Left bundle branch pacing in hypertrophic cardiomyopathy after heart muscle surgery
Compares two defibrillator types in adults with hypertrophic cardiomyopathy after myectomy surgery.
Plain-language title generated from the registry record
Registry title: Left Bundle Branch Pacing in Patients With Hypertrophic Cardiomyopathy After Myectomy
Key facts
- Where
- Novosibirsk, RussiaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Source: NCT07372196, who can take part
Where in Russia
- Meshalkin Scientific Research Center of the Ministry of Health of RussiaNovosibirsk, RussiaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Meshalkin Research Institute of Pathology of Circulation
- Trial code
- NCT07372196
- Record updated
- 28 January 2026
- Original description
Pilot interventional randomized clinical trial to study the efficacy of left bundle branch pacing in patients with hypertrophic cardiomyopathy after myectomy for the prevention of progression of heart failure, prevent the occurrence of life-threatening rhythm disturbances and promote reverse remodeling of the LV.Read full original descriptionShow less
Left Bundle Branch Pacing in Patients With Hypertrophic Cardiomyopathy After Myectomy
Pilot interventional randomized clinical trial to study the efficacy of left bundle branch pacing in patients with hypertrophic cardiomyopathy after myectomy for the prevention of progression of heart failure, prevent the occurrence of life-threatening rhythm disturbances and promote reverse remodeling of the LV.
The aim of the study is to evaluate the comparative efficacy and safety of implantation of a cardioverter-defibrillator with left bundle branch block pacing and a dual-chamber cardioverter-defibrillator in patients with HCM and complete left bundle branch block after myectomy at high risk of SCD.
Objectives of the study:
1. To analyze the safety of ICD implantation procedures with LBBB pacing in patients with HCM and LBBB after myectomy at high risk of SCD; 2. To develop a technique for LBBB lead implantation in patients with HCM and LBBB after myectomy; 3. To conduct a comparative analysis of QRS complex duration data based on ECG data before and after surgery, LV activation time, and pacing threshold based on postoperative programming data; 4. To conduct a comparative analysis of the functional class of CHF, NT-proBNP, the presence/absence of interventricular and intraventricular dyssynchrony, the degree of diastolic dysfunction, LVEF, and LV EDV based on echocardiography data before and 12 months after surgery; 5. Conduct a comparative analysis of QRS complex duration data based on ECG data, LV activation time, pacing threshold, the presence of recorded episodes of AF, VT, VF, antitachycardia and shock therapy according to programming data at 3, 6, and 12 months after surgery; 6. Assess quality of life before and 12 months after surgery using the KCCQ-12 questionnaire; 30 patients (15 patients in each group) will be randomly separated into 2 groups. All participants go through ICD programming at 3, 6, and 12 months after myectomy, assessment of left ventricular remodeling based on ECG and echocardiography, NT-proBNP, assessment of quality of life before surgery and 12 months after surgery.
Inclusion: Men and women aged 18 years and older; Patients with post-myectomy HCM who develop LBBB with a QRS complex greater than 130 ms and a high risk of SCD (HCM Risk-SCD ≥ 6%); Signed informed consent to participate in the study.
Exclusion: History of AMI less than three months prior to study inclusion; Heart transplantation or implantation of an LVAD is planned within the next 6 months; Acute renal and hepatic failure; Acute infectious diseases; Presence of mental illness; Presence of other illnesses for which life expectancy is less than one year; Absence of QRS complex morphology consistent with LBBB in LBBB with a positive QRS complex less than 130 ms; Presence of baseline complete RBBB; Patients with intermediate or low risk of SCD; Patient refusal to participate in the study at any stage.