Exercise ability in people with transfusion-dependent beta-thalassemia
Compares exercise capacity in adults with transfusion-dependent beta-thalassemia against healthy control subjects.
Plain-language title generated from the registry record
Registry title: Evaluation of Physiological and Psychological Factors Involved in Exercise Intolerance in Patients With β-TTD
Key facts
- Where
- Chambéry, FranceSee the site
Where in France
- CH Métropole-SavoieChambéry, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Centre Hospitalier Metropole Savoie
- Trial code
- NCT07207577
- Record updated
- 7 October 2026
- Original description
The goal of this clinical trial is to compare physical ability of patients with transfusion-dependent β-thalassemia to control subjects. The main question it aims to answer is:Read full original descriptionShow less
Evaluation of Physiological and Psychological Factors Involved in Exercise Intolerance in Patients With Transfusion-dependent β-thalassemia
The goal of this clinical trial is to compare physical ability of patients with transfusion-dependent β-thalassemia to control subjects. The main question it aims to answer is:
is there a difference in power output at first lactate threshold between patients with transfusion-dependent β-thalassemia and control subjects during maximal incremental exercise test.
Participants will have to realise differents exams including measurement of body compposition, maximal incremental exercise test, vertical jump, vasoreactivity test, blood sampling, quality of life questionnaires and neuromuscular assessments.
Inclusion: Patients aged 18 years or older; Patients with transfusion-dependent β-thalassaemia (B0 or B+); Patients who have undergone blood transfusions at intervals of between 1 and 8 weeks for at least 5 years; Have given their free and informed written consent after being informed of the purpose of the study, its conduct and its risks; Be affiliated with a social security scheme; Not participating in any other interventional studies during the duration of this study; Control subjects must meet all of the following criteria to participate in the study:; Subject aged 18 years or older; Matched in age and gender to a βTTD patient included in the study; Declaring to be free of known acute or chronic pathologies; Have given their free written consent after being informed of the purpose of the study, its conduct and its risks; Be affiliated with a social security scheme; Not participate in any other interventional study during the duration of this study; Have 'low' or 'moderate' IPAQ results (inactive or slightly active).
Exclusion: - Having received a bone marrow transplant; Known concomitant medical condition that could affect compliance with the protocol; History of thromboembolic disease; Hospitalised for cardiac decompensation in the last 12 months; Lack of use of limbs (amputee, paraplegic, quadriplegic); Unable to comply with protocol requirements for social, family or other reasons, as determined by the investigator; benefiting of enhanced protection, namely minors, persons deprived of their liberty by judicial or administrative decision, adults under legal protection and, finally, patients in emergency situations; Unable to give consent; Pregnant or breastfeeding women.