Tests kisspeptin response in adults with and without long COVID
Compares how people with and without long COVID respond to one kisspeptin dose.
Plain-language title generated from the registry record
Registry title: Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease
Key facts
- Where
- Boston, United StatesSee the site
- Phase
- Phase 1
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 60 years old?
Source: NCT07224490, who can take part
Where in United States
- Massachusetts General HospitalBoston, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Stephanie B. Seminara, MD
- Trial code
- NCT07224490
- Record updated
- 13 July 2026
- Original description
The objective of this protocol is to use a case-control paradigm to compare the response to an intravenous administration of kisspeptin in individuals with and without post-covid-19 syndrome. The study subjects will receive a single bolus of kisspeptin.Read full original descriptionShow less
Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease
The objective of this protocol is to use a case-control paradigm to compare the response to an intravenous administration of kisspeptin in individuals with and without post-covid-19 syndrome. The study subjects will receive a single bolus of kisspeptin.
Inclusion: Female (ages 18-45 years) or Male (ages 18-60 years); No current or recent use of a medication (including hormonal replacement) that, in the opinion of a study investigator, can modulate the reproductive axis or willing to complete an appropriate washout for that particular medication and its method of administration; For women, negative serum hCG pregnancy test; For cases, diagnosis of post-covid-19 syndrome; For controls, history of prior covid infection but no diagnosis of post-covid-19 syndrome.
Exclusion: Active use of illicit drugs (not including marijuana); Surgical or natural menopause; Any condition (medical, mental, or behavioral) that, in the opinion of a study investigator, would likely interfere with participation in/completion of the protocol or the interpretation of results; For women,; Pregnant; Trying to become pregnant during protocol participation; Breast feeding.