Intermittent Hypoxia Training for Brain Blood Vessel Health in Older Adults
Tests intermittent low-oxygen breathing in older adults with type 2 diabetes.
Key facts
- Who runs it
- Darren P Casey
- Where
- Iowa City, United StatesSee the site
- Trial code
- Registry title
- IH, Brain Health, and T2D
- Status
- Recruiting
- People taking part
- 80 people, planned
- Started
- 22 Sept 2025
- Expected to end
- 30 Jun 2028
- Type of study
- Interventional, 3 groupsOne group gets a sham (pretend) treatment, for comparison.
- Treatments tested
- Intermittent Hypoxia 1 (IH1)
- Intermittent Hypoxia 2 (IH2)
- SHAM - normoxia
- Record updated
- 13 March 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for older adults aged 60 to 85, with type 2 diabetes or without diabetes, to test intermittent hypoxia for brain blood vessel health.
- Age
- 60 to 85 years
- Sex
- All sexes can join.
- Disease stage
- One group has documented type 2 diabetes. The other group has no diabetes. Both need a MoCA test score of 26 or higher.
- Biomarker or test result
- For people with diabetes, HbA1c must be between 6.5% (48 mmol/mol) and 10.0% (86 mmol/mol).
Main reasons for not taking part
- Type 2 diabetes diagnosed less than 1 year before enrollment
- Heart attack or stroke in the last year
- Symptomatic coronary artery disease or heart failure, or uncontrolled hypertension
- Obstructive sleep apnea, pulmonary disease or dementia
- Kidney impairment (eGFR under 60 ml/min), body mass index over 40 kg/m2, or smoking within the past year
The registry criteria, word for word
Show all 29 criteriaShow less
Who can take part
- Willing and able to provide written, signed informed consent after the nature of the study has been explained, and prior to any research-related procedures
- Age is > or = 60 and < or = 85 years of age
- Documented Type 2 diabetes
- Scoring 26 or higher on the MoCA test
- Willing and able to provide written, signed informed consent after the nature of the study has been explained, and prior to any research-related procedures
- Age is > or = 60 and < or = 85 years of age
- Scoring 26 or higher on the MoCA test
Who cannot take part
- diagnosis of type 2 diabetes < 1 year prior to enrollment
- incident cardiovascular events in the last year (heart attack, stroke)
- symptomatic coronary artery disease and/or heart failure
- uncontrolled hypertension
- pulmonary disease
- dementia
- smoking or history of smoking within past one year; 30 nondiabetic control subjects will also be studied
- Diagnosis of diabetes (Type 1 or Type 2)
- incident cardiovascular events in the last year (heart attack, stroke)
- symptomatic coronary artery disease and/or heart failure
- uncontrolled hypertension
- pulmonary disease
- dementia
- smoking or history of smoking within past one year
- HbA1c <6.5% or >10.0%
- renal impairment with creatinine clearance (eGFR) of <60 ml/min
- renal impairment with creatinine clearance (eGFR) of <60 ml/min
- body mass index > 40 kg/m 2
- obstructive sleep apnea
- body mass index > 40 kg/m2
- obstructive sleep apnea
Other criteria
- For 30 patients with documented Type 2 diabetes
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 60 and 85 years old?
Where in United States
- University of IowaIowa City, United StatesContact: Darren P Casey, PhD (principal investigator)Taking people
About the trial
What the trial wants to find out
The purpose of this study is to use a randomized, placebo-controlled study design to rigorously examine the therapeutic potential of intermittent hypoxia (IH) for improving cerebrovascular health in older adults with and without type 2 diabetes mellitus (T2DM).
The 3 groups in the trial
- Intermittent Hypoxia 1Treatment being tested
Participants will receive intermittent hypoxia (5 cycles of normoxia/hypoxia over 50 minutes).
Treatment: Intermittent Hypoxia 1 (IH1)
- NormoxiaSham treatment, for comparison
Participants will receive normoxia over 50 minutes.
Treatment: SHAM - normoxia
- Intermittent Hypoxia 2Treatment being tested
Participants will receive intermittent hypoxia (5 cycles of normoxia/hypoxia over 50 minutes).
Treatment: Intermittent Hypoxia 2 (IH2)
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Intermittent Hypoxia Training and Cerebrovascular Health in Older Adults With Type 2 Diabetes
- Plain-language title
- Intermittent Hypoxia Training for Brain Blood Vessel Health in Older AdultsGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT07173543, who can take part
- Record updated
- 13 March 2026