Compares one steroid shot with prednisone pills for adults with asthma attacks
Tests a single dexamethasone shot against prednisone pills in adults with asthma attacks.
Plain-language title generated from the registry record
Registry title: Giving Asthmatics Intramuscular Steroids for Preventing Return to the Emergency Department
Key facts
- Where
- The Bronx, United StatesSee the site
- Phase
- Phase 4
Where in United States
- Montefiore Medical CenterThe Bronx, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Montefiore Medical Center
- Trial code
- NCT07228052
- Record updated
- 24 July 2026
- Original description
This study aims to compare the efficacy of a one-time IM dose of dexamethasone versus a 5-day course of prednisone in adult ED patients presenting with asthma exacerbations. This is a randomized, controlled, double-blind, non-inferiority trial conducted at two urban EDs within the Montefiore Health System.Read full original descriptionShow less
Giving Asthmatics Intramuscular Steroids for Preventing Return to the Emergency Department: A Randomized Control Trial
This study aims to compare the efficacy of a one-time IM dose of dexamethasone versus a 5-day course of prednisone in adult ED patients presenting with asthma exacerbations. This is a randomized, controlled, double-blind, non-inferiority trial conducted at two urban EDs within the Montefiore Health System.
Inclusion: Adults ≥18 years old presenting to the ED with an asthma exacerbation; Diagnosed with asthma per International Classification of Diseases, 10th Revision (ICD-10) criteria or by the treating clinician; Discharged from the ED with a primary diagnosis of asthma exacerbation; Initiated systemic corticosteroids during the ED visit; Must be English or Spanish speaking.
Exclusion: Current use of systemic corticosteroids, including Emergency Medical Services (EMS) administration before ED arrival; History of severe adverse reactions to corticosteroids; Heart failure and uncontrolled diabetes (glucose >300mg/dL in the ED); Pregnancy or breastfeeding as prednisone is the preferred treatment for asthma in this population; Inability to provide informed consent.