High blood pressure in young people at risk of inherited polycystic kidney disease
Looks at blood pressure and kidney scans in young people at risk of ADPKD.
Plain-language title generated from the registry record
Registry title: Hypertension in Children and Young People at Risk of Autosomal Dominant Polycystic Kidney Disease
Key facts
- Where
- London, United KingdomSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 12 and 17 years old?
Source: NCT07260071, who can take part
Where in United Kingdom
- Evelina London Children's HospitalLondon, United KingdomTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- King's College London
- Trial code
- NCT07260071
- Record updated
- 4 November 2026
- Original description
The goal of this project is to measure the prevalence of Autosomal Dominant Polycystic Kidney Disease (ADPKD) and hypertension in the general population of children and young people at risk of ADPKD, using magnetic resonance imaging (MRI) for rapid diagnosis alongside genetic testing. The main question it aims to answer is:Read full original descriptionShow less
Family Study of Early Hypertension in Children and Young People at Risk of Autosomal Dominant Polycystic Kidney Disease
The goal of this project is to measure the prevalence of Autosomal Dominant Polycystic Kidney Disease (ADPKD) and hypertension in the general population of children and young people at risk of ADPKD, using magnetic resonance imaging (MRI) for rapid diagnosis alongside genetic testing. The main question it aims to answer is:
What is the prevalence of hypertension in a population sample of adolescents with ADPKD?
Participants will have the following measurements performed:
* Height and weight. * Blood pressure. * Non-invasive measurement of arterial stiffness. * Cardiac and renal MRI. * Blood sample. * Genetic testing.
Inclusion: Age 12 - 17 years at the time of consent; Able to tolerate the key study investigations (office blood pressure measurement, ambulatory blood pressure measurement, MRI and blood test); Parent with confirmed clinical diagnosis of ADPKD; Parent (if child <16 years) or both parent and young person (if >=16 years) consents to genetic testing for ADPKD and demonstrates understanding of the implications of this.
Exclusion: Presence of associated co-morbidities which make it difficult to interpret results, including congenital cardiac anomalies and known TSC-PKD1 mutations; 18 years or above at the time of study entry; Unable to tolerate key study investigations; Unwilling to undergo genetic testing for ADPKD.