Feasibility Study of 'SuperBrain BOOM' for Mild Cognitive Impairment Patients

Who can take part

• Age: Between 50 and 85 years old
• Meets all of the core clinical criteria for suspected Mild Cognitive Impairment (MCI) according to the National Institute on Aging-Alzheimer's Association (NIA-AA) guidelines as of the screening date:; Concerns of the participant or caregiver regarding cognitive decline compared to prior functioning; Impairment in at least one cognitive domain; Preserved independence in overall daily living activities; No dementia
• Has one or more of the following neuropsychological test results within one year of the screening date, with delayed recall scores in the memory domain below the mean -1.0 standard deviation according to age- and education-adjusted normative data:; Seoul Neuropsychological Screening Battery 2nd Edition (SNSB-II); Korean version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD-K); Literacy Independent Cognitive Assessment (LICA)
• As of the screening date, has a Korea-Mini Mental State Examination (K-MMSE-2) score that corresponds to at least -1.5 standard deviations below the mean based on age- and education-adjusted normative data
• As of the screening date, has a Global Clinical Dementia Rating (CDR) score of 0.5, with a memory score of either 0.5 or 1
• Capable of using a tablet or smartphone with training, or has a research partner who can assist with using a tablet or smartphone
• Has a caregiver who regularly contacts the participant:; -A caregiver who is able to support the participant (monitor compliance and report participant status) and spends at least 8 hours per week with the participant during the trial period
• The participant provides written informed consent to participate in the study

Who cannot take part

• Vascular surgery or stent placement within the past year
• Presence of psychiatric disorders, such as major depression
• Dementia
• Other neurodegenerative diseases, such as Parkinson's disease
• Malignant tumors within the past 5 years that have not been declared cured
• Severe or unstable symptomatic cardiovascular disease
• Evidence of severe or unstable physical conditions, such as acute or severe asthma, active peptic ulcers, severe liver disease, kidney disease requiring dialysis, or any other medical conditions that may interfere with completing the clinical trial
• Severe vision impairment, severe hearing loss, or communication difficulties that would prevent the participant from undergoing the intervention or efficacy assessments
• Abnormal findings in clinical pathology tests related to cognitive decline, as determined by the clinical investigator (e.g., significant thyroid dysfunction, vitamin B12 or folate deficiency, neurosyphilis, etc.)
• The investigator's judgment that the participant is unlikely to cooperate fully with the study
• The investigator's judgment that the participant has difficulty safely participating in an exercise-based intervention program
• Participation in another interventional clinical trial