Planning a future trial of add-on treatments for people in hospital with heart failure
Gathers views from clinicians, patients and carers to design a heart failure trial.
Key facts
- Who runs it
- Hull University Teaching Hospitals NHS Trust
- Where
- Hull, United KingdomSee the site
- Trial code
- Registry title
- Preparatory Work for a Trial of Adjuncts to Diuretic Treatment in Patients Hospitalised With Heart Failure: Addressing Uncertainties and Building Consensus
- Status
- Recruiting
- People taking part
- 10 people, planned
- Started
- 2 Jul 2025
- Planned end
- 1 Oct 2026
- Type of study
- Observational
- Treatments tested
- Patient and carer panel using nominal group approach and thematic analysis
- Record updated
- 15 December 2025
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults who were in hospital for heart failure in the last 6 months, or who care for such a person. They must be able to join online group talks in English.
- Age
- 18 Years or older
- Sex
- Women and men can join.
- Disease stage
- Heart failure that led to a hospital stay in the last 6 months (less than 6 months ago).
Main reasons for not taking part
- People who cannot take part in online group discussions in English cannot join.
The registry criteria, word for word
Show all 3 criteriaShow less
Who can take part
- Recent hospitalisation with heart failure (<6 months) or carer for a person with a recent hospitalisation with heart failure
- Able to participate in online group discussions in English
Who cannot take part
- Unable to participate in online group discussions in English
Where in United Kingdom
- CardiologyHull, United KingdomContact: Joe Cuthbert, MBBS MDTaking people
About the trial
What the trial wants to find out
Aims and Objectives
Read full original descriptionShow less
1. Choose which adjunctive therapies, at what dose, and for how long 2. Choose the dose(s) of IV furosemide to be used as the comparator 3. Choose primary and secondary outcomes 4. Estimate recruitment and engage sites for a future trial
Work package 2a methods overview
1. An online survey of clinicians (doctors, nurses and pharmacists) assessing potential ability to recruit and the acceptability of each adjunct and willingness to support a trial. 2. Evidence generated (survey and reviews) will be considered by an expert panel (N=20-25) including expert clinicians and allied health professionals who care for people with HF using a modified Delphi approach. The panel will make recommendations on all aspects of the trial design. 3. A patient and carer panel of people with a recent hospitalisation (<6 months) for HF will provide recommendations on trial endpoints. The patient-and-carer advisory group (PCAG) will also input into these discussions.
Treatments tested
- Patient and carer panel using nominal group approach and thematic analysis
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Preparatory Work for a Multi-arm, Multi-stage Trial of Adjunctive Treatments in Patients Hospitalised With Heart Failure (Pre-MAMMOTH-HF)
- Plain-language title
- Planning a future trial of add-on treatments for people in hospital with heart failureGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 15 December 2025