Synovial Fluid Withdrawal or PRP Injection For Acute ACL Tears and Cytokines
Key facts
- Who runs it
- Rush University Medical Center
- Where
- Chicago, United StatesSee the site
- Trial code
- Status
- Not yet recruiting
- People taking part
- 99 people, planned
- Started
- Sept 2026
- Expected to end
- Dec 2028
- Type of study
- Interventional, 3 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Synovial Fluid withdrawal at the preoperative clinic visit
- Platelet-Rich Plasma (PRP) preparation and injection
- Synovial fluid withdrawal at the time of surgery
- 3mL synovial fluid withdrawn at the preoperative visit
- Record updated
- 18 June 2026
Who can take part
- Age
- 18 years to 50 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 9 criteriaShow less
Who can take part
- Age 18 - 50
- English-speaking
- Clinical evidence of ACL rupture with swelling
- Participant must be undergoing ACL reconstruction surgery
Who cannot take part
- Previous traumatic ipsilateral (same side) knee injury consistent with chronic ACL tear or prior ACL surgery
- History of hemophilia or inflammatory arthropathy (e.g., rheumatoid arthritis)
- Age <18 or >50
- Presentation >3 weeks after initial injury
- > Kellgren-Lawrence grade 2 changes on preoperative x-ray
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 50 years old?
Where in United States
- Rush University Medical CenterChicago, United StatesContact: Adam Yanke, MD, PhDNo longer taking part
About the trial
What the trial wants to find out
The purpose of this study is to determine what effects the withdrawal of excess knee joint fluid or the injection of a factor from the blood has on swelling after a sudden anterior cruciate ligament (ACL) rupture of the knee.
The 3 groups in the trial
- Two Synovial Fluid WithdrawalsExisting treatment, for comparison
Subjects randomized to Arm 1 will have 2 synovial fluid withdrawals; one at the preoperative clinic visit and one at the time of surgery
Treatment: Synovial Fluid withdrawal at the preoperative clinic visit and Synovial fluid withdrawal at the time of surgery
- Platelet-Rich Plasma (PRP) and Two Synovial Fluid WithdrawalsTreatment being tested
Subjects randomized to ARM 2 will have 2 synovial fluid withdrawals one at the preoperative visit and one at the time of surgery. Platelet-Rich Plasma (PRP) preparation and injection will happen at the preoperative clinic visit.
Treatment: Synovial Fluid withdrawal at the preoperative clinic visit, Platelet-Rich Plasma (PRP) preparation and injection, and Synovial fluid withdrawal at the time of surgery
- 3mL Synovial Fluid Withdrawal and Synovial Fluid Withdrawal at the Time of SurgeryOther group
Subjects randomized to Arm 3 will have 3mL withdrawal of synovial fluid at the preoperative visit and 1 synovial fluid withdrawal at the time of surgery
Treatment: Synovial fluid withdrawal at the time of surgery and 3mL synovial fluid withdrawn at the preoperative visit
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Does Arthrocentesis and PRP For Acute ACL Tears With Hemarthrosis Decrease Inflammatory Cytokines At Time Of Surgery: A Prospective Randomized Control Trial (RCT)
- Fit questions
- Built from NCT07142369, who can take part
- Record updated
- 18 June 2026