Tests ivonescimab with chemotherapy against bevacizumab for colorectal cancer
Compares ivonescimab plus chemotherapy with bevacizumab plus chemotherapy in adults with metastatic colorectal cancer.
Plain-language title generated from the registry record
Registry title: Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer
Key facts
- Where
- Akron, Atlanta, Aurora, Baltimore, Beverly Hills, Billings, Boston, Burlington, Camden, Canton, Cerritos, Charleston, Charlottesville, Chicago, Cincinnati, Cleveland, Corona, Dallas, Danvers, Denver, Detroit, Duarte, Edgewood, Elmhurst, Fairfax, Fort Wayne, Fort Worth, Fountain Valley, Germantown, Goodyear, Greenville, Hartford, Hermitage, Hialeah, Highlands Ranch, Houston, Huntington Beach, Indianapolis, Irvine, Lebanon, Lincoln, Lone Tree, Los Angeles, Madison, Mayfield Heights, Miami, Miami Beach, Mineola, Minneapolis, Mobile, Murrieta, New Brunswick, New Haven, New Orleans, New York, Newark, Newnan, Newton, Norwich, O'Fallon, Oakland, Ocala, Oklahoma City, Orange, Orlando, Pasadena, Philadelphia, Pinehurst, Pittsburgh, Plantation, Port Saint Lucie, Providence, Rochester, Roseville, Saint Louis Park, Salt Lake City, San Francisco, Santa Clara, Sellersville, Spartanburg, Spokane, Springfield, St. Petersburg, Stanford, Syracuse, Tacoma, Tamarac, The Bronx, Torrance, Tuscaloosa, Tyler, Upland, Vallejo, West Hollywood, Westwood, and White Plains, United StatesSee the 96 sites
- Phase
- Phase 3
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- How many different drug treatment plans (such as chemotherapy) have you had for cancer that has spread?
- Has a test of your tumour shown a change (mutation) in the KRAS, NRAS or BRAF genes?
- Has a test shown that your tumour is 'MSI-high' or 'dMMR'?
Source: NCT07228832, who can take part
Where in United States
- AkronAkron, United StatesTaking people
- AtlantaAtlanta, United StatesTaking people
- AuroraAurora, United StatesTaking people
- BaltimoreBaltimore, United StatesTaking people
- Beverly HillsBeverly Hills, United StatesTaking people
- BillingsBillings, United StatesTaking people
- BostonBoston, United StatesTaking people
- BurlingtonBurlington, United StatesTaking people
- CamdenCamden, United StatesTaking people
- CantonCanton, United StatesTaking people
- CerritosCerritos, United StatesTaking people
- CharlestonCharleston, United StatesTaking people
- CharlottesvilleCharlottesville, United StatesTaking people
- ChicagoChicago, United StatesTaking people
- CincinnatiCincinnati, United StatesTaking people
- ClevelandCleveland, United StatesTaking people
- CoronaCorona, United StatesTaking people
- DallasDallas, United StatesTaking people
- DanversDanvers, United StatesTaking people
- DenverDenver, United StatesTaking people
- DetroitDetroit, United StatesTaking people
- DuarteDuarte, United StatesTaking people
- EdgewoodEdgewood, United StatesTaking people
- ElmhurstElmhurst, United StatesTaking people
- FairfaxFairfax, United StatesTaking people
- Fort WayneFort Wayne, United StatesTaking people
- Fort WorthFort Worth, United StatesTaking people
- Fountain ValleyFountain Valley, United StatesTaking people
- GermantownGermantown, United StatesTaking people
- GoodyearGoodyear, United StatesTaking people
- GreenvilleGreenville, United StatesTaking people
- HartfordHartford, United StatesTaking people
- HermitageHermitage, United StatesTaking people
- HialeahHialeah, United StatesTaking people
- Highlands RanchHighlands Ranch, United StatesTaking people
- HoustonHouston, United StatesTaking people
- Huntington BeachHuntington Beach, United StatesTaking people
- IndianapolisIndianapolis, United StatesTaking people
- IrvineIrvine, United StatesTaking people
- LebanonLebanon, United StatesTaking people
- LincolnLincoln, United StatesTaking people
- Lone TreeLone Tree, United StatesTaking people
- Los AngelesLos Angeles, United StatesTaking people
- MadisonMadison, United StatesTaking people
- Mayfield HeightsMayfield Heights, United StatesTaking people
- MiamiMiami, United StatesTaking people
- Miami BeachMiami Beach, United StatesTaking people
- MineolaMineola, United StatesTaking people
- MinneapolisMinneapolis, United StatesTaking people
- MobileMobile, United StatesTaking people
- MurrietaMurrieta, United StatesTaking people
- New BrunswickNew Brunswick, United StatesTaking people
- New HavenNew Haven, United StatesTaking people
- New OrleansNew Orleans, United StatesTaking people
- New YorkNew York, United StatesTaking people
- NewarkNewark, United StatesTaking people
- NewnanNewnan, United StatesTaking people
- NewtonNewton, United StatesTaking people
- NorwichNorwich, United StatesTaking people
- O'FallonO'Fallon, United StatesTaking people
- OaklandOakland, United StatesTaking people
- OcalaOcala, United StatesTaking people
- Oklahoma CityOklahoma City, United StatesTaking people
- OrangeOrange, United StatesTaking people
- OrlandoOrlando, United StatesTaking people
- PasadenaPasadena, United StatesTaking people
- PhiladelphiaPhiladelphia, United StatesTaking people
- PinehurstPinehurst, United StatesTaking people
- PittsburghPittsburgh, United StatesTaking people
- PlantationPlantation, United StatesTaking people
- Port Saint LuciePort Saint Lucie, United StatesTaking people
- ProvidenceProvidence, United StatesTaking people
- RochesterRochester, United StatesTaking people
- RosevilleRoseville, United StatesTaking people
- Saint Louis ParkSaint Louis Park, United StatesTaking people
- Salt Lake CitySalt Lake City, United StatesTaking people
- San FranciscoSan Francisco, United StatesTaking people
- Santa ClaraSanta Clara, United StatesTaking people
- SellersvilleSellersville, United StatesTaking people
- SpartanburgSpartanburg, United StatesTaking people
- SpokaneSpokane, United StatesTaking people
- SpringfieldSpringfield, United StatesTaking people
- St. PetersburgSt. Petersburg, United StatesTaking people
- StanfordStanford, United StatesTaking people
- SyracuseSyracuse, United StatesTaking people
- TacomaTacoma, United StatesTaking people
- TamaracTamarac, United StatesTaking people
- The BronxThe Bronx, United StatesTaking people
- TorranceTorrance, United StatesTaking people
- TuscaloosaTuscaloosa, United StatesTaking people
- TylerTyler, United StatesTaking people
- UplandUpland, United StatesTaking people
- VallejoVallejo, United StatesTaking people
- West HollywoodWest Hollywood, United StatesTaking people
- WestwoodWestwood, United StatesTaking people
- White PlainsWhite Plains, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Summit Therapeutics
- Trial code
- NCT07228832
- Record updated
- 5 November 2026
- Original description
A Randomized, Active-Controlled, Double-blind, Multicenter, Phase 3 Clinical Study of Ivonescimab in Combination with mFOLFOX6 (Oxaliplatin, Leucovorin and 5-Fluorouracil) versus Bevacizumab in Combination with FOLFOX for the First-line Treatment of Metastatic Colorectal Cancer(HARMONi-GI3)Read full original descriptionShow less
A Randomized, Active-Controlled, Double-blind, Multicenter, Phase 3 Clinical Study of Ivonescimab in Combination With FOLFOX Versus Bevacizumab in Combination With FOLFOX for the First-line Treatment of Metastatic Colorectal Cancer
A Randomized, Active-Controlled, Double-blind, Multicenter, Phase 3 Clinical Study of Ivonescimab in Combination with mFOLFOX6 (Oxaliplatin, Leucovorin and 5-Fluorouracil) versus Bevacizumab in Combination with FOLFOX for the First-line Treatment of Metastatic Colorectal Cancer(HARMONi-GI3)
Inclusion: ECOG performance status score of 0 or 1; Expected life expectancy ≥ 6 months; Patients with histologically or cytologically confirmed metastatic CRC; No prior systemic therapy for metastatic CRC; At least 1 measurable noncerebral lesion.
Exclusion: Patients who have received prior immunotherapy or anti-angiogenic therapy for colorectal cancer; Active or prior history of inflammatory bowel disease (eg, Crohn's disease, ulcerative colitis, or chronic diarrhea); Microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) disease; Resectable disease; Known BRAF V600E mutant status; Current presence of significant radiographic or clinical manifestations of gastrointestinal (GI) obstruction; Ascites requiring paracentesis within last 30 days.