Home Video-Game Exercises for Arm and Hand Use in Multiple Sclerosis
Compares home video-game arm exercises with usual home physiotherapy in adults with multiple sclerosis.
Plain-language title generated from the registry record
Registry title: Home-Based Exergame Rehabilitation for Upper Limb Function in People With Multiple Sclerosis
Key facts
- Where
- Villaviciosa de Odón, SpainSee the site
Where in Spain
- Universidad Europea de MadridVillaviciosa de Odón, SpainNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Marina Castel Sánchez
- Trial code
- NCT07430462
- Record updated
- 24 February 2026
- Original description
This randomized pilot clinical trial aims to evaluate the effectiveness, feasibility, and cost-effectiveness of a semi-autonomous upper-limb rehabilitation program based on therapeutic exergames in people with Multiple Sclerosis (MS). The intervention integrates intensive motor practice, multisensory feedback, and cognitively demanding tasks to enhance upper-limb function, dexterity, and patient autonomy. Participants will be randomly assigned to either an exergame-based home rehabilitation program with remote physiotherapist supervision or a dose-matched conventional home-based physiotherapy program.Read full original descriptionShow less
Effectiveness and Feasibility of a Home-Based Exergame Rehabilitation Protocol for Upper Limb Function in Individuals With Multiple Sclerosis: A Randomized Controlled Pilot Trial
This randomized pilot clinical trial aims to evaluate the effectiveness, feasibility, and cost-effectiveness of a semi-autonomous upper-limb rehabilitation program based on therapeutic exergames in people with Multiple Sclerosis (MS). The intervention integrates intensive motor practice, multisensory feedback, and cognitively demanding tasks to enhance upper-limb function, dexterity, and patient autonomy. Participants will be randomly assigned to either an exergame-based home rehabilitation program with remote physiotherapist supervision or a dose-matched conventional home-based physiotherapy program.
The primary outcome is upper-limb functionality measured by the Action Research Arm Test (ARAT). Secondary outcomes include motor function, manual ability, quality of life, usability, adherence, and digital performance metrics related to the execution of motor and cognitive tasks. Follow-up at 16 weeks will assess the sustainability of treatment effects.
This study seeks to generate evidence on whether exergame-based rehabilitation can serve as an accessible, scalable, and patient-centered alternative to conventional home-based upper-limb rehabilitation for individuals with MS.
Inclusion: Age ≥ 18 years; Clinical diagnosis of Multiple Sclerosis with EDSS score between 2.0 and 6.5, with upper-limb involvement; Ability to maintain independent sitting and to stand with or without assistive devices; Upper-limb functional capacity between 11 and 54 points on the ARAT, indicating limited to substantial impairment; Cognitive ability to understand and follow simple instructions, demonstrated by a Mini-Mental State Examination score ≥ 23; Provision of written informed consent by the participant or legally authorized representative.
Exclusion: Botulinum toxin treatment in the upper limb within the previous 6 months; Acute illness, musculoskeletal injury, or pain interfering with the ability to perform the intervention exercises; Disruptive behavior or other conditions that significantly hinder participation in the rehabilitation program; Active epilepsy or any medical contraindication to physical exercise; Uncompensated visual or hearing impairments that limit participation.