Testing Low-Dose Naltrexone Doses in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Tests different doses of low-dose naltrexone in adults with ME/CFS.
Plain-language title generated from the registry record
Registry title: Low-Dose Naltrexone For ME/CFS: Dose-Finding
Key facts
- Where
- Birmingham, United StatesSee the site
- Phase
- Phase 2
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT07285473, who can take part
Where in United States
- University of Alabama at BirminghamBirmingham, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Alabama at Birmingham
- Trial code
- NCT07285473
- Record updated
- 8 October 2026
- Original description
This exploratory clinical trial tests low-dose naltrexone (LDN) for the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). A remote trial approach is used, with eligibility open to the state of Alabama.Read full original descriptionShow less
Low-dose Naltrexone (LDN) for the Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Dose-Finding
This exploratory clinical trial tests low-dose naltrexone (LDN) for the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). A remote trial approach is used, with eligibility open to the state of Alabama.
Inclusion: Between ages of 18 and 65; Living in Alabama; Meets ME-ICC criteria.
Exclusion: Evidence of active or chronic systemic infection; Auto-immune disorder; Abnormal complete blood count; Abnormal hepatic function; Abnormal renal function; A1C > 9.0%; Current opioid analgesic use; Pregnant or plans to become pregnant during the study participation period; Enrolled in other experimental treatment study.