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Heart function test using impedance cardiography in people with aortic stenosis

Tests a heart signal test for spotting heart muscle strain in aortic stenosis.

Key facts

Who runs it
Dermed Diagnostics, Inc.
Where
Chicago, United StatesSee the site
Trial code
Registry title
Correlation Between an Impedance Cardiography Test for Decompensation and the Development of Left Ventricular Replacement Fibrosis
Status
Recruiting
People taking part
6 people, planned
Started
30 Apr 2026
Expected to end
30 Nov 2026
Type of study
Interventional
Treatments tested
  • Impedance Cardiography Upright/Supine Test
Record updated
5 May 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with moderate or severe aortic stenosis (narrowing of the heart's main valve) who have had or will have a heart MRI scan with contrast. It tests a skin-electrode heart test called HYPERGRAPH.

Age
18 years and older.
Sex
Men and women can join.
Disease stage
Moderate aortic stenosis without scarring of the heart muscle (replacement fibrosis), or moderate aortic stenosis with symptoms and scarring, or severe aortic stenosis with scarring before valve replacement.
Earlier treatment
A recent heart MRI (CMR) with late gadolinium enhancement, or one already scheduled. For severe stenosis, before aortic valve replacement.

Main reasons for not taking part

  • Past heart attack or cardiac amyloidosis.
  • Any metal or implant, such as an IUD, braces, eye metal fragments, pacemakers, defibrillators or other electronic heart implants.
  • Pregnant or breastfeeding women.
  • Fear of small places, or severe obesity (BMI > 40).
  • Skin problems such as rashes or open wounds where electrodes go, or cannot give consent in English.

The registry criteria, word for word

Show all 2 criteriaShow less

Who can take part

  • • Male or female at least 18 years of age; No prior history of myocardial infarction or cardiac amyloidosis; Recent CMR scan with late gadolinium enhancement or scheduled for CMR scan with late gadolinium enhancement; A history of:; Moderate aortic stenosis and no replacement fibrosis OR Moderate aortic stenosis and symptoms who has replacement fibrosis OR Severe aortic stenosis with replacement fibrosis prior to aortic valve replacement; Able to comprehend and provide informed consent in English; Participants must have intact, healthy skin at the electrode application sites

Who cannot take part

  • • Under 18 years of age; Pregnant or breastfeeding women; Unable to consent; Prisoners; History of myocardial infarction; History of cardiac amyloidosis; Patients with any metal or implant such as IUD, braces, metal fragments implants in the eye, pacemakers (especially Minute Ventilation pacemakers with the MV function activated) defibrillators, or any other electronic cardiac implant; Claustrophobic or afraid or small places; Severe obesity (BMI > 40) that impairs accurate ICG measurement due to difficulties in electrode placement or excessive impedance; Active skin conditions, such as rashes, open wound or significant skin sensitivity at the electrode placement sites

Where in United States

  • Northwestern UniversityChicago, United StatesContact: Michael Markl, PhDTaking people

About the trial

What the trial wants to find out

The purpose of this study is to evaluate the effectiveness of impedance cardiography (ICG), the HYPERGRAPH test, in detecting left ventricular decompensation in patients with aortic stenosis, compared to cardiac magnetic resonance (CMR) imaging findings. The study aims to obtain usable ICG test data on six patients with aortic stenosis who have recently undergone CMR scans with late gadolinium enhancement, and who do not have a history of myocardial infarction or cardiac amyloidosis. The hypothesis to be tested is that the HYPERGRAPH can accurately detect left ventricular decompensation associated with replacement fibrosis obtained from CMR imaging.

The group in the trial

  • Impedance cardiography testTreatment being tested

    The ICG upright/supine test, using the HYPERGRAPH, will be used to show the difference in the compensatory response between normal LV function and decompensation in HF.

    Treatment: Impedance Cardiography Upright/Supine Test

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Early Feasibility Study of the Correlation Between an Impedance Cardiography Test for Decompensation and the Development of Left Ventricular Replacement Fibrosis
Plain-language title
Heart function test using impedance cardiography in people with aortic stenosisGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 14 November 2026.
Record updated
5 May 2026