Studies how vagus nerve stimulation affects brain activity in treatment-resistant depression
Tests an implanted nerve stimulator in adults with depression that has not responded to treatment.
Plain-language title generated from the registry record
Registry title: Vagus Nerve Stimulation (VNS) Electroencephalogram (EEG) Protocol Supplement
Key facts
- Where
- Stanford, United StatesSee the site
Where in United States
- Department of Psychiatry and Behavioral Sciences, Stanford School of MedicineStanford, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Stanford University
- Trial code
- NCT07310381
- Record updated
- 2 November 2026
- Original description
The study will examine the autonomic, physiologic and neurophysiologic effects of implanted Vagus Nerve Stimulation (VNS) in treatment-resistant depression patients.Read full original descriptionShow less
Vagus Nerve Stimulation (VNS) Electroencephalogram (EEG) Protocol Supplement
The study will examine the autonomic, physiologic and neurophysiologic effects of implanted Vagus Nerve Stimulation (VNS) in treatment-resistant depression patients.
Inclusion: Participants must be at least 18 years old; Participants must be able to read, understand and have the capacity to provide written informed consent and Health Insurance Portability and Accountability Act (HIPAA) authorization; Proficiency in English sufficient to complete questionnaire and follow instructions during fMRI assessments and iTBS interventions; Willingness to comply with all study procedures and the ability to communicate with study personnel about adverse events and other clinically important information; Participant must be currently implanted with a VNS device for the clinical indication of Major Depressive Disorder (MDD); Clinical Indication of MDD as defined: Participant has a diagnosis of chronic (≥ 2 years) or ≥ 4 recurrent depressive episodes as defined by DSM-5 criteria documented using the MINI criteria and psychiatric medical record review; Access to ongoing psychiatric care before and after completion of the study; In good general health, as evidenced by medical history; Agreement to adhere to Lifestyle Considerations throughout study duration.
Exclusion: Medication Contraindications; Participant does not speak or read English; Any other clinical reasons deemed by the investigator of the study for which the participant would not be an appropriate candidate for the study; Contraindication to EEG.