Diaphragm Ultrasound During Breathing Support in People With ALS
Checks diaphragm movement with ultrasound, with and without breathing support, in adults with ALS.
Plain-language title generated from the registry record
Registry title: Dynamic Impact of NIV on Diaphragmatic Ultrasound in Patients With Amyotrophic Lateral Sclerosis
Key facts
- Where
- Grenoble, FranceSee the site
Where in France
- CHU Grenoble AlpesGrenoble, FranceNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Hospital, Grenoble
- Trial code
- NCT07170865
- Record updated
- 12 September 2025
- Original description
The goal of this pilot observational study is to learn about the dynamic impact of the non invasive ventilation on the diaphragm in patient with amyotrophic lateral sclerosis. The main question it aims to answer : can diaphragmatic ultrasound detect differences in diaphragmatic motion (diaphragmactic excursion and diaphragmatic thickening between spontaneous breathing and non-invasive ventilation ?Read full original descriptionShow less
Assessment of the Dynamic Impact of Non-Invasive Ventilation on Diaphragmatic Ultrasound in Patients With Amyotrophic Lateral Sclerosis
The goal of this pilot observational study is to learn about the dynamic impact of the non invasive ventilation on the diaphragm in patient with amyotrophic lateral sclerosis. The main question it aims to answer : can diaphragmatic ultrasound detect differences in diaphragmatic motion (diaphragmactic excursion and diaphragmatic thickening between spontaneous breathing and non-invasive ventilation ?
Participants will receive diaphragmatic ultrasound assessments both under spontaneous breathing and during non-invasive ventilation on their day hospital evaluation for ventilatory support.
Inclusion: Adult patient (≥18 years old); Diagnosis of bulbar or spinal amyotrophic lateral sclerosis (ALS) established by a neurologist; Indication for non-invasive ventilation (NIV) confirmed by the referring pulmonologist for daytime and/or nocturnal alveolar hypoventilation.
Exclusion: Continuous (24-hour) non-invasive ventilation; Patient refusal to participate; Individual under legal guardianship or judicial protection.