Semaglutide and Changes in Heart and Muscle Mass Over 12 Months
Uses MRI to track muscle and fat changes in adults starting semaglutide.
Plain-language title generated from the registry record
Registry title: Impact of Semaglutide (Ozempic/Wegovy®) on Heart and Muscle Mass
Key facts
- Where
- Edmonton, CanadaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT07272837, who can take part
Where in Canada
- Mazankowski Alberta Heart InstituteEdmonton, CanadaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Alberta
- Trial code
- NCT07272837
- Record updated
- 17 July 2026
- Original description
The aim of this study is to use advanced MRI scans to track changes in both muscle and fat in the body and heart over a 12-month period in individuals starting semaglutide. By doing so, we hope to gain a clearer understanding of how semaglutide affects muscle health and function. Our goal is to ensure the medication supports long-term well-being, particularly for people who may be at higher risk of muscle loss.Read full original descriptionShow less
GLP-1 Receptor Agonist-Induced Muscle Mass Evaluation and Retention
The aim of this study is to use advanced MRI scans to track changes in both muscle and fat in the body and heart over a 12-month period in individuals starting semaglutide. By doing so, we hope to gain a clearer understanding of how semaglutide affects muscle health and function. Our goal is to ensure the medication supports long-term well-being, particularly for people who may be at higher risk of muscle loss.
This study involves (3) in-person study visits. At each visit, participants will be asked to:
* Undergo magnetic resonance imaging (MRI) while resting and during exercise to take pictures of their heart, abdomen, and legs. * Complete tests to assess balance, sit-to-stand, walking speed, and handgrip strength. * Complete questionnaires related to demographics, health information, physical activity, and nutrition. * Have a blood sample collected from a vein in your arm. * Have your blood levels assessed through three finger pricks. * Complete three days of food records.
Inclusion: Adults 18-80 years of age; Starting semaglutide for type 2 diabetes or weight loss; Able to safely undergo an MRI scan (including meeting the physical requirements for MRI equipment).
Exclusion: Concerns related to MRI use (including magnetic implants, pacemaker, severe claustrophobia); Major recent heart issues or other severe health conditions; Current use of semaglutide for more than 2 weeks; Dependence on a mobility aid (unable to participate in exercise MRI).