Tests nucresiran against vutrisiran in hereditary transthyretin amyloidosis with polyneuropathy
Tests nucresiran, compared with vutrisiran, in adults with hereditary transthyretin amyloidosis nerve damage.
Plain-language title generated from the registry record
Registry title: TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy
Key facts
- Where
- Aurora, Baltimore, Boston, Chapel Hill, Chicago, Dallas, Houston, Nashville, New York, and Rochester, United StatesSee the 10 sites
- Phase
- Phase 3
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 85 years old?
Source: NCT07223203, who can take part
Where in United States
- AuroraAurora, United StatesTaking people
- BaltimoreBaltimore, United StatesTaking people
- BostonBoston, United StatesTaking people
- Chapel HillChapel Hill, United StatesTaking people
- ChicagoChicago, United StatesTaking people
- DallasDallas, United StatesTaking people
- HoustonHouston, United StatesTaking people
- NashvilleNashville, United StatesTaking people
- New YorkNew York, United StatesTaking people
- RochesterRochester, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Alnylam Pharmaceuticals
- Trial code
- NCT07223203EU 2025-522544-40-00
- Record updated
- 8 October 2026
- Original description
The purpose of this study is to:Read full original descriptionShow less
TRITON-PN: A Phase 3, Global, Randomized, Open-Label Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy (hATTR-PN)
The purpose of this study is to:
* Determine the efficacy of nucresiran in patients with hATTR-PN by evaluating the effect on neurologic impairment, quality of life, nutritional status, disability, and gait speed * Demonstrate superiority of nucresiran compared to in-study vutrisiran with respect to serum transthyretin (TTR) levels
Inclusion: Has documented diagnosis of hATTR-PN; Has a diagnosis of hATTR amyloidosis with polyneuropathy with a documented TTR gene variant; Has a neuropathy impairment score (NIS) of 5 to 130 (inclusive); Has a Karnofsky Performance Status (KPS) of ≥60%.
Exclusion: Has had a liver transplant or is likely, in the opinion of the Investigator, to undergo liver transplantation during the Treatment Period of the study; Has a New York Heart Association (NYHA) heart failure classification >2; Has alanine aminotransferase (ALT) or aspartate aminotransferase (AST) >2.5 upper limit of normal (ULN); Has total bilirubin >1.5 ULN; Has estimated glomerular filtration rate (eGFR) ≤30 mL/min/1.73m\^2; Has known other (non-hATTR) forms of amyloidosis or clinical evidence of leptomeningeal amyloidosis; Has other known causes of sensorimotor or autonomic neuropathy.