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Taking people in PolandNo phase

Studying Crohn's disease risk in relatives of people with the disease

Studies blood and lifestyle factors to predict Crohn's disease in young adult relatives.

Key facts

Who runs it
GLSMED Learning Health S.A.
Where
Warsaw, PolandSee the siteAlso in 5 other countries, 9 sites
Trial code
Registry title
Prospective Risk Evaluation and Detection of Crohn's Disease in First-degree Relatives
Status
Recruiting
People taking part
10,000 people, planned
Started
1 Apr 2026
Expected to end
31 Dec 2029
Type of study
Observational
Record updated
29 July 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for young first-degree relatives of people with Crohn's disease, to test a score that predicts who may develop the disease.

Age
16 to 35 years
Sex
Men and women
Disease stage
Not asked for. Participants must be a parent, full sibling or child of a person with an established Crohn's disease diagnosis.

Main reasons for not taking part

  • Prior diagnosis of IBD
  • Any legal or medical condition that limits information and participation in the study
  • Crohn's disease diagnosis of the relative cannot be verified
  • Unwilling or unable to give written informed consent
  • Unwilling or unable to donate blood for serum

The registry criteria, word for word

Show all 8 criteriaShow less

Who can take part

  • Male or female participants, between 16 and 35 years old
  • FDR (parent, full-siblings or offspring) from a patient with an established diagnosis of CD
  • Participants able to understand the information provided to them and to give written informed assent or consent for the study

Who cannot take part

  • Prior diagnosis of IBD
  • Any legal or medical condition that limits the information and participation in the study
  • Participants unwilling or unable to donate blood for serum
  • Inability to verify CD diagnosis in the proband
  • Participants unwilling or unable to provide informed written consent

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 16 and 35 years old?

Where in Poland

Also in 5 other countries, 9 sites

  • Państwowy Instytut Medyczny MSWiA w WarszawieWarsaw, PolandContact: Magdalena Kaniewska, MDTaking people

About the trial

What the trial wants to find out

The PREDICT-CD study aims to validate a risk score for the development of Crohn's disease, based on serological biomarkers and lifestyle-related factors. Given that having a family member with the disease is the strongest known risk factor, the target population will consist of first-degree relatives (aged 16 to 35) of individuals diagnosed with Crohn's disease.

Read full original descriptionShow less

This study will be conducted within Work Package 3 (WP3) of the INTERCEPT project, a consortium funded by the Innovative Health Initiative (IHI). The research will take place across 28 centres in seven countries: Portugal, Spain, France, Italy, the Netherlands, Sweden, and Poland.

To achieve the study objectives, individuals with Crohn's disease (referred to as patients) will be invited to participate and to engage their eligible first-degree relatives. At the baseline visit, the patient's physician will complete a clinical questionnaire covering disease history, treatments, and previous interventions.

At the same time, first-degree relatives (parents, siblings, or children) will donate a blood sample for serum isolation and, optionally, a whole blood and stool sample. They will also complete a questionnaire regarding their health status, habits, and preferences. Follow-up questionnaires will be administered every six months to monitor the onset of symptoms or behavioural changes.

The group in the trial

  • First-degree relatives

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Prospective Risk Evaluation and Detection of Crohn's Disease in First-degree Relatives
Plain-language title
Studying Crohn's disease risk in relatives of people with the diseaseGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Fit questions
Built from NCT07316621, who can take part
Record updated
29 July 2026