Heat treatment after removing large colon polyps to prevent regrowth
Tests added heat treatment after removing large flat colon polyps, in adults.
Plain-language title generated from the registry record
Registry title: Reducing Neoplasia Recurrence After Non-thermal Endoscopic Resection of Large Colorectal Polyps
Key facts
- Where
- Montreal, CanadaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults having endoscopic removal (EMR) of a large, flat colorectal polyp of 20 mm or more. It tests whether extra heat treatment of the removal site lowers the chance the polyp comes back.
- Age
- 18 years or older
- Sex
- All sexes can join.
- Disease stage
- Large, flat colorectal polyp (laterally spreading lesion) of 20 mm or more, planned for endoscopic mucosal resection (EMR).
Main reasons for not taking part
- Inflammatory bowel disease
- Colonoscopy that was not planned in advance (non-elective)
- Poor general health (American Society of Anesthesiologists class above III)
- Bleeding or clotting problem, or low platelets (INR 1.5 or higher, or platelets under 50*10^9/L)
- Bulky lesions (granular mixed with a nodule of 10 mm or more)
Read by machine on 12 November 2026.
Where in Canada
- Centre Hospitalier de l'Université de MontréalMontreal, CanadaContact: Samira HaninNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Centre hospitalier de l'Université de Montréal (CHUM)
- Trial code
- NCT07242820
- Record updated
- 14 August 2026
- Original description
The goal of this clinical trial is to clarify the role of adjuvant thermal ablation for non-thermal endoscopic mucosal resection (EMR) of large (≥20mm) flat colorectal polyps (so-called laterally spreading lesions [LSLs]).Read full original descriptionShow less
Reducing Neoplasia Recurrence After Non-thermal Endoscopic Resection of Large Colorectal Polyps
The goal of this clinical trial is to clarify the role of adjuvant thermal ablation for non-thermal endoscopic mucosal resection (EMR) of large (≥20mm) flat colorectal polyps (so-called laterally spreading lesions [LSLs]).
The hypothesis is that adding adjuvant thermal ablation to non-thermal EMR (vs no ablation) will result in lower lesion recurrence rates at 6-month follow-up, and non-inferior adverse events (AE) rates 14 days post EMR.
For participants with planned EMR, endoscopists will perform non-thermal EMRs as per standard of care and:
* adjuvant thermal ablation will either not be performed (control group), or will be applied to the base and outside margins of the resection site (experimental group); * then, all patients will be contacted 14-44 days after EMR, to verbally ascertain the occurrence of AEs; * then, all patients will undergo a first follow-up colonoscopy at 6 months after initial conoloscopy to assess lesion recurrence; * finally, all patients will undergo a second and final colonoscopy 18 months after EMR.
Inclusion: Adult patients; Undergoing EMR for large (≥20 mm) colorectal LSL; Providing written and informed consent for study participation.
Exclusion: Inflammatory bowel disease; Coagulopathy or thrombocytopenia (international normalized ration ≥1.5 or platelets <50*10\^9/L); Non-elective colonoscopy; Poor general health (American Society of Anesthesiologists classification >III); Bulky lesions (granular mixed with ≥10mm module).