How genes and diet affect body weight and brain inflammation in obesity
Studies how genes and diet relate to obesity and brain inflammation in adults.
Plain-language title generated from the registry record
Registry title: Inherited and Environmental Risks Acting on Body Weight
Key facts
- Where
- Seattle, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 20 and 45 years old?
Source: NCT07430852, who can take part
Where in United States
- University of WashingtonSeattle, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Washington
- Trial code
- NCT07430852
- Record updated
- 2 October 2026
- Original description
The goal of this research is to investigate genetic and environmental factors that contribute to obesity through brain inflammation. The main questions are 1) if identical twins, who differ in food consumption habits, have differences in adiposity markers and brain inflammation and 2) if signs of brain inflammation in response to a specific diet is modified by genetics.Read full original descriptionShow less
Genetic and Environmental Contributions to Obesity Pathogenesis
The goal of this research is to investigate genetic and environmental factors that contribute to obesity through brain inflammation. The main questions are 1) if identical twins, who differ in food consumption habits, have differences in adiposity markers and brain inflammation and 2) if signs of brain inflammation in response to a specific diet is modified by genetics.
Inclusion: Age 20-45 years; Differs in habitual diet from co-twin (study 1); Willing to undergo 7-day overfeeding and hypocaloric feeding periods (study 2); Member of the Washington State Twin Registry.
Exclusion: Current use of weight-loss medications or other medications known to alter appetite (e.g., atypical anti-psychotics); History of bariatric surgery or active participation in weight-loss program; Major medical or neurological disorder (e.g., diabetes, multiple sclerosis); Individuals with severe food allergies and dietary restrictions (e.g., vegan/vegetarian, gluten-free, others) (study 2); Lifetime eating disorder; Known gallbladder disease, anemia, impaired thyroid, kidney or liver function or hypertriglyceridemia (>350 mg/dl) (study 2); High levels of vigorous physical activity (>300 min./week); Pregnancy, menopause, or breastfeeding; Co-twin unwilling or unable to participate; MRI contraindication (e.g., implanted metal, claustrophobia); Current smoking or heavy alcohol use (≥ 2 drinks per day for females and ≥ 3 drinks per day for males); BMI > 45 kg/m2 (study 1); BMI > 35 kg/m2 (study 2); Weight > 350 pounds or determined to be safe by MRI tech (MRI limit); Inability to participate in a controlled diet program (study 2) or undergo other study procedures; Non-English speaking-or-reading individuals.