Electrical stimulation of a head artery for migraine that is hard to treat
Tests whether stimulating an artery with electricity is safe in adults with migraine.
Plain-language title generated from the registry record
Registry title: Stimulation of External Carotid Artery Circulation
Key facts
- Where
- Galveston, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 100 years old?
Source: NCT07402954, who can take part
Where in United States
- University of Texas Medical BranchGalveston, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- The University of Texas Medical Branch, Galveston
- Trial code
- NCT07402954
- Record updated
- 20 February 2026
- Original description
This study is testing a new approach to help people with migraine headaches. Researchers want to find out if using electrical stimulation to affect blood flow in the external carotid artery is safe and practical for helping control headaches.Read full original descriptionShow less
Feasibility and Safety of Endovascular Bipolar Stimulation of the Middle Meningeal Artery for Refractory Headaches (MMA-Stim)
This study is testing a new approach to help people with migraine headaches. Researchers want to find out if using electrical stimulation to affect blood flow in the external carotid artery is safe and practical for helping control headaches.
The goal of the study is to determine whether this approach could improve headache symptoms and overall outcomes for people with migraines.
Inclusion: Age ≥18; Chronic migraine or status migrainosus, or craniofacial pain refractory to maximal medical therapy who are undergoing MMA IA lidocaine infusion; Subject has provided informed consent.
Exclusion: Previous MMA intervention or craniotomy that could result in MMA occlusion; Any implanted electronic device (pacemaker, ICD, DBS, VNS, cochlear implant, spinal cord stimulator); Known allergies to lidocaine; Seizure disorder, history of seizures, or increased seizure susceptibility; Hemodynamic instability, any condition where brief hemodynamic shifts may pose risk; Significant cardiovascular disease (unstable angina, severe arrhythmias, recent MI); Active systemic infection; Vulnerable populations (i.e. pregnant individuals, children, prisoners, individuals lacking decision-making capacity, persons with cognitive impairment, those unable to provide informed consent); Intracranial vascular malformations or dural AVF; Severe autonomic dysfunction.