Tests a weight management program for adults who stopped obesity medicine
Tests a primary care weight program for adults who stopped obesity medication.
Key facts
- Who runs it
- Rush University Medical Center
- Where
- Chicago, United StatesSee the site
- Trial code
- Registry title
- PRImary Care Strategies for Weight Management (PRISM) Study
- Status
- Recruiting
- People taking part
- 214 people, planned
- Started
- 4 Jun 2026
- Expected to end
- 1 Apr 2028
- Type of study
- Interventional, 2 groupsOne group gets no study treatment, for comparison.
- Treatments tested
- PRISM Program
- Record updated
- 9 July 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults who were prescribed a weight-loss medicine by a primary care provider at Rush and then stopped taking it. It tests a program to help manage weight.
- Age
- 18 years or older
- Sex
- All sexes can join.
- Disease stage
- Obesity. People with a body mass index of 60 kg/m2 or more, or a body weight of 375 pounds (170 kg) or more, cannot join.
- Earlier treatment
- Must have been prescribed liraglutide, semaglutide, tirzepatide or a newer FDA-approved long-term obesity medicine by a primary care provider at Rush University System for Health, and have received at least one dose. For the randomised part, must have stopped the medicine.
Main reasons for not taking part
- Not fluent in English
- Diabetes (type 1 or type 2)
- Current or planned pregnancy
- Bariatric surgery in the past 2 years or planned bariatric surgery
- No home WIFI and no smartphone with data
The registry criteria, word for word
Show all 14 criteriaShow less
Who can take part
- For run-in: prescribed liraglutide, semaglutide, or tirzepatide or newer medication approved by the FDA for long-term use for obesity treatment for the purpose of weight managment by a primary care provider at Rush University System for Health and have received at least one dose of the medication concurrent with enrollment in the study
- For randomization: discontinue their prescribed anti-obesity medication
- Age 18+
Who cannot take part
- Bariatric surgery in the past 2 years or planned bariatric surgery
- Concurrent engagement with other behavioral treatments for obesity (for randomized phase only)
- Medication obtained from online/compound pharmacies or prescription from specialty clinic without a prescription from primary care team at the time of enrollment
- Diagnosis of diabetes (type 1 or type 2)
- Medical contraindications to treatment, including significant cognitive impairment, active substance abuse based on the World Health Organization's ASSIST screener, or serious medical illness (e.g., stage 3 or 4 heart failure, cancer, renal failure, etc.)
- Not fluent in English
- Current or planned pregnancy
- Body mass index ≥60 kg/m2, due to increased injury risk with exercise
- Body weight ≥ 375 pounds (scale capacity with a margin for regain)
- No access to home WIFI or a smartphone with data available
- Another member of the household is enrolled in the study
Where in United States
- Rush University Medical CenterChicago, United StatesContact: Melissa CraneTaking people
About the trial
What the trial wants to find out
The goal of this clinical trial pilot is to determine the feasibility of an intervention to enhance weight management in patients who have stopped taking anti-obesity/weight management medications in primary care. The main questions it aims to answer are:
Read full original descriptionShow less
* Can patients be recruited into the study efficiently? * Is the program acceptable to patients? * Can the study be conducted efficiently?
The new program will be compared to usual care.
The 2 groups in the trial
- PRISM ProgramTreatment being tested
This is a novel, remotely delivered, self-tailored intervention for post-anti-obesity medication discontinuation weight management.
- Usual CareNo study treatment, for comparison
Participants will continue to receive their regular, usual primary care.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Primary-Care Strategies to Enhance Weight Management (PRISM) After Discontinuation of Anti-Obesity Medications
- Plain-language title
- Tests a weight management program for adults who stopped obesity medicineGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 9 July 2026