Testing lunsekimig against placebo in adults with eosinophilic COPD
Tests lunsekimig injections against placebo in adults with chronic obstructive pulmonary disease.
Plain-language title generated from the registry record
Registry title: Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD) Characterized by an Eosinophilic Phenotype
Key facts
- Where
- Allen, Anderson, Ann Arbor, Beaumont, Bellaire, Boerne, Boston, Boynton Beach, Carrollton, Chandler, Chicago, Chicago Ridge, Chickasha, Cordele, Corsicana, Cutler Bay, Cypress, Dallas, Dayton, DeSoto, Doral, Durham, East Orange, Evanston, Fargo, Fayetteville, Flushing, Fort Myers, Harlingen, Henderson, Hickory, Houston, Indianapolis, Kansas City, Kingwood, La Palma, Lady Lake, Lampasas, Lancaster, Long Beach, Los Angeles, Madison Heights, Miami, Miami Lakes, Morrisville, Nashville, Newport Beach, Orlando, Palm Beach Gardens, Pembroke Pines, Philadelphia, Phoenix, Pittsburgh, Portland, Redding, Rochester, San Antonio, Sioux Falls, Surprise, Tampa, Valencia, Williamsburg, Winston-Salem, and Zachary, United StatesSee the 75 sites
- Phase
- Phase 3
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 80 years old?
Source: NCT07190209, who can take part
Where in United States
- Wellness Clinical Research - Allen- Site Number : 8400085Allen, United StatesTaking people
- AnMed Oglesby Center- Site Number : 8400074Anderson, United StatesTaking people
- University of Michigan Health System - Ann Arbor- Site Number : 8400090Ann Arbor, United StatesTaking people
- REX Clinical Trials - Beaumont- Site Number : 8400014Beaumont, United StatesTaking people
- Novel Research - Bellaire- Site Number : 8400116Bellaire, United StatesTaking people
- South Texas Medical Research Institute - TTS Research- Site Number : 8400018Boerne, United StatesTaking people
- Brigham & Women's Hospital- Site Number : 8400148Boston, United StatesTaking people
- Boynton BeachBoynton Beach, United StatesTaking people
- TEN20 Clinical Research - Carrollton- Site Number : 8400141Carrollton, United StatesTaking people
- ChandlerChandler, United StatesTaking people
- University of Illinois-Chicago - College of Medicine- Site Number : 8400055Chicago, United StatesTaking people
- Chicago RidgeChicago Ridge, United StatesTaking people
- Epic Medical Research - Chickasha- Site Number : 8400097Chickasha, United StatesTaking people
- Private Practice - Dr. David Kavtaradze- Site Number : 8400006Cordele, United StatesTaking people
- Corsicana Medical Research- Site Number : 8400134Corsicana, United StatesTaking people
- Beautiful Minds Clinical Research Center- Site Number : 8400017Cutler Bay, United StatesTaking people
- Syri Research Center- Site Number : 8400069Cypress, United StatesTaking people
- Texas Health Presbyterian Hospital Dallas- Site Number : 8400032Dallas, United StatesTaking people
- DaytonDayton, United StatesTaking people
- Epic Medical Research - De Soto- Site Number : 8400095DeSoto, United StatesTaking people
- DoralDoral, United StatesNo longer taking part
- Duke Asthma, Allergy and Airway Center- Site Number : 8400047Durham, United StatesTaking people
- Sanmora Bespoke Clinical Research Solutions- Site Number : 8400144East Orange, United StatesTaking people
- NorthShore Medical Group - Evanston (Endeavor Health)- Site Number : 8400073Evanston, United StatesTaking people
- Plains Clinical Research Center- Site Number : 8400140Fargo, United StatesTaking people
- FayettevilleFayetteville, United StatesTaking people
- New York Hospital Queens- Site Number : 8400058Flushing, United StatesTaking people
- Eastern Medical Group Research- Site Number : 8400020Fort Myers, United StatesTaking people
- Valley Institute of Research- Site Number : 8400118Harlingen, United StatesTaking people
- HendersonHenderson, United StatesTaking people
- Advanced Respiratory and Sleep Medicine - Hickory- Site Number : 8400013Hickory, United StatesTaking people
- HoustonHouston, United StatesTaking people
- Baylor College of Medicine- Site Number : 8400076Houston, United StatesTaking people
- Gulf Coast Clinical Research - Houston- Site Number : 8400049Houston, United StatesTaking people
- HDH Research, Inc.- Site Number : 8400104Houston, United StatesTaking people
- IndianapolisIndianapolis, United StatesTaking people
- University of Kansas Medical Center- Site Number : 8400054Kansas City, United StatesTaking people
- Lumi Research - Kingwood- Site Number : 8400120Kingwood, United StatesTaking people
- Syri Research Center- Site Number : 8400136Kingwood, United StatesTaking people
- La PalmaLa Palma, United StatesTaking people
- Premier Medical Associates- Site Number : 8400012Lady Lake, United StatesNo longer taking part
- Radiance Clinical Research - Lampasas - West Avenue East- Site Number : 8400063Lampasas, United StatesTaking people
- MD First Research - Lancaster- Site Number : 8400102Lancaster, United StatesTaking people
- Long Beach Research Institute- Site Number : 8400027Long Beach, United StatesTaking people
- Downtown L.A. Research Center- Site Number : 8400009Los Angeles, United StatesTaking people
- Madison HeightsMadison Heights, United StatesTaking people
- MiamiMiami, United StatesTaking people
- My Community Research Center- Site Number : 8400164Miami, United StatesTaking people
- Nuren Medical & Research Center- Site Number : 8400030Miami, United StatesTaking people
- Reed Medical Research Corp- Site Number : 8400167Miami, United StatesTaking people
- University of Miami Dermatology Clinical Trials Unit- Site Number : 8400078Miami, United StatesTaking people
- Deluxe Health Center- Site Number : 8400010Miami Lakes, United StatesTaking people
- Science 37, Llc- Site Number : 8400154Morrisville, United StatesTaking people
- Meharry Medical College- Site Number : 8400133Nashville, United StatesTaking people
- Newport BeachNewport Beach, United StatesTaking people
- Omega Research Consultants - Orlando - Forest City- Site Number : 8400015Orlando, United StatesTaking people
- Pharmakon Medical Research- Site Number : 8400156Palm Beach Gardens, United StatesTaking people
- Broward Research Center - Pembroke Pines- Site Number : 8400053Pembroke Pines, United StatesTaking people
- Temple University Hospital- Site Number : 8400059Philadelphia, United StatesTaking people
- Pulmonary Associates - Phoenix - East Bell Road- Site Number : 8400114Phoenix, United StatesTaking people
- Preferred Primary Care Physicians - Pleasant Hills- Site Number : 8400092Pittsburgh, United StatesTaking people
- Oregon Health & Science University (OHSU)- Site Number : 8400155Portland, United StatesTaking people
- Paradigm Research - Redding- Site Number : 8400108Redding, United StatesTaking people
- Mayo Clinic in Rochester - Minnesota- Site Number : 8400005Rochester, United StatesTaking people
- San AntonioSan Antonio, United StatesTaking people
- Bandera Family Health Care - San Antonio- Site Number : 8400021San Antonio, United StatesTaking people
- Discovery Clinical Trials - San Antonio- Site Number : 8400031San Antonio, United StatesTaking people
- Sioux FallsSioux Falls, United StatesTaking people
- Epic Medical Research - Surprise- Site Number : 8400096Surprise, United StatesTaking people
- Clinical Research Trials of Florida- Site Number : 8400011Tampa, United StatesTaking people
- Deluxe Health Center-Tampa- Site Number : 8400056Tampa, United StatesTaking people
- Amicis Research Center - Valencia- Site Number : 8400119Valencia, United StatesTaking people
- Tidewater Physicians Multispecialty Group Clinical Research - Williamsburg- Site Number : 8400081Williamsburg, United StatesTaking people
- Atrium Health Wake Forest Baptist Pulmonary, Sleep And Allergy- Site Number : 8400048Winston-Salem, United StatesTaking people
- Southern Clinical Research - Zachary- Site Number : 8400113Zachary, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Sanofi
- Trial code
- NCT07190209EU 2024-518016-39-00
- Record updated
- 19 October 2026
- Original description
This is a parallel, Phase 2b/Phase 3, 3-arm study to investigate the efficacy, safety, and tolerability of subcutaneous (SC) treatment with lunsekimig compared with placebo in adult participants (aged 40 to 80 years, inclusive) with inadequately controlled Chronic obstructive pulmonary disease (COPD) characterized by an eosinophilic phenotype.Read full original descriptionShow less
A Phase 2b/Phase 3, Randomized, Double-blind, Placebocontrolled, Multicenter Study, to Investigate the Efficacy and Safety of Lunsekimig in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD) Characterized by an Eosinophilic Phenotype
This is a parallel, Phase 2b/Phase 3, 3-arm study to investigate the efficacy, safety, and tolerability of subcutaneous (SC) treatment with lunsekimig compared with placebo in adult participants (aged 40 to 80 years, inclusive) with inadequately controlled Chronic obstructive pulmonary disease (COPD) characterized by an eosinophilic phenotype.
Participation to the study consists of 3 periods:
* Screening period of up to 4 weeks * Randomized intervention period of approximately 48 weeks * Follow-up period: Approximately 8 weeks The study duration will be up to 60 weeks.
Inclusion: Between 40 to 80 years of age; Physician diagnosed chronic obstructive pulmonary disease (COPD) ≥1 year; Post-bronchodilator forced expiratory volume in 1 second (post-BD FEV1) ≥ 20% and ≤ 70% of predicted value and FEV1/FVC (forced expiratory volume in 1 second /forced vital capacity) <0.70; Former or current smokers ≥10 pack-years; Chronic Airways Assessment Test (CAAT) ≥10; ≥2 moderate or ≥1 severe COPD exacerbations in the prior year; Triple (ICS+LABA+LAMA) COPD therapy ≥12 consecutive weeks; EOS (blood eosinophil count) ≥ 150 cells/μL; 18.0 ≤ Body Mass Index ≤ 40.0 kg/m2.
Exclusion: Long-term oxygen therapy >4.0 L/min or requirement of >2.0 L/min to maintain oxygen saturation >88% at rest; Concomitant therapies:; long-term macrolides or phosphodiesterase Type 3 (PDE-3) or PDE-4 inhibitors unless on stable therapy for >6 months; any biologic therapy or systemic immunosuppressant within 4 months or 5 half-lives prior to Screening; The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial; Asthma, including pediatric asthma, or asthma-COPD overlap syndrome (ACOS); Significant pulmonary disease other than COPD; Unstable disorder that can impact participants safety or study outcomes; Active or incompletely treated tuberculosis; Current or past malignancies; Participants are excluded from the study if any of the following criteria apply:.