Multiple sclerosis trials in United Kingdom

In United Kingdom 24 Also abroad 506

24 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 4Taking people
Individualised Cryoneurolysis to Treat Pain in the Context of Spasticity in the Upper and Lower Extremities
Where
Oxford
Age
18 years and over
People
50
Run by
Oxford University Hospitals NHS Trust
See details and how to joinNCT07303582
No phaseTaking people
A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)
Where
London
Age
18 years and over
People
2,000 worldwide
Run by
TG Therapeutics, Inc.
See details and how to joinNCT06433752
No phaseTaking people
REAL-MS: Observational Database Study of AHSCT and MS Therapies
Where
London
Age
18 years and over
People
2,000
Run by
Imperial College London
See details and how to joinNCT07899502
Phase 3Taking people
Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.
Where
Leeds, London, Sheffield, Swansea
Age
40 years to 70 years
People
400 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT06846281 · EU 2023-509275-17-00
No phaseTaking people
OPM- MEG in Non-immune And iMmune-medIated Neurological Disease
Where
Birmingham
Age
2 years to 16 years
People
90
Run by
Aston University
See details and how to joinNCT07689682
Phase 1Taking people
Obe-cel in Refractory Progressive Forms of Multiple Sclerosis
Where
Cambridge, Edinburgh, London, Sheffield
Age
18 years to 60 years
People
24 worldwide
Run by
Autolus Limited
See details and how to joinNCT07139743 · EU 2024-519552-93-00
Phase 3Taking people
A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis
Where
Brighton, Bristol, Coventry, Glasgow, Leeds, London, Nottingham, Romford, Stoke-on-Trent
Age
18 years to 65 years
People
1,275 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT07225504
No phaseTaking people
Identifying Immune Biomarkers of Disease and Disease Control in Autoimmune Neurological Disease Using Autologous Haematopoietic Stem Cell Transplantation
Where
Sheffield
Age
16 years and over
People
15
Run by
Sheffield Teaching Hospitals NHS Foundation Trust
See details and how to joinNCT06195800
Phase 2Taking people
A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of RO7268489 as Add-on Therapy to Ocrelizumab, in Participants With Progressive Forms of Multiple Sclerosis (MS)
Where
Cardiff, Glasgow, London, Salford, Swansea, Truro
Age
18 years to 60 years
People
360 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT07282574 · EU 2025-521636-10-00
No phaseTaking people
Digital App for Speech & Health Monitoring
Where
Edinburgh
Age
16 years and over
People
150
Run by
University of Edinburgh
See details and how to joinNCT06450418
Phase 1Taking people
SIZOMUS Safety of Ixazomib Targeting Plasma Cells in Multiple Sclerosis
Where
London
Age
18 years to 65 years
People
72
Run by
Queen Mary University of London
See details and how to joinNCT03783416
Phase 1Taking people
An Open-label Study of AZD0120 in Adults With Multiple Sclerosis
Where
Cambridge, London
Age
18 years to 60 years
People
24 worldwide
Run by
AstraZeneca
See details and how to joinNCT07224373
No phaseTaking people
Artificial Intelligence-Assisted Magnetic Resonance Imaging for Quality, Efficiency and Equity in the National Health Service (NHS) Care of Multiple Sclerosis
Where
London
Age
18 years to 99 years
People
1,336
Run by
Queen Mary University of London
See details and how to joinNCT07111637
No phaseTaking people
Pregnancy Exposure Registry for Vumerity (Diroximel Fumarate)
Where
Salford
People
908 worldwide
Run by
Biogen
See details and how to joinNCT05658497
No phaseNot yet taking people in United Kingdom
Early Prediction of Outcomes Following Optic Neuritis: Development and Acceptability of a Prognostic Tool
Where
London
Age
16 years and over
People
180
Run by
King's College London
See details and how to joinNCT07704294
Phase 2Taking people
A Study to Investigate Multiple Sclerosis Relapse Prevention With mRNA-1195 Compared With Placebo in Participants Aged 18 to ≤55 Years
Where
Bristol, Cardiff, Edinburgh, Glasgow, London, Newcastle upon Tyne, Sheffield
Age
18 years to 55 years
People
180 worldwide
Run by
ModernaTX, Inc.
See details and how to joinNCT06735248 · EU 2024-517949-13-00
No phaseEnrolling by invitation
Multiple Sclerosis: FutureMS-2 - an Observational Cohort and Scottish Precision Medicine Study
Where
Aberdeen, Dundee, Edinburgh, Glasgow, Inverness
Age
18 years and over
People
440
Run by
University of Edinburgh
See details and how to joinNCT06001138
No phaseEnrolling by invitation
OCTive: A New Horizon in MS Digital Solution
Where
Exeter
Age
18 years to 80 years
People
10
Run by
University of Exeter
See details and how to joinNCT07582653
No phaseTaking people
Longitudinal Assessment of Iron Rims in MS Lesions
Where
Nottingham
Age
16 years and over
People
100
Run by
Nottingham University Hospitals NHS Trust
See details and how to joinNCT05123443
No phaseTaking people
Hesperidin RCT in MS
Where
Swansea
Age
18 years and over
People
60
Run by
Swansea University
See details and how to joinNCT07452562
Phase 2Taking people
Natalizumab for the Treatment of People With Inflammatory Demyelination Suggestive of Multiple Sclerosis, or Definite Multiple Sclerosis, at First Presentation (AttackMS)
Where
London
Age
18 years to 55 years
People
40
Run by
Queen Mary University of London
See details and how to joinNCT05418010
No phaseNot yet taking people in United Kingdom
Optimising Access to Vocational Rehabilitation for People With Multiple Sclerosis
Where
Nottingham
Age
18 years to 66 years
People
60
Run by
University of Nottingham
See details and how to joinNCT06966115
No phaseEnrolling by invitation
Metabolic Imaging of Neurological Disease
Where
Oxford
Age
Up to 99 years
People
250
Run by
University of Oxford
See details and how to joinNCT06900244
No phaseTaking people
Assessing NHS ImplemeNTation of an onlinE Resilience Training Acceptance and Commitment Therapy (ACT) Programme to Prevent Job Loss in Multiple Sclerosis
Where
Leeds
Age
18 years to 66 years
People
300
Run by
The Leeds Teaching Hospitals NHS Trust
See details and how to joinNCT06728956