ≥30 kg/m2 - this BMI requirement is due to our research aims
Participants do not have either 0-1 or 2+ of the following risk factors outside of the normal reference ranges: blood pressure, blood sugar, triglycerides, and HDL-cholesterol
Participants are pregnant or expecting to become pregnant (females only)
Participants are postmenopausal (females only)
Participants have used antibiotics or probiotics in the last month
Participants have a pacemaker

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

Are you between 18 and 55 years old?

Where in United States

Health Professions BuildingMuncie, United StatesContact: Bryant Keirns, PhDTaking people

About the trial

What the trial wants to find out

Based on prior research, the investigators are interested in whether an intervention targeting gut health (supplemental fiber for 9 weeks total) will improve vascular health in individuals with obesity. Additionally, the investigators are interested in if this response differs based on whether individuals with obesity have very few heart disease risk factors or several heart disease risk factors.

The group in the trial

Inulin SupplementTreatment being tested
Participants will consume 6g of pre-portioned powdered inulin from chicory root daily for one week followed by 12g daily for eight weeks. Participants will fully dissolve it into a habitual cool or room temperature beverage to drink around the same time each day.
Treatment: inulin