Planning a future trial of add-on treatments for people in hospital with heart failure
Gathers views from clinicians, patients and carers to design a heart failure trial.
Plain-language title generated from the registry record
Registry title: Preparatory Work for a Trial of Adjuncts to Diuretic Treatment in Patients Hospitalised With Heart Failure: Addressing Uncertainties and Building Consensus
Key facts
- Where
- Hull, United KingdomSee the site
Where in United Kingdom
- CardiologyHull, United KingdomTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Hull University Teaching Hospitals NHS Trust
- Trial code
- NCT07281040
- Record updated
- 15 December 2025
- Original description
Aims and ObjectivesRead full original descriptionShow less
Preparatory Work for a Multi-arm, Multi-stage Trial of Adjunctive Treatments in Patients Hospitalised With Heart Failure (Pre-MAMMOTH-HF)
Aims and Objectives
1. Choose which adjunctive therapies, at what dose, and for how long 2. Choose the dose(s) of IV furosemide to be used as the comparator 3. Choose primary and secondary outcomes 4. Estimate recruitment and engage sites for a future trial
Work package 2a methods overview
1. An online survey of clinicians (doctors, nurses and pharmacists) assessing potential ability to recruit and the acceptability of each adjunct and willingness to support a trial. 2. Evidence generated (survey and reviews) will be considered by an expert panel (N=20-25) including expert clinicians and allied health professionals who care for people with HF using a modified Delphi approach. The panel will make recommendations on all aspects of the trial design. 3. A patient and carer panel of people with a recent hospitalisation (<6 months) for HF will provide recommendations on trial endpoints. The patient-and-carer advisory group (PCAG) will also input into these discussions.
Inclusion: Recent hospitalisation with heart failure (<6 months) or carer for a person with a recent hospitalisation with heart failure; Able to participate in online group discussions in English.
Exclusion: Unable to participate in online group discussions in English.