Testing home brain stimulation for hard-to-treat depression and major depression
Tests repeated home brain stimulation in adults with depression not helped by usual treatments.
Plain-language title generated from the registry record
Registry title: Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression: A Home-Based Feasibility and Safety Study
Key facts
- Where
- San Diego, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 85 years old?
Source: NCT07217223, who can take part
Where in United States
- UCSD Interventional PsychiatrySan Diego, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of California, San Diego
- Trial code
- NCT07217223
- Record updated
- 15 September 2026
- Original description
The investigators propose a single-arm, open-label study to evaluate the effectiveness, safety, tolerability and feasibility of at-home transcranial direct current stimulation (tDCS) as a treatment for depression, particularly in cases where patients have not responded well to traditional therapies. Treatment will be delivered over a 2-week period with daily weekday treatments i.e., five tDCS sessions, each lasting 20 minutes, spaced by approximately 20-minute inter-session intervals, for a total of three hours a day. Participants will self-administer treatment at home under direct remote supervision. Pre- and post- treatment neurophysiological biomarkers sessions will also be carried out. The study aims to examine changes in mood, brain activity, and related clinical outcomes before, during, and after treatment, with the goal to provide more information that can be used for future studies.Read full original descriptionShow less
Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression: A Home-Based Feasibility and Safety Study
The investigators propose a single-arm, open-label study to evaluate the effectiveness, safety, tolerability and feasibility of at-home transcranial direct current stimulation (tDCS) as a treatment for depression, particularly in cases where patients have not responded well to traditional therapies. Treatment will be delivered over a 2-week period with daily weekday treatments i.e., five tDCS sessions, each lasting 20 minutes, spaced by approximately 20-minute inter-session intervals, for a total of three hours a day. Participants will self-administer treatment at home under direct remote supervision. Pre- and post- treatment neurophysiological biomarkers sessions will also be carried out. The study aims to examine changes in mood, brain activity, and related clinical outcomes before, during, and after treatment, with the goal to provide more information that can be used for future studies.
PLEASE NOTE: THERE WILL BE 4 APPOINTMENTS THAT MUST OCCUR IN PERSON IN SAN DIEGO, CA.
Inclusion: People between the ages of 18 and 85 at the time of screening; Currently diagnosed with Major Depressive Disorder (MDD) as measured by the MINI and a MADRS score of ≥ 20; Safe for TMS as measures by the TMS Adult Safety Screening (TASS); Medical records confirming a history of failing to achieve clinical response to an adequate antidepressant trial as defined an Antidepressant Treatment History Form (ATHF) score ≥ 3 or ) or shown intolerance to at least two inadequate trials (score 1 or 2), without psychiatric illness due to a general medical condition; Stable internet connection and a device compatible with Microsoft Teams.
Exclusion: Contraindication to receiving tDCS (e.g., ferromagnetic implant, history of seizure, known brain lesion); History of psychotic or bipolar disorder or depression with psychotic features; Significant borderline personality disorder; Current moderate or severe substance use disorder or demonstrating signs of acute substance withdrawal; Clinically significant suicidality disorder; History of significant neurologic disease, including dementia, Parkinson's or Huntington's disease, brain tumor, seizure disorder, subdural hematoma, multiple sclerosis, or history of significant head trauma with persistent symptoms; Unstable medical illness; History of TMS (greater than 15 sessions) without a clinically meaningful response.; History of ketamine (greater than 4 sessions) without a clinically meaningful response; dermatological conditions contraindicating tDCS; Pregnancy or lactation, lack of adequate birth control in women of childbearing age; Significant comorbid obsessive-compulsive or post-traumatic stress:; Chronic depression (defined as of over 5 years duration); Require a benzodiazepine with a dose > lorazepam 2 mg/day; Non-correctable sensory impairments; Inability to consent or participate as an outpatient.