Testing time-restricted eating to help keep weight off after weight loss
Tests a daily eating-window plan in adults aged 25 to 65 who recently lost weight.
Plain-language title generated from the registry record
Registry title: Time Restricted Eating for WeIght LoSs MainTenance-2
Key facts
- Where
- New York, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 25 and 65 years old?
Source: NCT07190170, who can take part
Where in United States
- NYU Langone HealthNew York, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- NYU Langone Health
- Trial code
- NCT07190170
- Record updated
- 2 November 2026
- Original description
The TWIST 2.0 Study is a 12-month, 2-arm RCT in adults with recent weight loss. We will examine the efficacy of TRE on weight (Aim 1a) and fat mass (Aim 1b) regain, and describe changes in subjective appetite following a mixed-meal tolerance test (Exploratory).Read full original descriptionShow less
Time Restricted Eating for WeIght LoSs MainTenance-2 (TWIST-2): A Single-site, 2-arm Randomized Clinical Trial in Adults With Recent Weight Loss
The TWIST 2.0 Study is a 12-month, 2-arm RCT in adults with recent weight loss. We will examine the efficacy of TRE on weight (Aim 1a) and fat mass (Aim 1b) regain, and describe changes in subjective appetite following a mixed-meal tolerance test (Exploratory).
Inclusion: ≥5% non-surgical weight loss in the last 3 mos; current BMI 20.5-45 mg/kg2; between the ages 25 to 65 years old; own a smartphone or willing to use a smartphone if provided for self-monitoring. For in-person screening, eligible participants will provide signed informed consent and have their temporal eating patterns measured.
Exclusion: previous or planned bariatric surgery; previous or current history of eating disorder; currently on appetite suppressants; taking medications that affect body weight or would preclude TRE; unable to participate meaningfully in the intervention (e.g., uncorrected sight and hearing impairment); have type 1 or type 2 diabetes, or other conditions that would preclude restricted eating windows; pregnant, trying to get pregnant or breastfeeding; ongoing participation in another weight-management research study; continued participation in a weight loss program other than the proposed study; currently following intermittent fasting; or skipping meals; eating window <11h 59min/day; perform overnight shift work more than once a week; work that includes travel across one or more time zones; unable or unwilling to provide informed consent; unwilling to accept randomization assignment; unable to log at least 2 meals into the smartphone app for 70% (~20 days) during of the run-in period; narcolepsy,; >2.5 kg additional weight loss during run-in phase (weight regain is not an exclusion criteria); is non-English speaking (the mCC app is currently only available in English).