Lidocaine injected into a brain artery for hard-to-treat migraine and headache
Tests lidocaine injected into brain blood vessels in adults with chronic migraine.
Plain-language title generated from the registry record
Registry title: Localized Injection of Lidocaine Via the Middle Meningeal Artery for Headache Treatment
Key facts
- Where
- Camden, United StatesSee the site
- Phase
- Phase 2
Where in United States
- Cooper University Health CareCamden, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Daniel A Tonetti, MD
- Trial code
- NCT07361549
- Record updated
- 1 October 2026
- Original description
The goal of this clinical trial is to test whether injecting lidocaine into two blood vessels of the brain can help treat chronic headaches (migraines)Read full original descriptionShow less
Localized Injection of Lidocaine Via the Middle Meningeal Artery for Headache Treatment: A Randomized, Double-Blinded, Parallel Phase 2 Clinical Trial
The goal of this clinical trial is to test whether injecting lidocaine into two blood vessels of the brain can help treat chronic headaches (migraines)
Inclusion: Age 18 years or above; Diagnosis of chronic migraine; Referred for diagnostic cerebral angiography to screen for intracranial pathology; Written informed consent able to be obtained from subject.
Exclusion: Concomitant intracranial pathology (eg, intracranial malignancy); Taking chronic medications that, when co-administered with lidocaine and other local anesthetics, are at increased risk of developing methemoglobinemia (nitrates/nitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials, anticonvulsants, acetaminophen, metoclopramide, quinine, sulfasalazine); Concurrent participation in another research protocol for investigation of an experimental therapy; Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data; Known hypersensitivity and/or contraindication to lidocaine or local anesthetics of the amide type; Known contraindications for angiography (eg, ESRD not requiring hemodialysis). Patients with contrast allergy with be premeditated with diphenhydramine and steroids; Per DSA imaging, presence of a cerebrovascular pathology known to cause headache (eg, arteriovenous malformation, dural arteriovenous fistula); Baseline HIT-6 score less than 50; Pregnant, breastfeeding, or unwilling to practice contraception during participation in the study; Contraindication to anesthetic agents used for conscious sedation/monitored anesthesia care (MAC); Per DSA imaging, presence of anastomosis or anatomical variation (eg, branches of middle meningeal artery) that could lead to increased procedural risk; Per DSA imaging, lack of endovascular access to either middle meningeal artery, or origin of the middle meningeal artery other than from the external carotid artery; Known or suspected inability to adhere to study protocol or protocol requirements, as per discretion of the Investigator or treating provider.