Breathing muscle training at home for older adults at risk of dementia
Tests a home breathing muscle training device in adults aged 60 to 80.
Plain-language title generated from the registry record
Registry title: IMST for Dementia Risk Reduction
Key facts
- Where
- Tallahassee, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 60 and 80 years old?
Source: NCT07349706, who can take part
Where in United States
- Florida State UniversityTallahassee, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Florida State University
- Trial code
- NCT07349706
- Record updated
- 4 November 2026
- Original description
Using a 2-arm, RCT approach, the primary goal of the study is to evaluate the feasibility and preliminary efficacy of Inspiratory Muscle Strength Training (IMST) as a non-pharmacologic intervention to reduce cardiovascular and cognitive risks in older adults. Next, investigators will examine secondary effects of IMST on mood, sleep quality, systemic inflammation, and physical/motor function. Finally, investigators will assess participant adherence and acceptability ratings of using an 8-week home-based IMST protocol in a diverse older adult sample.Read full original descriptionShow less
Randomized Controlled Pilot Trial of Inspiratory Muscle Strength Training (IMST) to Reduce Dementia Risk in Older Adults
Using a 2-arm, RCT approach, the primary goal of the study is to evaluate the feasibility and preliminary efficacy of Inspiratory Muscle Strength Training (IMST) as a non-pharmacologic intervention to reduce cardiovascular and cognitive risks in older adults. Next, investigators will examine secondary effects of IMST on mood, sleep quality, systemic inflammation, and physical/motor function. Finally, investigators will assess participant adherence and acceptability ratings of using an 8-week home-based IMST protocol in a diverse older adult sample.
Inclusion: Ages 60-80; Converted telephone MoCA total score≥18; Presence of at least one dementia risk factor (e.g., MCI or subjective cognitive decline, hypertension [SBP >130 mmHg or on medication], sedentary lifestyle [<150 min/week], family history of dementia or self-reported APOE ε4 carrier, or mild sleep-disordered breathing; CAIDE total score [>5]; Capable of independently completing or requiring minimal assistance with inspiratory muscle strength training (IMST); Willing to adhere to the IMST protocol (approximately 5-10 minutes per day for 8 weeks); Optional inclusion of inspiratory muscle weakness (MIP <80 cmH₂O for men, <70 cmH₂O for women) will also be assessed.
Exclusion: Recent respiratory therapy or major medication changes; Participants with a pacemaker or other medical implants containing magnets or electronics will be noted and excluded from body composition analyses; tMoCA <18, or diagnosis of neurodegenerative illness at the discretion of principal investigator (except MCI); Current evidence of any major psychiatric disorder including psychosis (at the discretion of principal investigator), bipolar disorder, severe major depression (PHQ-9 > 20); Unstable cardiovascular or pulmonary disease; Self-reported severe untreated or unstable obstructive sleep apnea (OSA); Recent start (within the past month) of CPAP or BiPAP, or recent use of inspiratory muscle training; Lung and eardrum injuries; Non-English speaking.