Taking people in United StatesPhase 3
Tests zilebesiran in adults with high-risk heart disease and high blood pressure
Tests zilebesiran against placebo in adults with uncontrolled high blood pressure and heart risk.
Plain-language title generated from the registry record
Registry title: Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease
Key facts
- Where
- Albuquerque, Allen, Amarillo, Arlington, Arlington Heights, Atlanta, Austin, Avon, Baltimore, Beaumont, Beavercreek, Bellevue, Beltsville, Beverly Hills, Birmingham, Boca Raton, Bountiful, Bowie, Bowling Green, Brandon, Brick, Bridgeport, Bridgewater, Brunswick, Camp Hill, Canton, Carmel, Carrollton, Chandler, Charleston, Chattanooga, Chicago, Chula Vista, Cincinnati, Columbia, Columbus, Conyers, Covina, Dallas, Danville, Dayton, Duncanville, Durham, Edmond, El Paso, Escondido, Euless, Evansville, Fairfax, Fairhope, Falls Church, Fargo, Fayetteville, Fleming Island, Flemington, Flint, Foley, Fort Lauderdale, Fremont, Gilbert, Glendale, Greenfield, Greenville, Greer, Hammond, Hazel Crest, Hialeah, High Point, Hinesville, Hollywood, Homestead, Horsham, Houston, Humble, Huntington Beach, Huntsville, Hutchinson, Jackson, Jacksonville, Jensen Beach, Johns Creek, Kansas City, Katy, Kenosha, Kings Mountain, Kingwood, Knoxville, La Jolla, Lafayette, Lancaster, Lanham, Lansing, Laredo, Las Vegas, Lawrenceville, Layton, Leesburg, Lexington, Lima, Linwood, Little Rock, Long Beach, Lynwood, Macon, Manassas, Maumee, McAllen, McKinney, Media, Melbourne, Mesa, Mesquite, Metairie, Miami, Midland, Missouri City, Monroe, Moore, Moraine, New Orleans, New Windsor, Newhall, Newport News, Norfolk, Norman, North Massapequa, Northridge, Oak Brook, Oklahoma City, Olive Branch, Omaha, Opelousas, Orland Park, Orlando, Palm Springs, Paris, Pasadena, Peoria, Petoskey, Philadelphia, Phoenix, Plano, Port Arthur, Port Gibson, Portsmouth, Poughkeepsie, Richfield, Richmond, Ridgeland, Riverhead, Rockville, Rosedale, Saint Cloud, Saint Paul, Salt Lake City, San Antonio, San Diego, San Dimas, San Ramon, Saratoga Springs, Sheffield, Shelby, Sherman, Shreveport, Sioux Falls, Slidell, South Bend, Southfield, Springfield, St Louis, Statesville, Stockton, Stonecrest, Stony Brook, Suffolk, Sugar Land, Sun City, Sun City West, Suwanee, Tampa, Tarzana, Tempe, The Bronx, Thomasville, Tinley Park, Toluca Lake, Tomball, Topeka, Torrance, Troy, Tucson, Tupelo, Tustin, Uniontown, Valparaiso, Versailles, Vista, Waco, Walnut Creek, Waterbury, Wellington, West Seneca, Westfield, Wheat Ridge, Whiteland, Wichita, Winchester, Winston-Salem, Winter Park, Yuma, and Zachary, United StatesSee the 211 sites
- Phase
- Phase 3
Where in United States
- AlbuquerqueAlbuquerque, United StatesTaking people
- AllenAllen, United StatesTaking people
- AmarilloAmarillo, United StatesTaking people
- ArlingtonArlington, United StatesTaking people
- Arlington HeightsArlington Heights, United StatesNo longer taking part
- AtlantaAtlanta, United StatesTaking people
- AustinAustin, United StatesTaking people
- AvonAvon, United StatesTaking people
- BaltimoreBaltimore, United StatesTaking people
- BeaumontBeaumont, United StatesTaking people
- BeavercreekBeavercreek, United StatesTaking people
- BellevueBellevue, United StatesNo longer taking part
- BeltsvilleBeltsville, United StatesTaking people
- Beverly HillsBeverly Hills, United StatesTaking people
- BirminghamBirmingham, United StatesTaking people
- Boca RatonBoca Raton, United StatesTaking people
- BountifulBountiful, United StatesTaking people
- BowieBowie, United StatesTaking people
- Bowling GreenBowling Green, United StatesTaking people
- BrandonBrandon, United StatesTaking people
- BrickBrick, United StatesTaking people
- BridgeportBridgeport, United StatesTaking people
- BridgewaterBridgewater, United StatesTaking people
- BrunswickBrunswick, United StatesTaking people
- Camp HillCamp Hill, United StatesTaking people
- CantonCanton, United StatesTaking people
- CarmelCarmel, United StatesTaking people
- CarrolltonCarrollton, United StatesTaking people
- ChandlerChandler, United StatesTaking people
- CharlestonCharleston, United StatesTaking people
- ChattanoogaChattanooga, United StatesTaking people
- ChicagoChicago, United StatesTaking people
- Chula VistaChula Vista, United StatesTaking people
- CincinnatiCincinnati, United StatesTaking people
- ColumbiaColumbia, United StatesTaking people
- ColumbusColumbus, United StatesTaking people
- ConyersConyers, United StatesTaking people
- CovinaCovina, United StatesTaking people
- DallasDallas, United StatesTaking people
- DanvilleDanville, United StatesTaking people
- DaytonDayton, United StatesTaking people
- DuncanvilleDuncanville, United StatesTaking people
- DurhamDurham, United StatesTaking people
- EdmondEdmond, United StatesTaking people
- El PasoEl Paso, United StatesTaking people
- EscondidoEscondido, United StatesTaking people
- EulessEuless, United StatesTaking people
- EvansvilleEvansville, United StatesTaking people
- FairfaxFairfax, United StatesTaking people
- FairhopeFairhope, United StatesTaking people
- Falls ChurchFalls Church, United StatesTaking people
- FargoFargo, United StatesNo longer taking part
- FayettevilleFayetteville, United StatesTaking people
- Fleming IslandFleming Island, United StatesTaking people
- FlemingtonFlemington, United StatesTaking people
- FlintFlint, United StatesTaking people
- FoleyFoley, United StatesTaking people
- Fort LauderdaleFort Lauderdale, United StatesTaking people
- FremontFremont, United StatesTaking people
- GilbertGilbert, United StatesTaking people
- GlendaleGlendale, United StatesNo longer taking part
- GreenfieldGreenfield, United StatesTaking people
- GreenvilleGreenville, United StatesTaking people
- GreerGreer, United StatesTaking people
- HammondHammond, United StatesTaking people
- Hazel CrestHazel Crest, United StatesTaking people
- HialeahHialeah, United StatesTaking people
- High PointHigh Point, United StatesTaking people
- HinesvilleHinesville, United StatesTaking people
- HollywoodHollywood, United StatesTaking people
- HomesteadHomestead, United StatesTaking people
- HorshamHorsham, United StatesTaking people
- HoustonHouston, United StatesTaking people
- HumbleHumble, United StatesTaking people
- Huntington BeachHuntington Beach, United StatesTaking people
- HuntsvilleHuntsville, United StatesTaking people
- HutchinsonHutchinson, United StatesTaking people
- JacksonJackson, United StatesTaking people
- JacksonvilleJacksonville, United StatesTaking people
- Jensen BeachJensen Beach, United StatesTaking people
- Johns CreekJohns Creek, United StatesTaking people
- Kansas CityKansas City, United StatesTaking people
- KatyKaty, United StatesTaking people
- KenoshaKenosha, United StatesTaking people
- Kings MountainKings Mountain, United StatesTaking people
- KingwoodKingwood, United StatesTaking people
- KnoxvilleKnoxville, United StatesTaking people
- La JollaLa Jolla, United StatesTaking people
- LafayetteLafayette, United StatesNo longer taking part
- LancasterLancaster, United StatesTaking people
- LanhamLanham, United StatesTaking people
- LansingLansing, United StatesTaking people
- LaredoLaredo, United StatesTaking people
- Las VegasLas Vegas, United StatesTaking people
- LawrencevilleLawrenceville, United StatesTaking people
- LaytonLayton, United StatesTaking people
- LeesburgLeesburg, United StatesTaking people
- LexingtonLexington, United StatesTaking people
- LimaLima, United StatesTaking people
- LinwoodLinwood, United StatesTaking people
- Little RockLittle Rock, United StatesTaking people
- Long BeachLong Beach, United StatesTaking people
- LynwoodLynwood, United StatesTaking people
- MaconMacon, United StatesTaking people
- ManassasManassas, United StatesTaking people
- MaumeeMaumee, United StatesTaking people
- McAllenMcAllen, United StatesTaking people
- McKinneyMcKinney, United StatesTaking people
- MediaMedia, United StatesTaking people
- MelbourneMelbourne, United StatesTaking people
- MesaMesa, United StatesTaking people
- MesquiteMesquite, United StatesTaking people
- MetairieMetairie, United StatesTaking people
- MiamiMiami, United StatesTaking people
- MidlandMidland, United StatesTaking people
- Missouri CityMissouri City, United StatesTaking people
- MonroeMonroe, United StatesTaking people
- MooreMoore, United StatesTaking people
- MoraineMoraine, United StatesTaking people
- New OrleansNew Orleans, United StatesTaking people
- New WindsorNew Windsor, United StatesTaking people
- NewhallNewhall, United StatesTaking people
- Newport NewsNewport News, United StatesTaking people
- NorfolkNorfolk, United StatesTaking people
- NormanNorman, United StatesTaking people
- North MassapequaNorth Massapequa, United StatesTaking people
- NorthridgeNorthridge, United StatesTaking people
- Oak BrookOak Brook, United StatesTaking people
- Oklahoma CityOklahoma City, United StatesTaking people
- Olive BranchOlive Branch, United StatesTaking people
- OmahaOmaha, United StatesTaking people
- OpelousasOpelousas, United StatesTaking people
- Orland ParkOrland Park, United StatesTaking people
- OrlandoOrlando, United StatesTaking people
- Palm SpringsPalm Springs, United StatesTaking people
- ParisParis, United StatesTaking people
- PasadenaPasadena, United StatesTaking people
- PeoriaPeoria, United StatesTaking people
- PetoskeyPetoskey, United StatesTaking people
- PhiladelphiaPhiladelphia, United StatesTaking people
- PhoenixPhoenix, United StatesTaking people
- PlanoPlano, United StatesTaking people
- Port ArthurPort Arthur, United StatesTaking people
- Port GibsonPort Gibson, United StatesTaking people
- PortsmouthPortsmouth, United StatesTaking people
- PoughkeepsiePoughkeepsie, United StatesTaking people
- RichfieldRichfield, United StatesTaking people
- RichmondRichmond, United StatesTaking people
- RidgelandRidgeland, United StatesTaking people
- RiverheadRiverhead, United StatesTaking people
- RockvilleRockville, United StatesTaking people
- RosedaleRosedale, United StatesTaking people
- Saint CloudSaint Cloud, United StatesTaking people
- Saint PaulSaint Paul, United StatesTaking people
- Salt Lake CitySalt Lake City, United StatesTaking people
- San AntonioSan Antonio, United StatesTaking people
- San DiegoSan Diego, United StatesTaking people
- San DimasSan Dimas, United StatesTaking people
- San RamonSan Ramon, United StatesTaking people
- Saratoga SpringsSaratoga Springs, United StatesTaking people
- SheffieldSheffield, United StatesTaking people
- ShelbyShelby, United StatesTaking people
- ShermanSherman, United StatesTaking people
- ShreveportShreveport, United StatesTaking people
- Sioux FallsSioux Falls, United StatesTaking people
- SlidellSlidell, United StatesTaking people
- South BendSouth Bend, United StatesTaking people
- SouthfieldSouthfield, United StatesTaking people
- SpringfieldSpringfield, United StatesTaking people
- St LouisSt Louis, United StatesTaking people
- StatesvilleStatesville, United StatesTaking people
- StocktonStockton, United StatesTaking people
- StonecrestStonecrest, United StatesTaking people
- Stony BrookStony Brook, United StatesTaking people
- SuffolkSuffolk, United StatesTaking people
- Sugar LandSugar Land, United StatesTaking people
- Sun CitySun City, United StatesTaking people
- Sun City WestSun City West, United StatesTaking people
- SuwaneeSuwanee, United StatesTaking people
- TampaTampa, United StatesTaking people
- TarzanaTarzana, United StatesTaking people
- TempeTempe, United StatesTaking people
- The BronxThe Bronx, United StatesTaking people
- ThomasvilleThomasville, United StatesTaking people
- Tinley ParkTinley Park, United StatesTaking people
- Toluca LakeToluca Lake, United StatesTaking people
- TomballTomball, United StatesTaking people
- TopekaTopeka, United StatesTaking people
- TorranceTorrance, United StatesTaking people
- TroyTroy, United StatesTaking people
- TucsonTucson, United StatesTaking people
- TupeloTupelo, United StatesTaking people
- TustinTustin, United StatesTaking people
- UniontownUniontown, United StatesTaking people
- ValparaisoValparaiso, United StatesTaking people
- VersaillesVersailles, United StatesTaking people
- VistaVista, United StatesTaking people
- WacoWaco, United StatesTaking people
- Walnut CreekWalnut Creek, United StatesTaking people
- WaterburyWaterbury, United StatesTaking people
- WellingtonWellington, United StatesTaking people
- West SenecaWest Seneca, United StatesTaking people
- WestfieldWestfield, United StatesTaking people
- Wheat RidgeWheat Ridge, United StatesTaking people
- WhitelandWhiteland, United StatesTaking people
- WichitaWichita, United StatesTaking people
- WinchesterWinchester, United StatesTaking people
- Winston-SalemWinston-Salem, United StatesTaking people
- Winter ParkWinter Park, United StatesTaking people
- YumaYuma, United StatesTaking people
- ZacharyZachary, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Alnylam Pharmaceuticals
- Trial code
- NCT07181109EU 2025-522960-34-00
- Record updated
- 15 October 2026
- Original description
The purpose of this study is to evaluate whether zilebesiran versus placebo reduces the risk of cardiovascular (CV) death, nonfatal myocardial infarction (MI), nonfatal stroke, or heart failure (HF) events. This is an event-driven study that will continue until the targeted number of positively adjudicated primary endpoint clinical outcome events (COEs) have been reached.Read full original descriptionShow less
ZENITH: A Phase 3 Global, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Zilebesiran in Addition to Standard of Care in Reducing Major Adverse Cardiovascular Events in Adult Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease
The purpose of this study is to evaluate whether zilebesiran versus placebo reduces the risk of cardiovascular (CV) death, nonfatal myocardial infarction (MI), nonfatal stroke, or heart failure (HF) events. This is an event-driven study that will continue until the targeted number of positively adjudicated primary endpoint clinical outcome events (COEs) have been reached.
Inclusion: Is 18 years or older for patients with established cardiovascular disease (CVD); Is 55 years or older for patients with high risk for CVD; Has established CVD (defined as coronary, cerebrovascular, or peripheral artery disease) or high risk for CVD; Has treated hypertension on stable therapy with at least 2 standard of care antihypertensive medications, one of which must be a thiazide, thiazide-like, or loop diuretic.
Exclusion: Has known history of secondary hypertension; Has alanine aminotransferase (ALT) or aspartate aminotransferase (AST) >3×upper limit of normal (ULN); Has total serum bilirubin >1.5×ULN; Has international normalized ratio (INR) >1.5; Has serum potassium >4.8 mEq/L; Has estimated glomerular filtration rate (eGFR) <30 mL/min/1.73m\^2; Has symptomatic orthostatic hypotension.