Personalized Ablation Guided by Non-Invasive Mapping for Atrial Fibrillation
Tests a mapping-guided heart procedure to treat atrial fibrillation in adults.
Plain-language title generated from the registry record
Registry title: Personalized Atrial Fibrillation Ablation Guided by Non-Invasive Global Mapping
Key facts
- Where
- Berlin and Frankfurt am Main, GermanySee the 2 sites
Where in Germany
- German Heart Center of the Charité, Charité University Hospital BerlinBerlin, GermanyTaking people
- Frankfurt University Heart and Vascular CenterFrankfurt am Main, GermanyNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- German Heart Institute
- Trial code
- NCT07320560
- Record updated
- 6 January 2026
- Original description
This pilot study investigates if non-invasive global mapping can guide catheter ablation of atrial fibrillation (AF) by defining personalized targets based on the temporal Stability of local Atrial High-Rate Activity (SAHRA). The study also assesses efficacy and safety of this approach and evaluates potential signals of harm. The main questions it aims to answer are:Read full original descriptionShow less
Personalized Atrial Fibrillation Ablation Guided by Non-Invasive Global Mapping - the CURE-AF Pilot Study
This pilot study investigates if non-invasive global mapping can guide catheter ablation of atrial fibrillation (AF) by defining personalized targets based on the temporal Stability of local Atrial High-Rate Activity (SAHRA). The study also assesses efficacy and safety of this approach and evaluates potential signals of harm. The main questions it aims to answer are:
* Does ablation of targets defined by non-invasive global mapping improve rates of acute atrial fibrillation termination? * Does such a personalized ablation approach reduce arrhythmia recurrence rates? Researchers will compare the results of the personalized ablation approach with comparable patients that had undergone a conventional "empirical" ablation approach (pulmonary vein isolation).
Participants will:
* Undergo a personalized catheter ablation approach employing both a non-invasive global mapping system and a conventional intracardiac mapping system * Visit the clinic 3, 6 and 12 months after ablation for clinical follow-up * Schedule a telephone visit 9 and 24 months after ablation for clinical follow-up
Inclusion: Ablation-naïve patients with:; Persistent AF planned for catheter ablation plus; Left atrial enlargement (LA diameter ≥45 mm or LA volume index ≥35ml/m2 or LA area ≥20 cm2).
Exclusion: Previous cardiac ablation; Previous stroke/TIA; Dermal disease or hypersensitivity predisposing for skin irritation or exanthema; Severe left ventricular dysfunction (LVEF <35%); Renal failure (GFR <30 ml/min); Age <18 years; Pregnancy or lactation.