Knee Osteoarthritis Rehabilitation Through Rotational Inertia
Key facts
- Who runs it
- University of Colorado, Denver
- Where
- Aurora, United StatesSee the site
- Trial code
- Status
- Recruiting
- People taking part
- 60 people, planned
- Started
- 20 Aug 2025
- Expected to end
- 31 May 2029
- Type of study
- Interventional, 2 groups
- Treatments tested
- Eccentric resistance training
- Record updated
- 20 February 2026
Who can take part
- Age
- 40 years to 70 years
- Sex
- Women and men
- Healthy volunteers
- Can take part
The registry criteria, word for word
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Who can take part
- Aged 40-70 years
- Radiographically confirmed knee OA (Kellgren-Lawrence [KL] Grade 2 or 3)
- Able to walk independently (assistive devices permitted)
- Aged 40-70 years
- No radiographic evidence of knee OA (KL Grade 0 or 1)
- No frequent knee pain
- No history of:
- Knee surgery (e.g., ACL reconstruction, meniscectomy, patellar realignment)
- Significant knee injury (e.g., ligament tears, fractures, dislocations)
- Diagnosed knee conditions (e.g., patellofemoral pain syndrome, bursitis)
Who cannot take part
- Uncontrolled hypertension or other cardiovascular disease
- A musculoskeletal condition preventing physical testing
- Neurological muscle weakness (e.g., stroke, spinal cord injury)
- BMI >34.9 kg/m²
- Recent hospitalization (past 3 months)
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 70 years old?
Where in United States
- University of Colorado DenverAurora, United StatesContact: Katie BoncellaTaking people
About the trial
What the trial wants to find out
This study is testing whether a new type of exercise program, called eccentric overload training using a flywheel device, can improve stair-climbing ability in people with knee osteoarthritis. The flywheel device provides resistance throughout the entire movement and gives extra challenge during the muscle-lengthening phase of exercise. This type of training may improve muscle structure, strength, and coordination more effectively than conventional methods.
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The study's central idea is that better muscle quality and improved coordination will lead to smoother, safer stair movement and reduce the risk of falls. Advanced tools such as ultrasound imaging and motion analysis will be used to measure muscle health and movement patterns in detail.
The hypothesis is that individuals with knee osteoarthritis have poorer muscle quality and less coordinated stair-stepping compared to healthy adults, and that performing eccentric overload training will enhance muscle quality, improve movement coordination, and make stair navigation safer and more efficient.
The 2 groups in the trial
- Initial-Exercise'Treatment being tested
The initial exercise group will participate in an 8-week eccentric overload exercise intervention using a kBox, with two sessions per week. Participants will then cease the intervention for 8 weeks to enter a detraining period.
Treatment: Eccentric resistance training
- Delayed-ExerciseTreatment being tested
The 'Delayed-Exercise' group will maintain their normal activity, without intervention, for the first 8 weeks of the study. In the second half of the study, they will begin the same 8-week kBox training completed by the 'Initial-Exercise' group.
Treatment: Eccentric resistance training
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Exploring the Benefits of Eccentric Training for Aging Adults With Knee Osteoarthritis
- Fit questions
- Built from NCT07424352, who can take part
- Record updated
- 20 February 2026