Different doses of NNC0662-0419 for lowering blood sugar in type 2 diabetes
Tests NNC0662-0419 against semaglutide or placebo in adults with type 2 diabetes.
Plain-language title generated from the registry record
Registry title: A Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 Diabetes
Key facts
- Where
- Blackfoot, Boston, Chicago, Dallas, Dayton, Greensboro, Hollywood, Houston, Kingwood, Lancaster, Lomita, Long Beach, Los Alamitos, Memphis, Miami, Miramar, Ocoee, San Diego, Shavano Park, Springfield, Statesville, Walnut Creek, and Weston, United StatesSee the 23 sites
- Phase
- Phase 2
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Source: NCT07415954, who can take part
Where in United States
- Elite Clinical TrialsBlackfoot, United StatesTaking people
- Brigham & Women's HospitalBoston, United StatesNot yet recruiting
- Cedar Crosse Research CenterChicago, United StatesTaking people
- University of Texas Southwestern Medical CenterDallas, United StatesTaking people
- Providence Center for Clinical ResearchDayton, United StatesTaking people
- PharmQuestGreensboro, United StatesTaking people
- Encore Medical Research LLCHollywood, United StatesTaking people
- JCCT- Juno NW HoustonHouston, United StatesTaking people
- Frontier Clinical Research - KingwoodKingwood, United StatesNot yet recruiting
- First Valley Medical GroupLancaster, United StatesTaking people
- Torrance Clinical Research Institute, Inc.Lomita, United StatesTaking people
- Ark Clinical ResearchLong Beach, United StatesTaking people
- Pacific Clinical StudiesLos Alamitos, United StatesTaking people
- CNS HealthcareMemphis, United StatesTaking people
- Bioclinical Research AllianceMiami, United StatesTaking people
- South Broward Research LLCMiramar, United StatesTaking people
- West Orange EndocrinologyOcoee, United StatesNot yet recruiting
- Wetlin Research Associates, Inc.San Diego, United StatesTaking people
- Consano Clinical Research, LLCShavano Park, United StatesTaking people
- Headlands ResearchSpringfield, United StatesTaking people
- Piedmont Healthcare StatesvilleStatesville, United StatesTaking people
- Diablo Clinical Research, Inc.Walnut Creek, United StatesTaking people
- Encore Medical Research of WestonWeston, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Novo Nordisk A/S
- Trial code
- NCT07415954EU 2025-523260-20-00
- Record updated
- 11 September 2026
- Original description
This study is being done to look at the effect and safety of different doses of NNC0662-0419 in people living with type 2 diabetes when compared to placebo or semaglutide. The purpose of this clinical study is to find out if NNC0662-0419 is effective and safe for treating people living with type 2 diabetes. Participants will get either NNC0662-0419, semaglutide or placebo. Which treatment participants get is decided by chance. NNC0662-0419 is a new medicine which cannot be prescribed by doctors but has previously been tested in humans. Semaglutide is an approved medication to treat type 2 diabetes.Read full original descriptionShow less
Efficacy and Safety of Once-weekly Subcutaneous NNC0662-0419 in Participants With Type 2 Diabetes - a Dose-finding Study
This study is being done to look at the effect and safety of different doses of NNC0662-0419 in people living with type 2 diabetes when compared to placebo or semaglutide. The purpose of this clinical study is to find out if NNC0662-0419 is effective and safe for treating people living with type 2 diabetes. Participants will get either NNC0662-0419, semaglutide or placebo. Which treatment participants get is decided by chance. NNC0662-0419 is a new medicine which cannot be prescribed by doctors but has previously been tested in humans. Semaglutide is an approved medication to treat type 2 diabetes.
Inclusion: Male or female (sex at birth); Age 18-75 years (both inclusive) at the time of signing the informed consent; Glycated haemoglobin (HbA1c) of 7.0-10.0 percent (%) (53-86 millimoles per mole [mmol/mol]) (both inclusive) as assessed by central laboratory at screening; Willingness to obtain a high weight loss (greater than [>] 25% of weight at baseline).
Exclusion: Treatment with any medication for the indication of diabetes or obesity other than stated in the inclusion criteria within 90 days before screening. However, short term insulin treatment for a maximum of 14 consecutive days and prior insulin treatment for gestational diabetes are allowed; Uncontrolled and potentially unstable diabetic retinopathy or maculopathy. Pharmacological pupil-dilation is a requirement unless using a digital fundus photography camera specified for non-dilated examination; Known hypoglycaemic unawareness as indicated by the investigator according to Clarke's Questionnaire.