Two blood pressure drug pairs for high blood pressure after childbirth
Compares nifedipine with enalapril against nifedipine with labetalol in women after giving birth.
Plain-language title generated from the registry record
Registry title: Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension Study
Key facts
- Where
- Cleveland, United StatesSee the site
Where in United States
- Cleveland ClinicCleveland, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- The Cleveland Clinic
- Trial code
- NCT07363343
- Record updated
- 3 August 2026
- Original description
To determine if nifedipine and enalapril will have better blood pressure control in the postpartum setting compared to nifedipine and labetalol.Read full original descriptionShow less
Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension Study (NEPHRON)
To determine if nifedipine and enalapril will have better blood pressure control in the postpartum setting compared to nifedipine and labetalol.
Inclusion: Postpartum women aged 18 years or older; Clinical diagnosis of hypertensive disorder in pregnancy (gestational hypertension, chronic hypertension, preeclampsia with or without severe features); Taking Nifedipine 60 mg every 12 hours for blood pressure control; Persistently elevated blood pressure at/above 140/90 mmHg in a 24-hour time period or have one or more severe range blood pressure at/above 160/110 mmHg requiring a second antihypertensive medication; English speaking.
Exclusion: Heart block; Heart rate <60 or >120 beats per minute; Heart failure; Active connective tissue disease; Creatinine >1.5 mg/dL; Taking ≥2 antihypertensive agents during pregnancy; Renal artery stenosis; Cerebrovascular accident; Failed treatment or contraindications to nifedipine, enalapril or labetalol.