DHA Supplement Plus Exercise in People With Multiple Sclerosis
Tests DHA supplements combined with exercise in adults with multiple sclerosis.
Plain-language title generated from the registry record
Registry title: Effects of DHA in Patients With Multiple Sclerosis
Key facts
- Where
- La Ñora, SpainSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with multiple sclerosis who have had no flare-ups in the last month and have mild to moderate disability.
- Age
- 18 to 65 years (approximately)
- Sex
- All
- Disease stage
- Multiple sclerosis diagnosed by the McDonald criteria, with an EDSS score of 0.00 to 6, and no flare-up in the previous month.
- Biomarker or test result
- Must be able to activate the tibialis anterior muscle (a muscle at the front of the lower leg).
Main reasons for not taking part
- Not meeting the inclusion criteria
- Any problem performing the tests
- Any problem taking the supplement or placebo
Read by machine on 9 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT07346703, who can take part
Where in Spain
- Research Center for High Performance Sport. Universidad Católica de MurciaLa Ñora, SpainNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Francisco Javier Martínez Noguera
- Trial code
- NCT07346703
- Record updated
- 16 January 2026
- Original description
This clinical trial will investigate the effects of combining therapeutic exercise with DHA supplementation in 100 patients with multiple sclerosis using a randomized controlled design. Participants, diagnosed according to the McDonald criteria, will undergo functional, cognitive, fatigue, and quality-of-life assessments through tools such as the EDSS, BRB-N, MFIS, EVA-f, and MSQoL-54. Physiological evaluations will include infrared thermography, isokinetic strength testing, perceived exertion (Modified Borg Scale), balance (Timed Up and Go), lower-limb power (Sit-to-Stand app), and handgrip strength. The study hypothesizes that this combined intervention will improve motor function, cognition, fatigue management, and overall quality of life by enhancing neuromuscular activation and metabolic efficiency.Read full original descriptionShow less
Effects of Therapeutic Exercise and Long-term Docosahexaenoic Acid (DHA) Supplementation on Physical, Physiological, Motor, Mental, and Cognitive Variables in Patients With Multiple Sclerosis.
This clinical trial will investigate the effects of combining therapeutic exercise with DHA supplementation in 100 patients with multiple sclerosis using a randomized controlled design. Participants, diagnosed according to the McDonald criteria, will undergo functional, cognitive, fatigue, and quality-of-life assessments through tools such as the EDSS, BRB-N, MFIS, EVA-f, and MSQoL-54. Physiological evaluations will include infrared thermography, isokinetic strength testing, perceived exertion (Modified Borg Scale), balance (Timed Up and Go), lower-limb power (Sit-to-Stand app), and handgrip strength. The study hypothesizes that this combined intervention will improve motor function, cognition, fatigue management, and overall quality of life by enhancing neuromuscular activation and metabolic efficiency.
Inclusion: The patient sample comes from the Multiple Sclerosis Association (AMDEM) of the Murcia region and the neurology department of the Ribera Salud Hospital in Molina de Segura. Patients diagnosed with multiple sclerosis according to the McDonald criteria, aged between 18 and 65 (approximately), who have not suffered any flare-ups in the previous month and who have a score of 0.00 to 6 on the Expanded Disability Status Scale (EDSS) and are able to activate the tibialis anterior muscle will be eligible for the study.
Exclusion: Not fulfilling the inclusion criteria; Having any problems performing the tests; Having any problems taking the supplement or placebo.