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AI Software Tested With Brain MRI Scans to Track Multiple Sclerosis

Tests AI software reading brain MRI scans in adults with multiple sclerosis.

Key facts

Who runs it
Queen Mary University of London
Where
London, United KingdomSee the site
Trial code
Registry title
Artificial Intelligence-Assisted Magnetic Resonance Imaging for Quality, Efficiency and Equity in the National Health Service (NHS) Care of Multiple Sclerosis
Status
Recruiting
People taking part
1,336 people, planned
Started
14 Jun 2025
Expected to end
14 Apr 2027
Type of study
Interventional, 2 groupsOne group gets no study treatment, for comparison.
Treatments tested
  • AI software
Record updated
12 August 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with a first episode suggesting multiple sclerosis (MS) or a confirmed MS diagnosis, who are on an MS treatment pathway and having a head MRI scan.

Age
18 to 99 years
Sex
All sexes can join
Disease stage
Clinically isolated syndrome suggestive of demyelination, or a definite diagnosis of MS
Earlier treatment
Must be on a disease-modifying treatment (DMT) pathway for MS

Main reasons for not taking part

  • Taking part in a randomised controlled drug trial (CTIMP)
  • Not having access to a smartphone, tablet or computer

The registry criteria, word for word

Show all 5 criteriaShow less

Who can take part

  • Clinically Isolated Syndrome suggestive of demyelination (CIS) or definitive diagnosis of MS
  • Undergoing MRI head investigation
  • On an MS DMT pathway
  • Access to a smartphone, tablet or computer

Who cannot take part

  • patients with Multiples Sclerosis participating in a randomised controlled CTIMP (participating in a single arm study may be included, provided this is in line with the other protocol)

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 18 and 99 years old?

Where in United Kingdom

  • Barts Health NHS TrustLondon, United KingdomContact: Husna AhmedTaking people

About the trial

What the trial wants to find out

Multiple Sclerosis (MS) is a long-term disease that affects over 150,000 people in the UK. Starting treatment early is important for managing Multiple Sclerosis (MS). It is also essential to monitor the treatment to see if it is working and to switch treatments if needed.

Read full original descriptionShow less

Magnetic resonance imaging (MRI) is the only accepted tool to monitor how well the treatment is working. Current evaluation of brain Magnetic resonance imaging (MRI) scans requires visual inspection, of which sensitivity is degraded by human, and technical factors, such as lack of time, fatigue of radiologists, and lack of standardization of image acquisition protocols across the National Health Service (NHS). MRI-readings can be significantly enhanced by artificial intelligence (AI)-assistive software. Evidence suggests the rate of new lesion detection to be 3 - 4 times higher when using assistive software compared to visual inspection of MRI scans.

In this study, an Artificial Intelligence (AI) software called "icobrain ms." developed by the company "icometrix" (Leuven, Belgium) is tested. This tool helps track MS by measuring changes in the brain using MRI scans. The AI can highlight problem areas and create reports that doctors can use to make better decisions about participants' treatment. The aim of the study is to prove that icobrain ms can be used to assist the neuro-radiologist with their visual assessment of MRI scans by a radiologist, and that it will help clinicians make more informed decisions about participants' current MS treatment.

The 2 groups in the trial

  • Radiological reading by a neuroradiologist assisted by icobrain ms.Treatment being tested

    icobrain ms Artificial Intelligence (AI) assistive software

    Treatment: AI software

  • Radiological reading by a neuroradiologistNo study treatment, for comparison

    Standard of Care

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Artificial Intelligence-Assisted Magnetic Resonance Imaging for Quality, Efficiency and Equity in the National Health Service (NHS) Care of Multiple Sclerosis
Plain-language title
AI Software Tested With Brain MRI Scans to Track Multiple SclerosisGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Fit questions
Built from NCT07111637, who can take part
Record updated
12 August 2026