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Breathing Muscle Training Device Tested for Blood Pressure in Adults

Tests a breath-strength training device in adults with raised systolic blood pressure.

Key facts

Who runs it
University of Minnesota
Where
Minneapolis, United StatesSee the site
Trial code
Registry title
Dose-Response Effects of Inspiratory Muscle Strength Training on Blood Pressure and Vascular Function
Status
Recruiting
People taking part
144 people, planned
Started
24 Oct 2025
Expected to end
31 Mar 2027
Type of study
Interventional, 3 groupsOne group gets an existing treatment, for comparison.
Treatments tested
  • POWERbreathe K5
Record updated
10 November 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with a resting top blood pressure number (systolic) of 120 mmHg or higher, and no serious heart or metabolic disease. It tests breathing muscle training for 6 weeks.

Age
18 years or older
Sex
All sexes can join
Disease stage
Resting systolic blood pressure of 120 mmHg or higher, measured at 2 screening visits

Main reasons for not taking part

  • History of heart or blood vessel disease
  • Serious metabolic disease
  • Ruptured eardrum or other ear condition
  • Recent abdominal surgery or abdominal hernia
  • Smoking or vaping in the past year

The registry criteria, word for word

Show all 15 criteriaShow less

Who can take part

  • Age ≥18 years
  • Resting SBP ≥120 mmHg as measured during screening 1 \& 2
  • Free from serious CV or metabolic diseases as identified by self-report and blood chemistry analysis
  • No contraindications to IMST (recent abdominal surgery, ruptured eardrum, asthma with very low symptom perception, fractured ribs, or pneumothorax)
  • Language: English-speaking, with ability to comprehend study materials and instructions
  • Pre-visit Compliance: Willing to comply with pre-visit instructions (avoiding food and caffeine ≥ 3 hours, vigorous exercise, alcohol, and non-prescribed medications ≥ 24 hours) prior to each measurement visit
  • Lifestyle: Non-smokers (defined as self-report of not smoking cigarettes or vaping over the past year)

Who cannot take part

  • Recent abdominal surgery or presence of an abdominal hernia
  • Self-report of history of cardiovascular disease, or conditions affecting the ear (e.g., ruptured eardrum)
  • Ruptured eardrum or any other condition of the ear
  • Current respiratory conditions such as a cold, sinusitis, or respiratory tract infection (participants may be included once they recover from the respiratory condition)
  • Asthma with very low symptom perception, frequent severe exacerbations, or abnormally low perception of dyspnea
  • Markedly elevated left ventricular end-diastolic volume and pressure
  • Female-Specific: Pregnant or planning to become pregnant during the study period
  • Compliance: Unable or unwilling to comply with pre-visit restrictions (e.g., avoiding caffeine, alcohol, and exercise within specified hours before visits)

Where in United States

  • University of MinnesotaMinneapolis, United StatesContact: Olivia RuhlandTaking people

About the trial

What the trial wants to find out

This study will assess the dose-response effects of Inspiratory Muscle Strength Training (IMST) in adults with above-normal systolic blood pressure over a 6-week period.

The 3 groups in the trial

  • 15 Breaths/ DayExisting treatment, for comparison

    All sessions will be performed at 75% of each participant's PI max 7 days per week, for 6 weeks, using the POWERbreathe K5 device. Each session will take approximately 3-10 minutes depending on the assigned dose group.

    Treatment: POWERbreathe K5

  • 30 Breaths/ DayExisting treatment, for comparison

    All sessions will be performed at 75% of each participant's PI max 7 days per week, for 6 weeks, using the POWERbreathe K5 device. Each session will take approximately 3-10 minutes depending on the assigned dose group.

    Treatment: POWERbreathe K5

  • 45 Breaths/ DayExisting treatment, for comparison

    All sessions will be performed at 75% of each participant's PI max 7 days per week, for 6 weeks, using the POWERbreathe K5 device. Each session will take approximately 3-10 minutes depending on the assigned dose group.

    Treatment: POWERbreathe K5

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Dose-Response Effects of Inspiratory Muscle Strength Training on Blood Pressure and Vascular Function
Plain-language title
Breathing Muscle Training Device Tested for Blood Pressure in AdultsGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Record updated
10 November 2026