Mindfulness Practice Added to Accelerated Brain Stimulation for Depression
Tests daily guided mindfulness practice alongside brain stimulation in adults with depression.
Plain-language title generated from the registry record
Registry title: Mindfulness Training During Accelerated TMS for Depression
Key facts
- Where
- Charleston, United StatesSee the 2 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT07369557, who can take part
Where in United States
- IOPCharleston, United StatesTaking people
- Medical University of South Carolina (MUSC), Brain Stimulation Laboratory Institute of PsychiatryCharleston, United StatesNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Medical University of South Carolina
- Trial code
- NCT07369557
- Record updated
- 6 October 2026
- Original description
This NIH-funded single-arm pilot tests the feasibility, acceptability, and preliminary effects of embedding brief guided mindfulness practice (via the Waking Up smartphone app) into the inter-session intervals of clinically administered accelerated intermittent theta-burst stimulation (aiTBS) for major depressive disorder (MDD). Participants receive aiTBS as standard clinical care at MUSC; the research intervention is daily guided mindfulness practice during the aiTBS course. Outcomes include feasibility/acceptability, changes in state mindfulness and hedonic tone (Day 0 to Day 5), perceived ease of meditation, trait mindfulness at 4 and 12 weeks, and durability of antidepressant response (PHQ-9) at 4 and 12 weeks.Read full original descriptionShow less
MB-TBS: Mindfulness-Based Theta-Burst Stimulation-A Pilot Study Integrating Mindfulness Training Into Accelerated Neuromodulation Therapy for Depression
This NIH-funded single-arm pilot tests the feasibility, acceptability, and preliminary effects of embedding brief guided mindfulness practice (via the Waking Up smartphone app) into the inter-session intervals of clinically administered accelerated intermittent theta-burst stimulation (aiTBS) for major depressive disorder (MDD). Participants receive aiTBS as standard clinical care at MUSC; the research intervention is daily guided mindfulness practice during the aiTBS course. Outcomes include feasibility/acceptability, changes in state mindfulness and hedonic tone (Day 0 to Day 5), perceived ease of meditation, trait mindfulness at 4 and 12 weeks, and durability of antidepressant response (PHQ-9) at 4 and 12 weeks.
Inclusion: Clinical diagnosis of MDD and eligible for aiTBS at MUSC; Already enrolled in aiTBS course at MUSC; English proficiency; Smartphone or willingness to use study-provided device.
Exclusion: Concurrent neuromodulation (ECT, VNS); TMS contraindications (e.g., seizure history, implants, pregnancy); Psychotic disorder, bipolar disorder, active substance use disorder, high suicide risk; Unable/unwilling to engage in mindfulness or complete questionnaires.