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Talk therapy for insomnia and its effect on blood sugar and insulin resistance

Tests talk-based insomnia therapy against sleep habit advice in adults with insomnia.

Key facts

Who runs it
University of Missouri-Columbia
Where
Columbia, United StatesSee the site
Trial code
Registry title
Insomnia and Insulin Resistance
Status
Recruiting
People taking part
20 people, planned
Started
20 Sept 2026
Expected to end
1 Jun 2027
Type of study
Interventional, 2 groupsOne group gets an existing treatment, for comparison.
Treatments tested
  • CBT-I
  • sleep hygiene
Record updated
24 September 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with insomnia and a raised body weight. It compares CBT-I, a talk-based sleep therapy, with sleep hygiene advice over 5 weeks.

Age
18 to 50 years
Sex
All sexes can join.
Disease stage
Insomnia with a score of 15 or more on the Insomnia Severity Index. BMI 28-45 kg/m2.
Earlier treatment
People already getting behavioral treatment for insomnia cannot join. People using GLP-1 agonists or taking insulin cannot join.

Main reasons for not taking part

  • Mania, seizure disorder, psychosis or suicidal thoughts
  • Monthly illegal drug use, such as cocaine or opioids
  • Clear heart disease, kidney disease, thyroid disease or cancer
  • Pregnancy
  • Currently dieting

The registry criteria, word for word

Show all 2 criteriaShow less

Who can take part

  • ages 18-50 y BMI 28-45 kg/m2 Score on the Insomnia Severity Index ≥15

Who cannot take part

  • contraindications for CBT-I (mania or seizure disorder) symptoms requiring immediate attention (e.g., psychosis, suicide intent) report illicit substance use on a monthly basis (e.g., cocaine, opioids) receiving behavioral treatment for insomnia overt cardiovascular disease overt renal disease thyroid disease cancer pregnant dieting using GLP-1 agonists taking exogenous insulin

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 18 and 50 years old?

Where in United States

  • University of MissouriColumbia, United StatesContact: Jill A Kanaley, PhDTaking people

About the trial

What the trial wants to find out

Insomnia symptoms are linked to metabolic syndrome (MetS), which includes abnormal glucose metabolism, insulin resistance (IR), and incidence of diabetes. Chronic sleep deficit is a major predictor of disease and early mortality. Further, insomnia is the most common sleep disorder in the United States. The recommended first line of treatment for insomnia is Cognitive Behavioral Therapy for Insomnia (CBT-I). CBT-I is a multidimensional treatment that targets the thoughts and behaviors that perpetuate insomnia symptoms over time. This study will explore CBT-I effects on MetS outcomes (ie. blood pressure, triglycerides, etc.) and provide preliminary evidence that CBT-I impacts IR and fasting glucose concentrations within this population.

Read full original descriptionShow less

20 subjects with insomnia will be recruited. They will be randomly assigned to either CBT-i or sleep hygiene. The intervention is 5 wks. Pre and post intervention, the investigator will have participants fill out a number of questionnaires, a daily sleep diary, 2 weeks of actigraphy measuring sleep and physical activity and there will be a single blood draw at the beginning and the end of the study.

The 2 groups in the trial

  • CBT-1Existing treatment, for comparison

    treatment with cognitive behavior therapy for insomnia this is behaviorial therapy that meets with a "coach" once a week for 5 wk

    Treatment: CBT-I

  • sleep hygienePlacebo, for comparison

    treatment with sleep hygiene group meets with a coach once at the beginning of the intervention period

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Insomnia, Metabolic Syndrome and Insulin Resistance
Plain-language title
Talk therapy for insomnia and its effect on blood sugar and insulin resistanceGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 14 November 2026.
Fit questions
Built from NCT07333586, who can take part
Record updated
24 September 2026