Testing Bevacizumab Added to Chemotherapy and Immunotherapy for Endometrial Cancer
Tests adding bevacizumab to chemotherapy and pembrolizumab in adults with advanced or recurrent endometrial cancer.
Plain-language title generated from the registry record
Registry title: Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer
Key facts
- Where
- ‘Aiea, ‘Ewa Beach, Albuquerque, Anaconda, Anchorage, Ankeny, Ann Arbor, Ashland, Athens, Atlanta, Augusta, Aurora, Baltimore, Basking Ridge, Battle Creek, Bay Shore, Beachwood, Bellevue, Billings, Birmingham, Boston, Bozeman, Brainerd, Brewer, Bridgeport, Brighton, Burlington, Camden, Canton, Carmichael, Carroll, Cedar Rapids, Chapel Hill, Chardon, Charleston, Charlottesville, Chelsea, Chicago, Cleveland, Clinton, Clive, Coeur d'Alene, Colorado Springs, Columbia, Columbus, Commack, Coon Rapids, Crown Point, Danville, Decatur, Deer River, DeKalb, Delaware, Des Moines, Detroit, Dublin, Duluth, Durham, Edina, Edmonds, Effingham, Elk Grove, Erie, Escanaba, Evanston, Fargo, Farmington Hills, Fayetteville, Flint, Flushing, Fort Collins, Fort Dodge, Franklin, Fremont, Fresno, Geneva, Glenview, Goldsboro, Goshen, Grand Rapids, Great Falls, Greeley, Green Bay, Greenlawn, Greensburg, Harrison, Hartford, Harvey, Hershey, Hibbing, Highland Park, Highlands Ranch, Honolulu, Indianapolis, Iowa City, Issaquah, Jacksonville, Kalamazoo, Kalispell, Kearney, La Crosse, Lake Success, Lansing, Las Vegas, Lexington, Little Rock, Livingston, Livonia, Los Angeles, Loveland, Manchester, Manistique, Mansfield, Marion, Marrero, Martinsburg, Mattoon, Mechanicsburg, Mentor, Metairie, Middletown, Millville, Milwaukee, Minneapolis, Missoula, Modesto, Montvale, Morgantown, Muskegon, N. Venice, Nashville, New Britain, New Brunswick, New Lenox, New Orleans, New York, Newark, Niles, Normal, Norton Shores, O'Fallon, Oak Brook, Oak Park, Oakland, Oconto Falls, Oklahoma City, Omaha, Orland Park, Palo Alto, Paramus, Parkersburg, Parma, Peabody, Peoria, Philadelphia, Phoenix, Pickerington, Pittsburgh, Pontiac, Portland, Post Falls, Providence, Raleigh, Rancho Mirage, Reed City, Rego Park, Rehoboth Beach, Richmond, Ridgewood, Rochester, Rocklin, Rogers, Roseville, Sacramento, Saint Joseph, Saint Louis Park, Saint Paul, Salt Lake City, San Francisco, San Jose, San Leandro, San Rafael, Sandpoint, Sandstone, Santa Clara, Santa Rosa, Sarasota, Scarborough, Seattle, Sewell, Sheboygan, Sleepy Hollow, South Bend, South Jordan, South San Francisco, Spooner, Springdale, Springfield, St Louis, Staten Island, Stony Brook, Sturgeon Bay, Superior, Sylvania, Syracuse, The Bronx, Traverse City, Tualatin, Tucson, Uniondale, Urbana, Vallejo, Vancouver, Venice, Virginia, Walnut Creek, Warrenville, Washington, Washington D.C., Waukee, Webster, Westerville, Westlake, Willow Grove, Woodbury, Woodland, Wyoming, and Ypsilanti, United StatesSee the 309 sites
- Phase
- Phase 3
Where in United States
- Pali Momi Medical Center‘Aiea, United StatesTaking people
- Queen's Cancer Center - Pearlridge‘Aiea, United StatesTaking people
- The Queen's Medical Center - West Oahu‘Ewa Beach, United StatesTaking people
- University of New Mexico Cancer CenterAlbuquerque, United StatesTaking people
- Community Hospital of AnacondaAnaconda, United StatesTaking people
- Alaska Women's Cancer CareAnchorage, United StatesTaking people
- UI Health Care Mission Cancer and Blood - Ankeny ClinicAnkeny, United StatesTaking people
- University of Michigan Rogel Cancer CenterAnn Arbor, United StatesTaking people
- Duluth Clinic AshlandAshland, United StatesTaking people
- OhioHealth O'Bleness HospitalAthens, United StatesTaking people
- Emory University Hospital MidtownAtlanta, United StatesTaking people
- Emory University Hospital/Winship Cancer InstituteAtlanta, United StatesTaking people
- Grady Health SystemAtlanta, United StatesTaking people
- Augusta University Medical CenterAugusta, United StatesTaking people
- UCHealth University of Colorado HospitalAurora, United StatesTaking people
- Johns Hopkins University/Sidney Kimmel Cancer CenterBaltimore, United StatesTaking people
- MedStar Franklin Square Medical Center/Weinberg Cancer InstituteBaltimore, United StatesTaking people
- Memorial Sloan Kettering Basking RidgeBasking Ridge, United StatesTaking people
- Bronson Battle CreekBattle Creek, United StatesTaking people
- Northwell Health Imbert Cancer CenterBay Shore, United StatesTaking people
- UHHS-Chagrin Highlands Medical CenterBeachwood, United StatesTaking people
- Nebraska Medicine-BellevueBellevue, United StatesTaking people
- Billings Clinic Cancer CenterBillings, United StatesTaking people
- Intermountain Health West End ClinicBillings, United StatesTaking people
- Saint Vincent Frontier Cancer CenterBillings, United StatesTaking people
- University of Alabama at Birmingham Cancer CenterBirmingham, United StatesTaking people
- Dana-Farber Cancer InstituteBoston, United StatesTaking people
- Bozeman Health Deaconess HospitalBozeman, United StatesTaking people
- Essentia Health Saint Joseph's Medical CenterBrainerd, United StatesTaking people
- Lafayette Family Cancer Center-EMMCBrewer, United StatesTaking people
- United Hospital CenterBridgeport, United StatesTaking people
- Trinity Health IHA Medical Group Hematology Oncology - BrightonBrighton, United StatesTaking people
- University of Michigan - Brighton Center for Specialty CareBrighton, United StatesTaking people
- Lahey ClinicBurlington, United StatesTaking people
- Cooper Hospital University Medical CenterCamden, United StatesTaking people
- Aultman Health FoundationCanton, United StatesTaking people
- Trinity Health IHA Medical Group Hematology Oncology - CantonCanton, United StatesTaking people
- Mercy Cancer Center - CarmichaelCarmichael, United StatesTaking people
- Mercy San Juan Medical CenterCarmichael, United StatesTaking people
- Saint Anthony Regional HospitalCarroll, United StatesTaking people
- Mercy HospitalCedar Rapids, United StatesTaking people
- Oncology Associates at Mercy Medical CenterCedar Rapids, United StatesTaking people
- UNC Lineberger Comprehensive Cancer CenterChapel Hill, United StatesTaking people
- Geauga HospitalChardon, United StatesTaking people
- Vandalia Health/CAMC Institute for Academic MedicineCharleston, United StatesTaking people
- University of Virginia Cancer CenterCharlottesville, United StatesTaking people
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea HospitalChelsea, United StatesTaking people
- Northwestern UniversityChicago, United StatesTaking people
- Rush MD Anderson Cancer CenterChicago, United StatesTaking people
- University of Chicago Comprehensive Cancer CenterChicago, United StatesTaking people
- Case Western Reserve UniversityCleveland, United StatesTaking people
- Southeastern Medical Oncology Center-ClintonClinton, United StatesTaking people
- UI Health Care Mission Cancer and Blood - West Des Moines ClinicClive, United StatesTaking people
- Kootenai Health - Coeur d'AleneCoeur d'Alene, United StatesTaking people
- Memorial Hospital NorthColorado Springs, United StatesTaking people
- UCHealth Memorial Hospital CentralColorado Springs, United StatesTaking people
- MU Health - University Hospital/Ellis Fischel Cancer CenterColumbia, United StatesTaking people
- Columbus Oncology and Hematology Associates IncColumbus, United StatesTaking people
- Doctors HospitalColumbus, United StatesTaking people
- Grant Medical CenterColumbus, United StatesTaking people
- Ohio State University Comprehensive Cancer CenterColumbus, United StatesTaking people
- Riverside Methodist HospitalColumbus, United StatesTaking people
- Memorial Sloan Kettering CommackCommack, United StatesTaking people
- Mercy HospitalCoon Rapids, United StatesTaking people
- UChicago Medicine Northwest IndianaCrown Point, United StatesTaking people
- Carle at The RiverfrontDanville, United StatesTaking people
- Cancer Care Specialists of Illinois - DecaturDecatur, United StatesTaking people
- Decatur Memorial HospitalDecatur, United StatesTaking people
- Emory Decatur HospitalDecatur, United StatesTaking people
- Essentia Health - Deer River ClinicDeer River, United StatesTaking people
- Northwestern Medicine Cancer Center KishwaukeeDeKalb, United StatesTaking people
- Delaware Health Center-Grady Cancer CenterDelaware, United StatesTaking people
- Grady Memorial HospitalDelaware, United StatesTaking people
- Broadlawns Medical CenterDes Moines, United StatesTaking people
- Iowa Methodist Medical CenterDes Moines, United StatesTaking people
- Mercy Medical Center - Des MoinesDes Moines, United StatesTaking people
- UI Health Care Mission Cancer and Blood - Des Moines ClinicDes Moines, United StatesTaking people
- UI Health Care Mission Cancer and Blood - Laurel ClinicDes Moines, United StatesTaking people
- Wayne State University/Karmanos Cancer InstituteDetroit, United StatesTaking people
- Columbus Oncology and Hematology AssociatesDublin, United StatesTaking people
- Dublin Methodist HospitalDublin, United StatesTaking people
- Kaiser Permanente DublinDublin, United StatesTaking people
- Essentia Health Cancer CenterDuluth, United StatesTaking people
- Duke University Medical CenterDurham, United StatesTaking people
- Fairview Southdale HospitalEdina, United StatesTaking people
- Minnesota Oncology - EdinaEdina, United StatesTaking people
- Swedish Cancer Institute-EdmondsEdmonds, United StatesTaking people
- Carle Physician Group-EffinghamEffingham, United StatesTaking people
- Mercy Cancer Center - Elk GroveElk Grove, United StatesTaking people
- UPMC Hillman Cancer Center ErieErie, United StatesTaking people
- OSF Saint Francis Hospital and Medical GroupEscanaba, United StatesTaking people
- NorthShore University HealthSystem-Evanston HospitalEvanston, United StatesTaking people
- Essentia Health Cancer Center-South University ClinicFargo, United StatesTaking people
- Weisberg Cancer Treatment CenterFarmington Hills, United StatesTaking people
- Highlands Oncology Group - FayettevilleFayetteville, United StatesTaking people
- Cancer Hematology Centers - FlintFlint, United StatesTaking people
- Genesys Hurley Cancer InstituteFlint, United StatesTaking people
- Hurley Medical CenterFlint, United StatesTaking people
- Northwell Health Physician Partners at FlushingFlushing, United StatesTaking people
- Cancer Care and Hematology-Fort CollinsFort Collins, United StatesTaking people
- Poudre Valley HospitalFort Collins, United StatesTaking people
- UI Healthcare Mission Cancer and Blood - Fort DodgeFort Dodge, United StatesTaking people
- Vanderbilt-Ingram Cancer Center Cool SpringsFranklin, United StatesTaking people
- Kaiser Permanente-FremontFremont, United StatesTaking people
- Kaiser Permanente Fresno Orchard PlazaFresno, United StatesTaking people
- Northwestern Medicine Cancer Center DelnorGeneva, United StatesTaking people
- NorthShore University HealthSystem-Glenbrook HospitalGlenview, United StatesTaking people
- Southeastern Medical Oncology Center-GoldsboroGoldsboro, United StatesTaking people
- Goshen Center for Cancer CareGoshen, United StatesTaking people
- Corewell Health Grand Rapids Hospitals - Butterworth HospitalGrand Rapids, United StatesTaking people
- Trinity Health Grand Rapids HospitalGrand Rapids, United StatesTaking people
- Benefis Sletten Cancer InstituteGreat Falls, United StatesTaking people
- UCHealth Greeley HospitalGreeley, United StatesTaking people
- Saint Vincent Hospital Cancer Center at Saint Mary'sGreen Bay, United StatesTaking people
- Saint Vincent Hospital Cancer Center Green BayGreen Bay, United StatesTaking people
- Northwell Health Cancer Institute at HuntingtonGreenlawn, United StatesTaking people
- UPMC Cancer Centers - Arnold Palmer PavilionGreensburg, United StatesTaking people
- Memorial Sloan Kettering WestchesterHarrison, United StatesTaking people
- Hartford HospitalHartford, United StatesTaking people
- Ingalls Memorial HospitalHarvey, United StatesTaking people
- Penn State Milton S. Hershey Medical CenterHershey, United StatesTaking people
- Essentia Health Hibbing ClinicHibbing, United StatesTaking people
- NorthShore University HealthSystem-Highland Park HospitalHighland Park, United StatesTaking people
- UCHealth Highlands Ranch HospitalHighlands Ranch, United StatesTaking people
- Hawaii Cancer Care Inc - Waterfront PlazaHonolulu, United StatesTaking people
- Kaiser Permanente Moanalua Medical CenterHonolulu, United StatesTaking people
- Kapiolani Medical Center for Women and ChildrenHonolulu, United StatesTaking people
- Queen's Cancer Cenrer - POB IHonolulu, United StatesTaking people
- Queen's Cancer Center - KuakiniHonolulu, United StatesTaking people
- Queen's Medical CenterHonolulu, United StatesTaking people
- Ascension Saint Vincent Indianapolis HospitalIndianapolis, United StatesTaking people
- University of Iowa/Holden Comprehensive Cancer CenterIowa City, United StatesTaking people
- Swedish Cancer Institute-IssaquahIssaquah, United StatesTaking people
- Southeastern Medical Oncology Center-JacksonvilleJacksonville, United StatesTaking people
- Beacon Kalamazoo Cancer CenterKalamazoo, United StatesTaking people
- Bronson Methodist HospitalKalamazoo, United StatesTaking people
- West Michigan Cancer CenterKalamazoo, United StatesTaking people
- Logan Health Medical CenterKalispell, United StatesTaking people
- Fred and Pamela Buffett Cancer Center - KearneyKearney, United StatesTaking people
- Gundersen Lutheran Medical CenterLa Crosse, United StatesTaking people
- Northwell Health/Center for Advanced MedicineLake Success, United StatesTaking people
- University of Michigan Health - Sparrow LansingLansing, United StatesTaking people
- Women's Cancer Center of NevadaLas Vegas, United StatesTaking people
- Baptist Health LexingtonLexington, United StatesTaking people
- University of Kentucky/Markey Cancer CenterLexington, United StatesTaking people
- University of Arkansas for Medical SciencesLittle Rock, United StatesTaking people
- Cooperman Barnabas Medical CenterLivingston, United StatesTaking people
- Trinity Health Saint Mary Mercy Livonia HospitalLivonia, United StatesTaking people
- Cedars-Sinai Medical CenterLos Angeles, United StatesTaking people
- Los Angeles General Medical CenterLos Angeles, United StatesTaking people
- USC / Norris Comprehensive Cancer CenterLos Angeles, United StatesTaking people
- Medical Center of the RockiesLoveland, United StatesTaking people
- Hartford HealthCare - ManchesterManchester, United StatesTaking people
- Schoolcraft Memorial HospitalManistique, United StatesTaking people
- OhioHealth Mansfield HospitalMansfield, United StatesTaking people
- OhioHealth Marion General HospitalMarion, United StatesTaking people
- West Jefferson Medical CenterMarrero, United StatesTaking people
- WVUH-Berkely Medical CenterMartinsburg, United StatesTaking people
- Carle Physician Group-Mattoon/CharlestonMattoon, United StatesTaking people
- UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer PavilionMechanicsburg, United StatesTaking people
- UH Seidman Cancer Center at Lake Health Mentor CampusMentor, United StatesTaking people
- East Jefferson General HospitalMetairie, United StatesTaking people
- LSU Healthcare Network / Metairie Multi-Specialty ClinicMetairie, United StatesTaking people
- Memorial Sloan Kettering MonmouthMiddletown, United StatesTaking people
- Beebe South Coastal Health CampusMillville, United StatesTaking people
- Medical College of WisconsinMilwaukee, United StatesTaking people
- Abbott-Northwestern HospitalMinneapolis, United StatesTaking people
- University of Minnesota/Masonic Cancer CenterMinneapolis, United StatesTaking people
- Community Medical CenterMissoula, United StatesTaking people
- Kaiser Permanente- Modesto MOB IIModesto, United StatesTaking people
- Memorial Sloan Kettering BergenMontvale, United StatesTaking people
- West Virginia University HealthcareMorgantown, United StatesTaking people
- Trinity Health Muskegon HospitalMuskegon, United StatesTaking people
- Sarasota Memorial Hospital-VeniceN. Venice, United StatesTaking people
- Vanderbilt Breast Center at One Hundred OaksNashville, United StatesTaking people
- Vanderbilt University/Ingram Cancer CenterNashville, United StatesTaking people
- The Hospital of Central ConnecticutNew Britain, United StatesTaking people
- Rutgers Cancer Institute of New JerseyNew Brunswick, United StatesTaking people
- UC Comprehensive Cancer Center at Silver CrossNew Lenox, United StatesTaking people
- University Medical Center New OrleansNew Orleans, United StatesTaking people
- Lenox Hill HospitalNew York, United StatesTaking people
- Manhattan Eye Ear and Throat HospitalNew York, United StatesTaking people
- Memorial Sloan-Kettering Cancer CenterNew York, United StatesTaking people
- Mount Sinai ChelseaNew York, United StatesTaking people
- Mount Sinai HospitalNew York, United StatesTaking people
- Mount Sinai WestNew York, United StatesTaking people
- Helen F Graham Cancer CenterNewark, United StatesTaking people
- Medical Oncology Hematology Consultants PANewark, United StatesTaking people
- Rutgers New Jersey Medical SchoolNewark, United StatesTaking people
- Corewell Health Lakeland Hospitals - Niles HospitalNiles, United StatesTaking people
- Carle BroMenn Medical CenterNormal, United StatesTaking people
- Carle Cancer Institute NormalNormal, United StatesTaking people
- Cancer and Hematology Centers of Western Michigan - Norton ShoresNorton Shores, United StatesTaking people
- Cancer Care Center of O'FallonO'Fallon, United StatesTaking people
- HSHS Saint Elizabeth's HospitalO'Fallon, United StatesTaking people
- Northwestern Medicine Oak BrookOak Brook, United StatesTaking people
- Rush MD Anderson Cancer Center at Rush Oak ParkOak Park, United StatesTaking people
- Kaiser Permanente-OaklandOakland, United StatesTaking people
- Saint Vincent Hospital Cancer Center at Oconto FallsOconto Falls, United StatesTaking people
- University of Oklahoma Health Sciences CenterOklahoma City, United StatesTaking people
- Nebraska Medicine-Village PointeOmaha, United StatesTaking people
- Nebraska Methodist HospitalOmaha, United StatesTaking people
- University of Nebraska Medical CenterOmaha, United StatesTaking people
- Northwestern Medicine Orland ParkOrland Park, United StatesTaking people
- University of Chicago Medicine-Orland ParkOrland Park, United StatesTaking people
- Stanford Cancer Institute Palo AltoPalo Alto, United StatesTaking people
- The Valley Hospital - Luckow PavilionParamus, United StatesTaking people
- Camden Clark Medical CenterParkersburg, United StatesTaking people
- University Hospitals Parma Medical CenterParma, United StatesTaking people
- Lahey Clinic PeabodyPeabody, United StatesTaking people
- OSF Saint Francis Medical CenterPeoria, United StatesTaking people
- Jefferson Torresdale HospitalPhiladelphia, United StatesTaking people
- Thomas Jefferson University HospitalPhiladelphia, United StatesTaking people
- Cancer Center at Saint Joseph'sPhoenix, United StatesTaking people
- OhioHealth Pickerington Methodist HospitalPickerington, United StatesTaking people
- UPMC-Magee Womens HospitalPittsburgh, United StatesTaking people
- UPMC-Passavant HospitalPittsburgh, United StatesTaking people
- Trinity Health Saint Joseph Mercy Oakland HospitalPontiac, United StatesTaking people
- Legacy Good Samaritan Hospital and Medical CenterPortland, United StatesTaking people
- Providence Portland Medical CenterPortland, United StatesTaking people
- Providence Saint Vincent Medical CenterPortland, United StatesTaking people
- Kootenai Clinic Cancer Services - Post FallsPost Falls, United StatesTaking people
- Rhode Island HospitalProvidence, United StatesTaking people
- Women and Infants HospitalProvidence, United StatesTaking people
- Duke Women's Cancer Care RaleighRaleigh, United StatesTaking people
- Eisenhower Medical CenterRancho Mirage, United StatesTaking people
- Corewell Health Reed City HospitalReed City, United StatesTaking people
- Queens Cancer CenterRego Park, United StatesTaking people
- Beebe Health CampusRehoboth Beach, United StatesTaking people
- VCU Massey Comprehensive Cancer CenterRichmond, United StatesTaking people
- Valley Health System Ridgewood CampusRidgewood, United StatesTaking people
- University of RochesterRochester, United StatesTaking people
- Mercy Cancer Center - RocklinRocklin, United StatesTaking people
- Highlands Oncology Group - RogersRogers, United StatesTaking people
- Kaiser Permanente-RosevilleRoseville, United StatesTaking people
- Kaiser Permanente Downtown CommonsSacramento, United StatesTaking people
- Kaiser Permanente-South SacramentoSacramento, United StatesTaking people
- Mercy Cancer Center - SacramentoSacramento, United StatesTaking people
- University of California Davis Comprehensive Cancer CenterSacramento, United StatesTaking people
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer CenterSaint Joseph, United StatesTaking people
- Corewell Health Lakeland Hospitals - Saint Joseph HospitalSaint Joseph, United StatesTaking people
- Park Nicollet Clinic - Saint Louis ParkSaint Louis Park, United StatesTaking people
- Regions HospitalSaint Paul, United StatesTaking people
- United HospitalSaint Paul, United StatesTaking people
- Huntsman Cancer Institute/University of UtahSalt Lake City, United StatesTaking people
- University of Utah Sugarhouse Health CenterSalt Lake City, United StatesTaking people
- Kaiser Permanente-San FranciscoSan Francisco, United StatesTaking people
- Kaiser Permanente-Santa Teresa-San JoseSan Jose, United StatesTaking people
- Kaiser Permanente San LeandroSan Leandro, United StatesTaking people
- Kaiser San Rafael-GallinasSan Rafael, United StatesTaking people
- Kootenai Clinic Cancer Services - SandpointSandpoint, United StatesTaking people
- Essentia Health SandstoneSandstone, United StatesTaking people
- Kaiser Permanente Medical Center - Santa ClaraSanta Clara, United StatesTaking people
- Kaiser Permanente-Santa RosaSanta Rosa, United StatesTaking people
- Florida Cancer Specialists - Sarasota DowntownSarasota, United StatesTaking people
- FPG - Surgical Oncology Clinics Gynecologic Oncology SurgerySarasota, United StatesTaking people
- Sarasota Memorial Health Care Center at University ParkwaySarasota, United StatesTaking people
- Sarasota Memorial HospitalSarasota, United StatesTaking people
- MaineHealth Maine Medical Center- ScarboroughScarborough, United StatesTaking people
- Fred Hutchinson Cancer CenterSeattle, United StatesTaking people
- Swedish Medical Center-First HillSeattle, United StatesTaking people
- University of Washington Medical Center - MontlakeSeattle, United StatesTaking people
- Sidney Kimmel Cancer Center Washington TownshipSewell, United StatesTaking people
- Saint Vincent Hospital Cancer Center at SheboyganSheboygan, United StatesTaking people
- Sheboygan Physicians GroupSheboygan, United StatesTaking people
- Phelps Memorial Hospital CenterSleepy Hollow, United StatesTaking people
- Memorial Hospital of South BendSouth Bend, United StatesNo longer taking part
- South Jordan Health CenterSouth Jordan, United StatesTaking people
- Kaiser Permanente-South San FranciscoSouth San Francisco, United StatesTaking people
- Essentia Health-Spooner ClinicSpooner, United StatesTaking people
- Highlands Oncology GroupSpringdale, United StatesTaking people
- CoxHealth South HospitalSpringfield, United StatesTaking people
- Mercy Hospital SpringfieldSpringfield, United StatesTaking people
- Southern Illinois University School of MedicineSpringfield, United StatesTaking people
- Springfield ClinicSpringfield, United StatesTaking people
- Springfield Memorial HospitalSpringfield, United StatesTaking people
- Washington University School of MedicineSt Louis, United StatesTaking people
- Staten Island University HospitalStaten Island, United StatesTaking people
- Stony Brook University Medical CenterStony Brook, United StatesTaking people
- Saint Vincent Hospital Cancer Center at Sturgeon BaySturgeon Bay, United StatesTaking people
- Essentia Health Saint Mary's Hospital - SuperiorSuperior, United StatesTaking people
- ProMedica Flower HospitalSylvania, United StatesTaking people
- State University of New York Upstate Medical UniversitySyracuse, United StatesTaking people
- Montefiore Medical Center - Moses CampusThe Bronx, United StatesTaking people
- Montefiore Medical Center-Einstein CampusThe Bronx, United StatesTaking people
- Montefiore Medical Center-Weiler HospitalThe Bronx, United StatesTaking people
- Munson Medical CenterTraverse City, United StatesTaking people
- Legacy Meridian Park HospitalTualatin, United StatesTaking people
- Banner University Medical Center - TucsonTucson, United StatesTaking people
- University of Arizona Cancer Center-North CampusTucson, United StatesTaking people
- Memorial Sloan Kettering NassauUniondale, United StatesTaking people
- Carle Cancer CenterUrbana, United StatesTaking people
- Kaiser Permanente-VallejoVallejo, United StatesTaking people
- Legacy Salmon Creek HospitalVancouver, United StatesTaking people
- Florida Cancer Specialists - Venice PinebrookVenice, United StatesTaking people
- Essentia Health Virginia ClinicVirginia, United StatesTaking people
- Kaiser Permanente-Walnut CreekWalnut Creek, United StatesTaking people
- Northwestern Medicine Cancer Center WarrenvilleWarrenville, United StatesTaking people
- UPMC Cancer Center-WashingtonWashington, United StatesTaking people
- MedStar Washington Hospital CenterWashington D.C., United StatesTaking people
- UI Health Care Mission Cancer and Blood - Waukee ClinicWaukee, United StatesTaking people
- Wilmot Cancer Institute at WebsterWebster, United StatesTaking people
- OhioHealth Westerville Medical Campus/Westerville Cancer CenterWesterville, United StatesTaking people
- UH Seidman Cancer Center at Saint John Medical CenterWestlake, United StatesTaking people
- Asplundh Cancer PavilionWillow Grove, United StatesTaking people
- Minnesota Oncology Hematology PA-WoodburyWoodbury, United StatesTaking people
- Woodland Memorial HospitalWoodland, United StatesTaking people
- University of Michigan Health - WestWyoming, United StatesTaking people
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor CampusYpsilanti, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- National Cancer Institute (NCI)
- Trial code
- NCT07198074
- Record updated
- 6 November 2026
- Original description
This phase III trial compares the effect of bevacizumab in combination with carboplatin, paclitaxel and pembrolizumab to the usual treatments of carboplatin and paclitaxel with or without pembrolizumab in treating patients with stage III, IVA or IVB mismatch repair protein proficient (pMMR) and TP53 mutated endometrial cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) or that has come back after a period of improvement (recurrent). Bevacizumab is in a class of medications called antiangiogenic agents. It works by stopping the formation of blood vessels that bring oxygen and nutrients to tumor. This may slow the growth and spread of tumor. Carboplatin is in a class of medications known as platinum-containing compounds. Carboplatin works by killing, stopping or slowing the growth of tumor cells. Paclitaxel is in a class of medications called antimicrotubule agents. It stops tumor cells from growing and dividing and may kill them. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the tumor, and may interfere with the ability of tumor cells to grow and spread. Adding bevacizumab to the combination of carboplatin, paclitaxel and pembrolizumab may be more effective than the usual treatment combinations of carboplatin and paclitaxel with or without pembrolizumab in treating patients with advanced or recurrent pMMR and TP53 mutated endometrial cancer.Read full original descriptionShow less
A Randomized Phase III Trial of Carboplatin, Paclitaxel, Pembrolizumab Versus Carboplatin, Paclitaxel, Bevacizumab Versus Carboplatin, Paclitaxel, Pembrolizumab, Bevacizumab in the Treatment of pMMR, TP53 Mutated Advanced or Recurrent Endometrial Cancer
This phase III trial compares the effect of bevacizumab in combination with carboplatin, paclitaxel and pembrolizumab to the usual treatments of carboplatin and paclitaxel with or without pembrolizumab in treating patients with stage III, IVA or IVB mismatch repair protein proficient (pMMR) and TP53 mutated endometrial cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) or that has come back after a period of improvement (recurrent). Bevacizumab is in a class of medications called antiangiogenic agents. It works by stopping the formation of blood vessels that bring oxygen and nutrients to tumor. This may slow the growth and spread of tumor. Carboplatin is in a class of medications known as platinum-containing compounds. Carboplatin works by killing, stopping or slowing the growth of tumor cells. Paclitaxel is in a class of medications called antimicrotubule agents. It stops tumor cells from growing and dividing and may kill them. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the tumor, and may interfere with the ability of tumor cells to grow and spread. Adding bevacizumab to the combination of carboplatin, paclitaxel and pembrolizumab may be more effective than the usual treatment combinations of carboplatin and paclitaxel with or without pembrolizumab in treating patients with advanced or recurrent pMMR and TP53 mutated endometrial cancer.
Inclusion: Documentation of disease:; Stage III and stage IVA endometrial cancers (with measurable disease),; Stage IVB endometrial cancer (with or without measurable disease), or; Recurrent endometrial cancer (with or without measurable disease); In patients with measurable disease, lesions will be defined and monitored by RECIST 1.1. Measurable disease (RECIST 1.1) is defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded). Each lesion must be ≥ 10 mm when measured by CT or MRI. Lymph nodes must be ≥ 15 mm in short axis when measured by CT or MRI; Histologic confirmation of the original primary tumor is required (submission of pathology report[s] is required). Patients with the following histologic types are eligible: endometrioid, serous, dedifferentiated/undifferentiated, clear cell, mixed epithelial, carcinosarcoma, adenocarcinoma not otherwise specified (N.O.S.); Patients must have:; Tumoral mismatch repair proficient (pMMR) disease as assessed by immunohistochemistry (IHC) AND; P53 IHC with aberrant staining pattern (aberrant p53 expression is consistent with mutant TP53). TP53 mutation by next-generation sequencing will also be accepted; A pathology report demonstrating results of institutional MMR IHC and p53 IHC and/or TP53 by next-generation sequencing; Patients may have received:; NO prior chemotherapy for treatment of endometrial cancer OR; Prior adjuvant chemotherapy (e.g., paclitaxel/carboplatin alone or as a component of concurrent chemotherapy and radiation therapy [with or without cisplatin]) provided adjuvant chemotherapy was completed ≥ 12 months prior to registration; Patients may have received prior radiation therapy for treatment of endometrial cancer. Prior radiation therapy may have included pelvic radiation therapy, extended field pelvic/para-aortic radiation therapy, intravaginal brachytherapy, and/or palliative radiation therapy. All radiation therapy must be completed at least 4 weeks prior to registration. For patients with recent radiation, they must have RECIST-evaluable disease outside of the radiation field and have recovered their marrow function; Patients may have received prior hormonal (endocrine) therapy. All hormonal (endocrine) therapy must have been completed at least 1 week prior to registration; NO prior pembrolizumab (or other anti-PD1, anti-PDL1 or anti-CTLA4 therapy) or bevacizumab (or other antiangiogenic therapy); Interval or cytoreductive surgery, after start of treatment on this trial, and prior to documentation of disease progression, is NOT permitted; Patients with treated brain metastases are eligible if follow-up brain imaging after central nervous system (CNS)-directed therapy shows no evidence of disease progression. Patients with brain metastases must have follow up imaging demonstrating no evidence of disease progression and that the disease is stable off of steroids; Age ≥ 18; Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 2; Not pregnant and not nursing; Absolute neutrophil count (ANC) ≥ 1,500 cells/mm\^3; Platelets ≥ 100,000 cells/mm\^3; Hemoglobin ≥ 8 g/dl; Creatinine clearance (CrCl) of ≥ 30 mL/min by the Cockcroft-Gault formula; Total bilirubin ≤ 1.5 x institutional upper limit of normal (ULN) (patients with known Gilbert's disease who have bilirubin level ≤ 3 x institutional ULN may be enrolled); Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 3 x institutional ULN; Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class II or better; No active infection requiring parenteral antibiotics; No current evidence of intra-abdominal abscess, abdominal/pelvic fistula (not diverted), gastrointestinal perforation, gastrointestinal (GI) obstruction, and/or need for drainage nasogastric or gastrostomy tube; No clinically significant bleeding within 28 days prior to registration; No uncontrolled hypertension, defined as systolic ≥ 160 mm Hg or diastolic ≥ 100 mm Hg; No major surgery within 28 days of initiation of bevacizumab; No active autoimmune disease or history of autoimmune disease that might recur, which may affect vital organ function or require immune suppressive treatment including corticosteroids. This includes, but is not limited to, patients with a history of immune related neurologic disease, multiple sclerosis, autoimmune (demyelinating) neuropathy, Guillain-Barre syndrome, myasthenia gravis; systemic autoimmune disease such as systemic lupus erythematosus (SLE), connective tissue diseases, scleroderma, inflammatory bowel disease (IBD), Crohn's, ulcerative colitis, hepatitis; and patients with a history of toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome, or phospholipid syndrome because of the risk of recurrence or exacerbation of disease; Patients with vitiligo, endocrine deficiencies including type I diabetes mellitus, thyroiditis managed with replacement hormones including physiologic corticosteroids are eligible; Topical or inhaled steroids are allowed; Patients with rheumatoid arthritis and other arthropathies, Sjogren's syndrome and psoriasis controlled with topical medication and patients with positive serology, such as antinuclear antibodies (ANA), and anti-thyroid antibodies should be evaluated with the presence of target organ involvement and potential need for systemic treatment but should otherwise be eligible; No history of (non-infectious) pneumonitis that required steroids, or current pneumonitis; No history of stem cell or solid organ transplant; No history of allergic reaction to the study agent(s) or compounds of similar chemical or biologic composition to the study agent(s) (or any of its excipients).