Two antiseptic washes compared for wound healing after hip replacement surgery
Compares povidone-iodine and chlorhexidine washes for wound healing in people having hip replacement.
Key facts
- Who runs it
- F. Johannes Plate
- Where
- Monroeville and Pittsburgh, United StatesSee the 2 sites
- Trial code
- Registry title
- Influence of Antiseptic Washes on Wound Healing Complications After THA
- Status
- Recruiting
- People taking part
- 420 people, planned
- Started
- 9 Oct 2025
- Expected to end
- 1 Jan 2028
- Type of study
- Interventional, 2 groups
- Treatments tested
- lavage chlorhexidine
- lavage povidone-iodine
- Record updated
- 5 February 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with hip osteoarthritis or avascular necrosis of the femoral head who are planned for total hip replacement. It compares two wound washing solutions.
- Age
- 18 Years and older
- Sex
- All sexes can join
- Disease stage
- Hip osteoarthritis or avascular necrosis (bone death) of the femoral head, where total hip replacement is planned
- Earlier treatment
- Non-surgical (conservative) treatment must have failed
Main reasons for not taking part
- Reported or documented allergy to chlorhexidine or povidone-iodine
The registry criteria, word for word
Show all 2 criteriaShow less
Who can take part
- osteoarthritis or avascular necrosis of the femoral head, failed conservative management, indicated for total hip replacement
Who cannot take part
- reported or documented allergy to chlorhexidine or povidone-iodine
Where in United States
- UPMC EastMonroeville, United StatesContact: Dana Farrell, BS,PMPTaking people
- UPMC ShadysidePittsburgh, United StatesContact: Dana Farrell, BS,PMPTaking people
About the trial
What the trial wants to find out
The purpose of this research trial is to evaluate the effect of two types of washing solutions on wound healing after total hip replacement surgery. Washing solutions are used routinely during total hip replacements to clean the wound after the components have been placed and the wound is about to be closed with sutures. It is currently not known which washing solution may be better for wound healing and whether a certain solution decreases the risk of wound healing complications after total hip replacement. Therefore, this research trial is being conducted.
Read full original descriptionShow less
Study participants will be randomized into one of two groups: washing the surgical wound with povidone-iodine solution (Surgiphor, Becton Dickinson, Franklin Lakes, NJ) or chlorhexidine solution (Irrisept, Irrimax Corporation, Lawrenceville, GA). All patients will undergo standard of care total hip replacements without any other change in surgery. The best type of solution that cleans the wound and potentially leads to better wound healing is unknown. This study will evaluate whether there is difference in surgical wound healing between the two washing solutions. The study will pay for the washing solutions. Patients will follow up for standard postoperative visits. At the 2-week and 6-week visits, pictures of the surgical incision will be taken and saved in the electronic medical record and evaluated in a standardized way for healing of the incision and the appearance of the scar. Postoperative complications and returns to the hospital or additional surgeries will be collected from the electronic medical record.
The 2 groups in the trial
- Chlorhexidine washing solutionTreatment being tested
Following component implantation a 3-minute chlorhexidine lavage followed by saline lavage will be performed.
Treatment: lavage chlorhexidine
- Povidone-iodine washing solutionTreatment being tested
Following component implantation a 3-minute povidone-iodine lavage followed by saline lavage will be performed.
Treatment: lavage povidone-iodine
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Comparison of Wound Healing Complications After Anterior Total Hip Arthroplasty Using Povidone-iodine or Chlorhexidine as Antiseptic Wash
- Plain-language title
- Two antiseptic washes compared for wound healing after hip replacement surgeryGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 14 November 2026.
- Record updated
- 5 February 2026